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Inflammation markers reduced by Vitamin D - umbrella meta-analysis Oct 2022


Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis

Pharmacol Res . 2022 Oct 4;106484. doi: 10.1016/j.phrs.2022.106484
Elham Moslemi 1 , Vali Musazadeh 2 , Zeynab Kavyani 1 , Navid Naghsh 3 , Seyyed Morteza Seyyed Shoura 1 , Parvin Dehghan 4

Background: Vitamin D supplementation has attracted a lot of attention as a potential modulator of inflammation and oxidative stress, while some studies have reported controversial findings. In this regard, the purpose of this study was to summarize existing systematic reviews and meta-analyses of clinical trials that determined the effects of supplementation with vitamin D on inflammatory and oxidative biomarkers.

Methods: The following international databases were systematically searched till March 20th, 2022: PubMed, Scopus, Embase, Web of Science, and Google Scholar. A random-effects model was applied to evaluate the effects of vitamin D on inflammatory and oxidative stress biomarkers.

Results: Overall, 23 meta-analyses were qualified in this umbrella meta-analysis. Our findings revealed that the vitamin D supplementation significantly reduced

  • serum C-reactive protein (CRP) (ES = -0.42; 95% CI: -0.55, -0.29, p <0.001),
  • tumor necrosis factor-α (TNF-α) (ES = -0.27; 95% CI: -0.42, -0.12; p<0.001), and
  • malondialdehyde (MDA) concentrations (ES = -0.37; 95% CI: -0.48, -0.25, p <0.001).

However, no significant changes were illustrated regarding

  • interleukin-6 (IL-6) (ES = -0.35, 95% CI: -0.80, 0.10; p = 0.125),
  • total antioxidant capacity (TAC) (ES = 0.68; 95% CI: -0.31, 1.66, p = 0.179), and
  • glutathione (GSH) activity (ES = 0.08; 95% CI: -0.44, 0.60, p = 0.757).

Conclusion: The present umbrella meta-analysis indicated that supplementation of vitamin D in adults can improve CRP, TNF-α, and MDA levels under various health conditions. Vitamin D could be considered an adjuvant therapy for relieving inflammation and oxidative stress.


Inflammation Meta-analyses


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