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Excessive insulin decreases vitamin D in 4 ways – problems for diabetic COVID-19 – Dec 2020

Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management

BMJ Open Heart 2020;7:e001356. doi: 10.1136/openhrt-2020-001356
Isabella D Cooper 1, Catherine A P Crofts 2, James J DiNicolantonio 3, Aseem Malhotra 4, Bradley Elliott1, Yvoni Kyriakidou1 and Kenneth H Brookler 5

VitaminDWiki

VitaminDWiki had wondered for 8 years why Diabetes seemed to consume Vitamin D.
It appears that Insulin decreases the amount of vitamin D which gets to the blood

Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 479 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
    • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

  • Dark Skin 23;   Intervention 52;   Meta-analysis 34;   Obesity 28;  Pregnancy 40;   T1 (child) 37;  Omega-3 11;  Vitamin D Receptor 21;  Genetics 11;  Magnesium 19    Click here to see details


Items in both categories Diabetes and Virus are listed here:

Items in both categories Gut and Probiotics are listed here:

See also VItaminDWiki

 Download the PDF from VitaminDWiki
Image

Risk factors for COVID-19 patients with poorer outcomes include pre-existing conditions: obesity, type 2 diabetes mellitus, cardiovascular disease (CVD), heart failure, hypertension, low oxygen saturation capacity, cancer, elevated: ferritin, C reactive protein (CRP) and D-dimer. A common denominator, hyperinsulinaemia, provides a plausible mechanism of action, underlying CVD, hypertension and strokes, all conditions typified with thrombi. The underlying science provides a theoretical management algorithm for the frontline practitioners.

Vitamin D activation requires magnesium.
Hyperinsulinaemia promotes:

  • magnesium depletion via increased renal excretion,
  • reduced intracellular levels,
  • lowers vitamin D status via sequestration into adipocytes and
  • hydroxylation activation inhibition.

Hyperinsulinaemia mediates thrombi development via:

  • fibrinolysis inhibition,
  • anticoagulation production dysregulation,
  • increasing reactive oxygen species,
  • decreased antioxidant capacity via nicotinamide adenine dinucleotide depletion,
  • haem oxidation and catabolism,
  • producing carbon monoxide,
  • increasing deep vein thrombosis risk and pulmonary emboli.

Increased haem-synthesis demand upregulates carbon dioxide production, decreasing oxygen saturation capacity. Hyperinsulinaemia decreases cholesterol sulfurylation to cholesterol sulfate, as low vitamin D regulation due to magnesium depletion and/or vitamin D sequestration and/or diminished activation capacity decreases sulfotransferase enzyme SULT2B1b activity, consequently decreasing plasma membrane negative charge between red blood cells, platelets and endothelial cells, thus increasing agglutination and thrombosis.

Patients with COVID-19 admitted with hyperglycaemia and/or hyperinsulinaemia should be placed on a restricted refined carbohydrate diet, with limited use of intravenous dextrose solutions. Degree/level of restriction is determined by serial testing of blood glucose, insulin and ketones. Supplemental magnesium, vitamin D and zinc should be administered. By implementing refined carbohydrate restriction, three primary risk factors, hyperinsulinaemia, hyperglycaemia and hypertension, that increase inflammation, coagulation and thrombosis risk are rapidly managed.


Created by admin. Last Modification: Sunday December 13, 2020 18:26:02 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
14712 Hyper1.jpg admin 12 Dec, 2020 22:00 146.86 Kb 185
14711 hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19 pp.pdf PDF 2020 admin 12 Dec, 2020 21:59 2.04 Mb 101
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