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Diabetes, immune system and Vitamin D – book chapter – 2019

Vitamin D in immune regulation

and diabetes mellitus – Chapter 22
Ihor Shymanskyi, Olha Lisakovska, Dmytro Labudzinskyi, Anna Mazanova and Mykola Veliky
Department of Biochemistry of Vitamins and Coenzymes, Palladin Institute of Biochemistry of National
Academy of Sciences of Ukraine, Kyiv, Ukraine

22.1 Introduction 428
22.2 Vitamin D synthesis and activation 428
22.3 Role of vitamin D in immune regulation and inflammatory responses 432
22.3.1 Vitamin D and innate immunity 432
22.3.2 Vitamin D and adaptive immunity 433
22.3.3 Cytokines in regulation of vitamin D-metabolizing enzymes 434
22.4 Vitamin D and diabetes mellitus 435
22.4.1 Vitamin D modulates β-cell function 435
22.4.2 Vitamin Dauto/paracrine system in diabetes mellitus 437
22.4.3 Antiinflammatory effect of vitamin D in diabetes mellitus 438
22.5 Conclusions 442
References (at bottom of VitaminDWiki page) 443
VitaminDWiki

Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 459 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
    • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

  • Dark Skin 22;   Intervention 49;   Meta-analysis 29;   Obesity 26;  Pregnancy 39;   T1 (child) 36;  Omega-3 10;  Vitamin D Receptor 19;  Genetics 10;  Magnesium 18    Click here to see details

Diabetic Epidemic

  • Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
    Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
    That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
    Chart from the web (2018?)
    Image

Immunity category starts with

190 items in Immunity category

    see also

Virus category listing has 407 items along with related searches

Overview Influenza and vitamin D
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
Search VitaminDWik for INFECTION in title 50 items as of Aug 2019
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Vitamin D Every Day to Keep the Infection Away 2015 file
shows increasing publications on vitamin D and Infection
Image

 Download the PDF from Sci-Hub via VitaminDWiki

Diabetes increases the expression (2) of CPY24A1
which destroys Vitamin D after it is seen by Vit D blood test
Thus preventing Vitamin D from benefiting tissues
(3) Addition of Vitamin D decreases the CYP24A1 expression

Image

Image

Autocrine & Paracrine Systems VDW11475


References

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  • Alfonso, B., Liao, E., Busta, A., Poretsky, L., 2009. Vitamin D in diabetes mellitus—a new field of knowledge poised for D-velopment. Diabetes Metabol. Res. Rev. 25, 417—419.
  • Ali, T., El Esawy, B., Elaskary, A., 2018. Effect of paricalcitol on pancreatic oxidative stress, inflammatory markers, and glycemic status in diabetic rats. Ir. J. Med. Sci. 187, 75—84.
  • Barragan, M., Good, M., Kolls, J., 2015. Regulation of dendritic cell function by vitamin D. Nutrients 7, 8127—8151.
  • Barrat, F., Cua, D., Boonstra, A., Richards, D., Crain, C., Savelkoul, H., et al., 2002. In vitro generation of interleukin 10-producing regulatory CD4 1 T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J.Exp. Med. 195, 603—616.
  • Bhalla, A.K., Paavonen, T., Williams, M., Delves, P., Lydyard, P., 1991. Regulation of interleukin-1 and tumour necrosis factor gene expression in myelomonocytic cell lines by 1,25-dihydroxyvitamin D3. Immunology 72, 61 — 64.
  • Bikle, D., 2014. Vitamin D metabolism, mechanism of action, and clinical applications. Chem. Biol. 21, 319—329.
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  • Brosbol-Ravnborg, A., Bundgaard, B., Hollsberg, P., 2013. Synergy between vitamin D3 and Toll-like receptor agonists regulates human dendritic cell response during maturation. Clin. Dev. Immunol. 2013, 807971.
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  • Jeffery, L., Burke, F., Mura, M., Zheng, Y., Qureshi, O., Hewison, M., et al., 2009. 1,25- Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J. Immunol. 183, 5458—5467.
  • Kagi, L., Bettoni, C., Pastor-Arroyo, E., Schnitzbauer, U., Hernando, N., Wagner, C., 2018. Regulation of vitamin D metabolizing enzymes in murine renal and extrarenal tissues by dietary phosphate, FGF23, and 1,25(OH)2D3. PLoS One 13, e0195427.
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  • Kjalarsdottir, L., Tersey, S., Vishwanath, M., Chuang, J., Posner, B., Mirmira, R., et al., 2018. 1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor. J. Steroid Biochem. Mol. Biol. 185, 17—26 (ahead of print).
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Created by admin. Last Modification: Thursday December 19, 2019 03:37:16 GMT-0000 by admin. (Version 9)

Attached files

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13186 Diabetic inflammation(I & II) and Vitamin D.jpg admin 19 Dec, 2019 02:29 57.02 Kb 276
13185 CYP24A1 unexpressed by addtion of Vitamin D.jpg admin 19 Dec, 2019 02:21 32.53 Kb 174
13184 Diabetes sci-hub.pdf PDF 2019 admin 19 Dec, 2019 02:21 1.07 Mb 220
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