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Pneumonia patients 3 X more likely to die if low vitamin D – meta-analysis Sept 2017

Prognostic value of vitamin D in patients with pneumonia: A systematic review and meta-analysis

Tropical Journal of Pharmaceutical Research September 2017; 16 (9): 2267-2273
Yu mei Wang1, Chen ling Tang2, Ming Che2*, Xiu qin Wang2 and Ai chun Li2
1 Management Office of Hospital Infection,
2 Department of Tuberculosis Internal Medicine, The Chest Hospital of Linyi, Linyi City, Shandong Province, 276034, China
For correspondence: Email: go0654 at 163.com

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Purpose: To investigate the prognostic role of vitamin D in pneumonia patients through meta-analysis.

Methods: PubMed and Embase were systematically searched for relevant studies that assessed the impact of vitamin D on the risk of adverse outcomes among patients with pneumonia. Risk ratios (RR) with 95 % confidence intervals (95 % CI) were pooled using meta-analysis. Q-test and I2 statistics were used to evaluate between-study heterogeneity.

Results: Six studies were finally included in the meta-analysis. The results of meta-analysis of these studies indicated that low vitamin D status was associated with higher risk of mortality among pneumonia patients (RR = 2.59, 95 % CI = 1.32-5.08; p = 0.005). Results from meta-analysis of studies with adjusted estimates suggest that low vitamin D status was independently associated with higher risk of mortality among pneumonia patients (RR = 3.15, 95 % CI 1.54-6.44, p = 0.002). There was no significant risk of bias in the meta-analysis.

Conclusion: This study demonstrates that low vitamin D level is associated with a higher risk of adverse outcomes in patients with pneumonia.

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