- No effect of season of birth on risk of type 1 diabetes, cancer, schizophrenia and ischemic heart disease, while some variations may be seen for pneumonia and multiple sclerosis
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11 of the MS and Pregnancy studies in VitaminDWiki - There have been
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No effect of season of birth on risk of type 1 diabetes, cancer, schizophrenia and ischemic heart disease, while some variations may be seen for pneumonia and multiple sclerosis
Dermato Endocrinology: Volume 5, Issue 2 April/May/June 2013
Susanna við Streym, Lars Rejnmark, Leif Mosekilde and Peter VestergaardBackground: The risk of type 1 diabetes (T1DM), infections, cancer, schizophrenia and multiple sclerosis (MS) has been associated with environmental factors including vitamin D status.
Materials and Methods: Data were obtained from all children born in Denmark in 1940 (n = 72,839), 1977 (n = 89,570), and 1996 (n = 74,015). Information on contacts to hospitals (1977–2009) was obtained from the National Hospital Discharge Register. The main exposure variable was season of birth as a proxy variable for vitamin D status (summer: April–September and winter: October–March).
Results: No associations between season of birth and risk of MS were seen in the 1940 cohort or the 1996 cohort. In the 1977 cohort, there was a borderline statistically significant decreased risk of MS in those born during wintertime compared with those born during summertime (HR = 0.70, 95% CI: 0.47–1.04, p = 0.07). There were no significant differences within the groups regarding season and risk of T1DM at any age, T1DM before 10 y, infection, any type of cancer, schizophrenia and myocardial infarction.
In the 1977 cohort the risk of pneumonia was significantly lower among those born in the summer compared with the winter at any age (HR 0.91, 95% CI 0.85–0.97, p < 0.01) and at age < 10 y (HR 0.90, 95% CI 0.84–0.97, p < 0.01).
Conclusion: MS and pneumonia in young subjects may be related to season of birth and thus maternal vitamin D exposure. Low sunlight exposure in the winter time leading to low vitamin D levels during pregnancy may be a potential explanation.
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VitaminDWiki – Season of Birth category contains:
Season of birth is a good proxy for Vitamin D (for people far from the Equator)
Statistisically significant, but rarely greater than 20% change
Some health problems need Vitamin D in 2 or 3 trimesters, so are not associated with season
Perhaps some people in born in poor season will need more vitamin D all of their lives
Some Season of Birth studies- Season of birth associated with many health problem (UK Biobank) – Nov 2020
- Preterm birth varies with season: 25 percent more likely if conception in autumn – Feb 2022
- Little sun in first trimester, 2.9 X more likely to have learning disabilities – June 2019
- UV at time of conception associated with Vitamin D Receptor activation 65 years later – Sept 2017
- Autoimmune Addison's Disease – increased risk if born in Dec or Jan – Nov 2016
- Schizophrenia increased 40 percent for Spring births after Danes stopped vitamin D fortification – April 2014
- Season of birth associated with Pneumonia (10 %) and Multiple Sclerosis (30 %) – May 2013
- Majority of Season of Birth health problems should vanish if take Vitamin D
100K monthly, or 50K bi-weekly, or 4K daily
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11 of the MS and Pregnancy studies in VitaminDWiki - Multiple Sclerosis 40 percent more likely if mother had low vitamin D – meta-analysis Jan 2020
- High-dose Vitamin D for Multiple Sclerosis is OK while pregnant – Sept 2019
- Extended breastfeeding cut in half the risk of Multiple Sclerosis – July 2017
- Multiple Sclerosis risk reduced 30 percent by each additional 10 ng of vitamin D at birth (1500 Danes) – Jan 2017
- A gestational dose of vitamin D per day keeps the MS doctor away (2X reduction) – Nov 2016
- Multiple Sclerosis 2X more likely if vitamin D deficient as a fetus decades earlier – May 2016
- No multiple sclerosis relapses during pregnancy if 50,000 IU of Vitamin D weekly – RCT April 2015
- Season of birth associated with Pneumonia (10 %) and Multiple Sclerosis (30 %) – May 2013
- Multiple Sclerosis more likely if mother had less than 25 ng of vitamin D – Nov 2012
- Multiple Sclerosis 23 percent more likely if born in April vs. Oct – meta-analysis Nov 2012
- High vitamin D in moms decreased MS incidence in daughters by 40% – July 2011
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