Diabetes, immune system and Vitamin D – book chapter – 2019

Vitamin D in immune regulation

and diabetes mellitus – Chapter 22
Ihor Shymanskyi, Olha Lisakovska, Dmytro Labudzinskyi, Anna Mazanova and Mykola Veliky
Department of Biochemistry of Vitamins and Coenzymes, Palladin Institute of Biochemistry of National
Academy of Sciences of Ukraine, Kyiv, Ukraine

22.1 Introduction 428
22.2 Vitamin D synthesis and activation 428
22.3 Role of vitamin D in immune regulation and inflammatory responses 432
22.3.1 Vitamin D and innate immunity 432
22.3.2 Vitamin D and adaptive immunity 433
22.3.3 Cytokines in regulation of vitamin D-metabolizing enzymes 434
22.4 Vitamin D and diabetes mellitus 435
22.4.1 Vitamin D modulates β-cell function 435
22.4.2 Vitamin Dauto/paracrine system in diabetes mellitus 437
22.4.3 Antiinflammatory effect of vitamin D in diabetes mellitus 438
22.5 Conclusions 442
References (at bottom of VitaminDWiki page) 443

Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 543 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

Number of articles in both categories of Diabetes and:
'This list is automatically updated''

  • Dark Skin 24;   Intervention 56;   Meta-analysis 38;   Obesity 35;  Pregnancy 44;   T1 (child) 39;  Omega-3 11;  Vitamin D Receptor 24;  Genetics 13;  Magnesium 29    Click here to see details

Some Diabetes studies

50 ng of Vitamin D fights Diabetes

T1 Diabetes


Diabetes, Metabolic Syndrome and Magnesium - many studies
Diabetic Epidemic

  • Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
    Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
    That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
    Chart from the web (2018?)

Immunity category starts with

263 items in Immunity category

    see also

Virus category listing has 1369 items along with related searches

Overview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
228 VitaminDWiki pages contained "infection" in title (June 2024)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021
   Only the brain is more complex, nothing about Vitamin D

18 titles in VitaminDWiki contained INNATE or ADAPTIVE as of Jan 2023
Increasing publications on vitamin D and Infection

48 studies are in both Immunity and Virus categories

 Download the PDF from Sci-Hub via VitaminDWiki

Diabetes increases the expression (2) of CPY24A1
which destroys Vitamin D after it is seen by Vit D blood test
Thus preventing Vitamin D from benefiting tissues
(3) Addition of Vitamin D decreases the CYP24A1 expression



Autocrine & Paracrine Systems VDW11475


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