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How Vitamin D prevents Insulin Resistance – Sept 2020

The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders

Review Int J Mol Sci. 2020 Sep 11;21(18):E6644. doi: 10.3390/ijms21186644.
Izabela Szymczak-Pajor 1, Józef Drzewoski 2, Agnieszka Śliwińska 1


Many Complex Molecular Mechanism charts

Diabetes category starts with the following

537 items In Diabetes category   33+ Prediabetes studies   64+ Type 1 Diabetes studies

see also Overview Diabetes and vitamin D  Overview Metabolic Syndrome and vitamin D

Autoimmune category listing has 196 items along with related searches

Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 537 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

Number of articles in both categories of Diabetes and:
'This list is automatically updated''

  • Dark Skin 24;   Intervention 56;   Meta-analysis 38;   Obesity 35;  Pregnancy 44;   T1 (child) 39;  Omega-3 11;  Vitamin D Receptor 24;  Genetics 12;  Magnesium 27    Click here to see details

Some Diabetes studies

50 ng of Vitamin D fights Diabetes

T1 Diabetes


Diabetes, Metabolic Syndrome and Magnesium - many studies
Diabetic Epidemic

  • Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
    Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
    That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
    Chart from the web (2018?)

From the web



 Download the PDF from VitaminDWiki

Table of Contents

Numerous studies have shown that vitamin D deficiency is very common in modern societies and is perceived as an important risk factor in the development of insulin resistance and related diseases such as obesity and type 2 diabetes (T2DM). While it is generally accepted that vitamin D is a regulator of bone homeostasis, its ability to counteract insulin resistance is subject to debate. The goal of this communication is to review the molecular mechanism by which vitamin D reduces insulin resistance and related complications. The university library, PUBMED, and Google Scholar were searched to find relevant studies to be summarized in this review article. Insulin resistance is accompanied by chronic hyperglycaemia and inflammation. Recent studies have shown that vitamin D exhibits indirect antioxidative properties and participates in the maintenance of normal resting ROS level. Appealingly, vitamin D reduces inflammation and regulates Ca2+ level in many cell types. Therefore, the beneficial actions of vitamin D include diminished insulin resistance which is observed as an improvement of glucose and lipid metabolism in insulin-sensitive tissues.

Apart from mineral and bone metabolism regulation, vitamin D is also involved in a great number of cellular processes responsible for the homeostasis of glucose and lipid metabolism via insulin signaling pathway. Accumulating evidence supports that vitamin D deficiency is associated with the pathogenesis of insulin resistance. Disturbances in insulin signaling and inflammation are closely related, and vitamin D was found to reduce both of these disorders. Current evidence suggests that these benefits are the effect of vitamin D on Ca2+ and ROS homeostasis, as well as regulation of the expression of numerous genes. Considering multiple targets of vitamin D, we propose that pleiotropic action of vitamin D is a result of the crosstalk between insulin signaling and other signaling pathways governing metabolism, inflammation, immunomodulation, apoptosis, and adipogenesis. We have only just started to understand how vitamin D reduces insulin resistance and associated disorders. However, we would like to underline that although the awareness of vitamin D-associated health benefits is arising, the elevated consumption of vitamin D supplements may predispose to an increased incidence of vitamin D toxicity. Thus, without medical supervision, we advise caution for people who self-administrate higher than recommended doses of vitamin D.

Created by admin. Last Modification: Thursday September 17, 2020 11:27:01 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
14317 IR interactions.jpg admin 17 Sep, 2020 51.30 Kb 572
14316 Interactions.jpg admin 17 Sep, 2020 27.41 Kb 486
14315 Insulin R ToC.jpg admin 17 Sep, 2020 117.53 Kb 478
14314 Insulin Resistance_compressed.pdf admin 17 Sep, 2020 784.43 Kb 508