The impact of cholecalciferol supplementation on the systemic inflammatory profile: a systematic review and meta-analysis of high-quality randomized controlled trials.
Eur J Clin Nutr. 2017 May 10. doi: 10.1038/ejcn.2017.67. [Epub ahead of print]
- Anti-inflamatory cytokines increased when vitamin D levels were raised above 30 ng – RCT Very similar to meta-analysis on this page
- Inflammation reduced by a single dose of Vitamin D (200,000 IU) – RCT Jan 2016
- Inflammatory diseases: review of vitamin D, with many tables – May 2014
- 4000 IU vitamin D daily for just 5 days reduced inflammation after heart attack – RCT Jan 2013
- Urinary Tract Infection in infants 5.6 X MORE likely if low Vitamin D, 3.3 X LESS likely if supplement – July 2016
- Inflammatory blood markers (CRP, white blood cells) vary with Vitamin D level– Jan 2017
- Eczema (Atopic Dermatitis) treated by 1,600 IU Vitamin D (again) – Meta-analysis Aug 2019
- Septic children have low Vitamin D (54 studies, ignored Vitamin D Receptor) – meta-analysis April 2019
- Diabetic inflammation reduced by Vitamin D – meta-analysis Feb 2018
- 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017
- Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017
- Inflammation reduced when vitamin D supplementation raised level higher than 32 ng – meta-analysis May 2017
- Eczema (Atopic Dermatitis) treated by 1600 IU of vitamin D – meta-analysis Dec 2016
- Chronic pancreatitis associated with somewhat lower levels of vitamin D – meta-analysis July 2016
- Chronic Pancreatitis associated with painful bones (vitamin D) – meta-analysis July 2013
- Vitamin D and Respiratory Tract Infections – meta-analysis with charts June 2013
- Vitamin D reduces respiratory tract infections by 40 percent– meta-analysis Dec 2012
Calton EK1, Keane KN2, Newsholme P2, Zhao Y3, Soares MJ1.
1 Food, Nutrition & Health, School of Public Health, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia.
2 School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia.
3 Occupation and the Environment, School of Public Health, Curtin University, Perth, WA, Australia.
Causal links between vitamin D status [25(OH)D] and systemic inflammation were examined through a systematic review of randomized controlled trials (RCTs). Selected RCTs were ⩾12 weeks, conducted in adults free of acute inflammatory disease, and of high-quality (Jadad score ⩾3). Of 14 studies that met our criteria, 9 studies (15 study arms) permitted extraction of data. There was no effect on the weighted mean difference (WMD) of IL-6 (WMD (95% confidence interval)=0.1, (-0.166, 0.366) pg/ml, P=0.462) or C-reactive protein (CRP) (WMD=-0.324, (-1.007, 0.359) mg/l, P=0.352).
Subgroup analyses of trials achieving ⩾80 nmol/l indicated a trend for lower CRP (WMD=-0.834, (-1.726, 0.058) mg/l, P=0.067), however heterogeneity was significant (I2=66.7%, P=0.017). Studies employing a low dose (<1000 IU/d) showed increased CRP (WMD=0.615, (0.132, 1.098), P=0.013). In contrast, ⩾1000 IU/d had a favourable effect on CRP (WMD=-0.939, (-1.805, -0.073), P=0.034) but heterogeneity was significant (I2=61.3%, P=0.017). Meta-regression indicated that older age predicted a significant decrease in IL-6 (β=-0.02, (-0.034, -0.006) pg/ml, P=0.013) and CRP (β=-0.06, (-0.103, -0.017), P=0.01), whereas a greater percentage of females (β=0.027, (0.011, 0.044), P=0.004) and longer study duration independently predicted a higher WMD for CRP (β=0.049, (0.018, 0.079), P=0.005). Available high-quality RCTs did not support a beneficial effect of cholecalciferol on systemic IL-6 and CRP. Future studies should consider the confounding effects of age, gender and study duration, while possibly targeting an achieved 25(OH)D ⩾80 nmol/l.
PMID: 28488684 DOI: 10.1038/ejcn.2017.67
|1052 visitors, last modified 11 May, 2017, URL: