Vitamin D Status and Long-Term Mortality in Community-Acquired Pneumonia: Secondary Data Analysis from a Prospective Cohort
PLOS One, July 1, 2016 http://dx.doi.org/10.1371/journal.pone.0158536
Jan C. Holter , Thor Ueland, Jon Norseth, Cathrine Brunborg, Stig S. Frøland, Einar Husebye, Pål Aukrust, Lars Heggelund
- Pneumonia patients 3 X more likely to die if low vitamin D – meta-analysis Sept 2017
- Hospital-acquired pneumonia treated by vitamin D if person was deficient – RCT Sept 2018
- Pneumonia is less frequent in people with more than 35 ng of vitamin D – Nov 2013
has the following chart
Breathing category starts with the following
- Search VitaminDWiki for "Respiratory Tract Infection" 482 items as of Sept 2017
- Search VitaminDWiki for Pneumonia 1,360 items as of July 2019
- Search VitaminDWiki for BRONCHITIS 272 items as of July 2019
- Search VitaminDWiki for ASTHMA in title 142 items - Nov 2019
- COPD Overview
- Search VitaminDWiki for Wheeze 1150 items as of Dec 2018
- Cystic Fibrosis category listing has
41 items along with related searches
- Air Pollution reduces Vitamin D
- Note: Air Pollution reduces UVB and keeps people indoors, both reduce Vitamin D
- Smoking reduces vitamin D
Supplementing with Vitamin D will improve the health of smokers and might decease craving
- Overviews at VitaminDWiki: Allergy Lung Cancer TB Asthma Influenza Colds and flu Pneumonia Respiratory infections
Low vitamin D status has been associated with short-term (30-day) mortality in hospitalized adults with community-acquired pneumonia (CAP). Data on its prevalence in these patients are scarce, and impact on long-term prognosis is unknown. We examined the prevalence of vitamin D deficiency and inadequacy and their effect on long-term mortality in hospitalized adults with CAP.
Secondary follow-up analysis of data from a prospectively recruited (January 2008–January 2011) well-defined cohort of 241 hospital survivors of CAP (Norway, latitude 60°N). Serum 25-hydroxyvitamin D levels, demographic, clinical, and laboratory data were measured within 48 hours of admission. The etiology of CAP was established in 63% of patients through extensive microbiological investigations. Mortality data were obtained from the national Cause of Death Registry. Explanatory strategy and Cox regression models were used to explore the association between vitamin D status and all-cause mortality.
Median age was 66 years. Eighty-seven (36%) patients were vitamin D deficient (<30 nmol/L), 81 (34%) were inadequate (30–49 nmol/L), and 73 (30%) were sufficient (=50 nmol/L). Seventy-two patients died over a median of 1839 days (range 1–2520 days), corresponding to cumulative 5-year survival rates of 66.2% (95% CI 56.2–76.2%), 77.0% (67.6–86.4%), and 77.8% (67.8–87.8%) for vitamin D deficient, inadequate, and sufficient patients, respectively. After adjusting for confounders (age, chronic obstructive pulmonary disease, immunocompromization and season), vitamin D deficiency, but not inadequacy, was significantly associated with higher mortality compared to patients with sufficiency (HR 1.91, 95% CI 1.06–3.45; P = .031).
There is a high prevalence of vitamin D deficiency and inadequacy among hospitalized adults with CAP. The results of this study also suggest that vitamin D deficiency is associated with an increased risk of mortality way beyond the short-term in these patients.
1737 visitors, last modified 16 Sep, 2018, URL:
- Air Pollution reduces Vitamin D