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Pneumonia in seniors was 2.5X more likely if low vitamin D – June 2014

Vitamin D Level and Risk of Community-Acquired Pneumonia and Sepsis

Nutrients 2014, 6(6), 2196-2205; doi:10.3390/nu6062196 (doi registration under processing)
Anna J. Jovanovich 1, Adit A. Ginde 2, John Holmen 3, Kristen Jablonski 1, Rebecca L. Allyn 4, Jessica Kendrick 1,4 and Michel Chonchol 1, Michel.Chonchol at ucdenver.edu
1 Division of Renal Diseases and Hypertension, University of Colorado Denver, Denver, CO 80045 USA
2 Department of Emergency Medicine, University of Colorado Denver, Denver, CO 80045 USA
3 Intermountain Healthcare, Salt Lake City, UT 84157, USA
4 Denver Health Medical Center, Denver, CO 80204, USA

Previous research has reported reduced serum 25-hydroxyvitamin D (25(OH)D) levels is associated with acute infectious illness. The relationship between vitamin D status, measured prior to acute infectious illness, with risk of community-acquired pneumonia (CAP) and sepsis has not been examined. Community-living individuals hospitalized with CAP or sepsis were age-, sex-, race-, and season-matched with controls. ICD-9 codes identified CAP and sepsis; chest radiograph confirmed CAP.

Serum 25(OH)D levels were measured up to 15 months prior to hospitalization.

Regression models adjusted for diabetes, renal disease, and peripheral vascular disease evaluated the association of 25(OH)D levels with CAP or sepsis risk. A total of 132 CAP patients and controls were 60 ± 17 years, 71% female, and 86% Caucasian.
The 25(OH)D levels <37 nmol/L (adjusted odds ratio (OR) 2.57, 95% CI 1.08–6.08) were strongly associated with increased odds of CAP hospitalization.

A total of 422 sepsis patients and controls were 65 ± 14 years, 59% female, and 91% Caucasian. The 25(OH)D levels <37 nmol/L (adjusted OR 1.75, 95% CI 1.11–2.77) were associated with increased odds of sepsis hospitalization. Vitamin D status was inversely associated with risk of CAP and sepsis hospitalization in a community-living adult population. Further clinical trials are needed to evaluate whether vitamin D supplementation can reduce risk of infections, including CAP and sepsis.


PDF is attached at the bottom of this page

See also VitaminDWiki

See also web

  • Community-acquired pneumonia WikiPedia
    CAP = not acquired in hospital
    CAP occurs throughout the world and is a leading cause of illness and death.
    Causes of CAP include bacteria, viruses, fungi, and parasites.
    WHO estimates that one in three newborn infant deaths are due to pneumonia
    elderly individuals are particularly at risk for CAP and associated mortality

Image

Pneumonia review by Vitamin D Council May 2014

Attached files

ID Name Comment Uploaded Size Downloads
4029 Pneu Wikipedia.jpg admin 10 Jun, 2014 15:27 35.40 Kb 495
4028 CAP.pdf PDF 2014 admin 10 Jun, 2014 15:24 200.35 Kb 384
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