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"Senior moment" 25X more likely with low vitamin D - Feb 2012

Vitamin D insufficiency and mild cognitive impairment: cross-sectional association

C. Annweiler 1,2,3, ceannweiler at chu-angers.fr, B. Fantino2,3; A. M. Schott4; P. Krolak-Salmon5; G. Allali6; O. Beauchet1,2,3
Article first published online: 16 FEB 2012 European Journal of Neurology © 2012 EFNS
1 Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, France
2 Angers University Memory Center, France
3 UPRES EA 2646, University of Angers, UNAM, Angers, France
4 Hospices Civils de Lyon, Pôle IMER; EA 4129, RECIF, Université de Lyon; INSERM U1033, Lyon, France
5 Memory Center, Lyon University Hospital, INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, University of Lyon, Lyon, France
6 Department of Neurology, Geneva University Hospitals, Switzerland

Background:? Low serum 25-hydroxyvitamin D (25OHD) concentrations have been associated with dementia. The association with mild cognitive impairment (MCI) has not yet been explored. Our aim was to examine the association between vitamin D status and MCI status amongst older community-dwellers with subjective memory complaint.

Methods:? Ninety-five non-demented Caucasian community-dwellers with subjective memory complaint (mean, 71.1 ± 6.4 years; 54.7% women) included in the Gait and Alzheimer Interaction Tracking (GAIT) study were categorized into two groups according to Winblad et al. consensus criteria [i.e., subjects with MCI or cognitively healthy individuals (CHI)].
Serum 25OHD concentration was divided into quartiles, the fourth quartile corresponding to the highest 25OHD concentration.
The cross-sectional associations between 25OHD concentrations and MCI were modeled using logistic regressions.

  • Age,
  • gender,
  • body mass index,
  • number of comorbidities,
  • education level,
  • Mini-Mental State Examination score,
  • Frontal Assessment Battery score,
  • Geriatric Depression Scale score,
  • creatinine clearance, and
  • season tested were considered as potential confounders.

Results:? Compared to CHI, patients with MCI (n = 43; mean, 71.4 ± 5.6 years; 34.9% women) had lower mean serum 25OHD concentrations (P = 0.006) and belonged more often to the lower quartiles compared to the highest quartile (P = 0.03). Increased serum 25OHD concentration was associated with a lower risk of MCI [adjusted odds ratio (OR) = 0.96, P = 0.002].

Accordingly, lower quartiles of 25OHD were positively associated with MCI whilst using the highest quartile as reference (adjusted OR = 25.46, P = 0.002 for the first quartile; adjusted OR = 6.89, P = 0.03 for the second quartile; and adjusted OR = 10.29, P = 0.02 for the third quartile).

Conclusions:? Low 25OHD concentrations were associated with MCI status in older non-demented community-dwellers with subjective memory complaint.

From the author:

The quartiles were designed as follows: first quartile between 10.0 and 40.0nmol/L, second quartile between 41.0 and 59.0nmol/L,
third quartile between 60.0 and 79.0nmol/L, and fourth quartile between 80.0 and 189.0nmol/L.

Converting to units of nanograms:

  • Q1: 4-16 ng/ml
  • Q2: 16-24 ng/ml
  • Q3: 24-32 ng/ml
  • Q4: 32- 76 ng/ml

Thus: those with 4-16 ng vitamin D were 25X more likely to have senior moments than those with 32-76 ng

See also VitaminDWiki