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How Vitamin D Helps Fight COVID-19 - Grassroots Health Oct 2020

Part 1 Oct 2, 2020


Vitamin D deficiency has now been shown to increase susceptibility to COVID-19 and increase the risk of COVID-19 severity, including ICU admission and death. Conversely, other published studies have also shown those with higher vitamin D levels (over 30 ng/ml or 75 nmol/L) have a reduced risk of severe symptoms and death due to COVID-19. In fact, an analysis of over 190,000 Americans found that having vitamin D levels of at least 50 ng/ml resulted in a 53% lower positivity rate than those whose levels were less than 20 ng/ml! The first-published randomized controlled trial on vitamin D and COVID-19 found that adding vitamin D to the standard treatment nearly eliminated ICU admissions and did eliminate deaths.
 
It sounds almost too good to be true... Yet vitamin D is known to influence the expression of thousands of genes and is involved in regulating over 80 biological pathways in the body. Vitamin D is not a miracle drug, nor does it act alone, but it is an important mediator of immune function, and we can largely control whether or not we get enough vitamin D from our daily habits (sun, diet and supplements). 
 
Today we will explain HOW vitamin D acts to protect you from getting COVID-19, and in an upcoming Part 2, we will discuss how vitamin D helps improve symptoms if you do get COVID-19. 

 


Vitamin D is Known to Help Prevent Upper Respiratory Tract Infections

 


Vitamin D is known to help fight upper respiratory tract infections. As previously discussed, a large meta-analysis including 25 randomized controlled trials with over 11,300 individuals showed that vitamin D supplementation reduced the risk of respiratory tract infections by 70%. GrassrootsHealth participants with vitamin D levels greater than or equal to 40 ng/mL were 41% less likely to have had the flu and 15% less likely to have had a cold in the prior 6 months than participants with levels less than 20 ng/mL.  
 
Acute Respiratory Distress Syndrome (ARDS) is a major complication and cause of death among those with serious COVID-19 infections. When comparing vitamin D levels among those with and at risk of ARDS, one study found that 96% of those at risk of ARDS were deficient in vitamin D.

 


Vitamin D Can Protect Lung Cells from SARS-CoV-2 Attack

 


COVID-19 is caused by a coronavirus (a specific type of virus) called SARS-CoV-2. Infection of COVID-19 begins when the SARS-CoV-2 virus enters the cells of the lung by binding the angiotensin-converting enzyme 2 (ACE-2) receptor and de-activating it, resulting in inflammation. Vitamin D is responsible for increasing ACE-2 expression, which allows it to carry out its anti-inflammatory actions to help protect the lungs and keep inflammation at bay. 
 
During the early incubation stage when the virus is hijacking the cell there are generally no symptoms. Most people who are infected with SARS-CoV-2 experience mild-moderate respiratory symptoms and recover without any need for hospitalization or therapy. In those who do experience more severe symptoms, only a small percentage have severe enough symptoms for the virus to be life threatening. This difference in both susceptibility (whether the virus is able to invade) and recovery (how well the body fights it off if it does invade) is attributed to the individual’s immune response. Vitamin D may help protect against COVID-19 specifically through maintenance of physical barriers (susceptibility) and regulation of innate and adaptive immunity (mounting an effective immune response to the virus). 
 
The graphic below provides a very clear illustration of several ways vitamin D acts to directly protect the lungs, from its effect on the protective barrier of the lungs, to its involvement in the maturation of immune cells, and its role in regulating the inflammatory response and inhibiting the cytokine storm (which will be covered in more detail in Part 2).

 


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Vitamin D Regulates the Immune Response

 


Vitamin D plays a crucial role in regulating immune system activity – both innate and adaptive responses. As previously described, the innate immune system is responsible for the initial defensive front with a central role played by phagocytes. Vitamin D stimulates expansion of these phagocytes (monocytes and macrophages) increasing their ability to fight off the virus by increasing their numbers, as well as increasing their killing capacity through stimulating the production of the anti-viral protein cathelicidin. Vitamin D also acts to regulate the maturation of dendritic cells which are important for activating CD4+ T cells and in turn the rest of the immune response.
 
Earlier studies have shown that in SARS and influenza the adaptive immune cells, T cells and B cells, are vital in defending the body against the virus. Many studies have found this to be the case in COVID-19 as well, with both antibody and cellular defenses being recruited to the fight. Vitamin D is a potent regulator of adaptive immunity, including both cell-mediated (T cell) and humoral (B cell) immunity

 


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Cox R and Brokstad K, Nature Reviews, 2020.
Click to Download & Print

 


Once SARS-CoV-2 has been successful at replicating itself and spreading to surrounding cells, mild to moderate symptoms progress (e.g. sore throat, cough, fever and muscle aches) that result from localized and appropriate inflammation, associated tissue damage and antiviral activity of B cells and T cells. CD4+ and CD8+ T cells secrete cytokines (chemical signals that instruct other cells what to do) and are central to the successful elimination of COVID-19, as happens in most people. Unfortunately, more serious symptoms and death can result with an over-reactive or ineffective immune response, as can happen when there is not enough vitamin D for use. The role of vitamin D at this stage will be covered in Part 2.
 
Thus, vitamin D is important to help fend off an attack by SARS-CoV-2. Ensuring optimal levels of vitamin D is an easy way to help support your immune system response.

 


Better Results when Taken Together

 


Nutrients work synergistically in order to carry out specific functions within the body. For example, we have recently discussed how different immune cells rely on a variety of nutrients, including vitamins D, C, B6, B12, zinc, and magnesium, in order to carry out their actions in an immune response. Without these necessary nutrients, immune function may be hindered.
 
Could a nutrient deficiency be putting a damper on your immune response? Find out by testing your vitamin D, omega-3s, magnesium and other essential elements (including selenium), as well as your inflammation levels, with the new Immune Boost home test kit offered by GrassrootsHealth. Measuring levels is the only way to know if you are supporting your immune system and whether additional changes should be made, with supplementation, dietary changes, or both.


Part 2 Oct 9, 2020


 
 
 
 
 
 
 
 

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Vitamin D is used by every cell of the body, influences the expression of thousands of genes, and is involved in regulating over 80 biological pathways – importantly, vitamin D is a potent regulator of immune function. However, it may still be surprising how much one vitamin can influence the body’s response to a COVID-19 infection. Vitamin D deficiency has now been shown to increase susceptibility to COVID-19 and increase the risk that if you do have COVID-19, it will be severe enough to require hospitalization in the ICU and lead to death. Conversely, published studies have also shown reduced risk of severe symptoms and death due to COVID-19 with higher vitamin D levels (over 30 ng/mL). In fact, an analysis of over 190,000 Americans found that having a vitamin D level of at least 50 ng/ml resulted in a 53% lower positivity rate for SARS-CoV-2 infection than those with levels less than 20 ng/ml! The first-published randomized controlled trial on vitamin D and COVID-19 found that adding vitamin D to the standard treatment nearly eliminated ICU admissions and did eliminate deaths

In Part 1 we reviewed how vitamin D acts to protect against COVID-19. Today we will describe how vitamin D influences the immune system in ways that are beneficial, such as preventing the hyper-inflammatory response characteristic of severe COVID-19 infection. 


Vitamin D Regulates the Immune Response

Vitamin D plays a crucial role in regulating immune system activity – both innate and adaptive responses. As described in Part 1, vitamin D increases the innate immune response and may help reduce entry of SARS-CoV-2 into cells in the lung and reinforce the physical barriers, or junctions, between cells, which in turn may help prevent the spread of the virus between cells. Vitamin D also stimulates expansion of phagocytes (monocytes and macrophages) increasing their ability to fight off the virus by numbers. In addition, vitamin D directly stimulates phagocytes and lung cells to produce anti-viral proteins, cathelicidin and defensins, that kill the virus. However, an appropriate adaptive immune response is a vital part of the body’s defense against SARS-CoV-2. Vitamin D is a potent regulator of adaptive immunity, including both cell-mediated (T cell) and humoral (B cell) immunity. Vitamin D is needed by these white blood cells to help them recognize, bind to, and destroy SARS-CoV-2.

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Click to Enlarge & Print

What Causes A Severe SARS-CoV-2 Infection?

Once SARS-CoV-2 has been successful at replicating itself and spreading to surrounding cells, mild to moderate symptoms progress (e.g. sore throat, cough, fever and muscle aches) as part of a normal immune response to the virus. CD4+ and CD8+ T cell responses including secreted inflammatory cytokines are central to the successful elimination of COVID-19, as happens in most people.
 
However, in some people the immune response goes awry at this point and generates a hyper-inflammatory state referred to as the “cytokine storm” as depicted in the diagram below. The cytokine storm is the leading theory that explains why some people have a severe reaction to coronaviruses while others only experience mild symptoms. Moderate levels of inflammation are associated with mild-moderate symptoms of COVID-19, whereas the cytokine storm generates a hyper-inflammatory state associated with severe COVID-19 symptoms.

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Click to Enlarge & Print

The cytokine storm results from a sudden acute increase in circulating levels of different pro-inflammatory cytokines including IL-6, IL-1, TNF- a, and interferon produced mostly by T cells. These inflammatory cytokines, in addition to the ongoing replication and spread of the virus, trigger more immune cell involvement and tissue damage that leads to acute respiratory distress, multiple organ failure and possibly death. By dampening the cytokine storm, we can reduce the severity of symptoms and the risk of death.

Vitamin D Helps Control the Cytokine Storm and Reduce Symptom Severity

Vitamin D acts in many ways to regulate the adaptive immune response. Vitamin D stimulates CD4+ T cell proliferation and cytokine production, and antibody activity (B cells). Vitamin D acts to regulate T cell response through initiating dendritic cell tolerance. These dendritic cells in turn stimulate the increased production of T regulatory (Treg) cells and their production of anti-inflammatory interleukin (IL)-10, switching the response from being Th1-driven and pro-inflammatory to a Th2-driven anti-inflammatory response.
 
Vitamin D acts to suppress the production of inflammatory cytokines (such as IL-1, IL-6 and IFN which are predominant in the cytokine storm characteristic of severe COVID-19). Vitamin D also has an effect on the actions of B-cells and inhibits the production of antibodies. Overall, the immunomodulatory actions of vitamin D play a very important role in preventing the activation of an inappropriate hyper-inflammatory immune response.
 
Because the virus also binds ACE-2 receptors it interrupts the renin-angiotensin system, responsible for regulating blood volume, a pathway that is also regulated by vitamin D. Ensuring sufficient vitamin D may improve response to the virus in the lungs and lessen the impact of SARS-CoV-2 infection on reduced levels of surfactant (a liquid secretion that allows the lungs to open and fill with air) which may then reduce the impact of SARS-CoV-2 infection on the ability to breathe.
 
Thus, vitamin D is important to help regulate the immune response to a SARS-CoV-2 infection. Ensuring optimal levels of vitamin D is a safe and easy way to help support your immune response.

Do you know your vitamin D level?

Measure your vitamin D level today! When you know what your level is, you can determine next steps to take and how much supplementation may be needed if you are below your target level. A panel of 48 International Vitamin D scientists recommend a level between 40-60 ng/ml (100-150 nmol/L) - where are you?

See also in VitaminDWiki

COVID-19 news
COVID-19 and Dark Skins
COVID-19 treated by Vitamin D - studies, reports, videos
Contents as of Oct 30:

  • 33 trials, 1 trial result, 28 observations, 9 recommendations, 34 associations, 74 speculations, 25 videos

and has the following recent updates

Top Vitamin D and COVID-19 recent updates

Click on chart for details

Search Google Scholar for COVID-19 Vitamin D 20,000 publications Oct 10, 2020


Many clinical trials are underway which are testing Vitamin D to fight COVID-19

COVID-19 RCTs


50 most-recently changed items in Virus Category in VitaminDWiki

Id Page Hits Last modification Creator Categories
12035 COVID-19 death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020 48
30 Oct, 2020 12:17
admin Virus
11728 COVID-19 treated by Vitamin D - studies, reports, videos 13876
30 Oct, 2020 12:11
admin Virus
11753 More Vitamin K and formented food associated with fewer COVID-19 problems 1328
30 Oct, 2020 10:50
admin Vitamin D and Vitamin K
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12032 Vitamin C may treat COVID-19 (several studies) 42
29 Oct, 2020 20:48
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12033 Systems Thinking About SARS-CoV-2 - Oct 2020 42
29 Oct, 2020 20:39
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12028 Concise summary of 10 Vitamin D and COVID-19 observations - Oct 27, 2020 96
29 Oct, 2020 10:05
admin Virus
12026 COVID-19 patients who happened to be taking Vitamin D did much better – Oct 27,2020 149
28 Oct, 2020 16:07
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12025 COVID-19 was killing dark-skinned doctors, then they got a Vitamin D recommendation 260
28 Oct, 2020 14:18
admin Skin - Dark
Virus
11727 COVID-19 more frequent and deadly for those with dark skins (high risk of low vitamin D) 4142
28 Oct, 2020 00:59
admin Skin - Dark
Virus
12023 Zinc (which increases vitamin D in tissues) may both prevent and treat COVID-19 130
27 Oct, 2020 22:18
admin Virus
Zinc
12024 Can vitamin D fight COVID-19 - interview of Dr. Matthews Oct 2020 126
27 Oct, 2020 10:36
admin Books, videos on Vitamin D
Virus
11998 Vitamin D could knock out COVID-19 in 3 months – Dr. Matthews interview Oct 2020 258
27 Oct, 2020 00:35
admin Skin - Dark
Virus
12021 Magnesium (which increases vitamin D) may fight COVID-19 - Oct 2020 251
26 Oct, 2020 20:16
admin Vitamin D and Magnesium
Virus
11580 COVID-19 Coronavirus can most likely be fought by Vitamin D 261326
26 Oct, 2020 14:34
admin Virus
11787 Does vitamin D (and C) help with Covid-19 - May 2020 988
22 Oct, 2020 12:29
admin Virus
12019 19X less COVID-19 infection if innate immune system activated – trial Oct 21, 2020 323
21 Oct, 2020 18:52
admin Immunity
Virus
12013 COVID-19 associated with low Vitamin D in China in the Spring - Sept 2020 129
18 Oct, 2020 13:02
admin Virus
12007 AI is examining 170,000 potential COVID-19 treatments, Vitamin D is one of only 6 found – Sept 4, 2020 568
18 Oct, 2020 09:48
admin Vitamin D Receptor
Virus
12010 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020 552
16 Oct, 2020 23:30
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12012 COVID-19 and Vitamin D - 14 studies as of Oct 16, 2020 168
16 Oct, 2020 16:33
admin Virus
12009 COVID-19 fought by Vitamin D in 43 studies - Oct 15, 2020 318
15 Oct, 2020 16:10
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11795 COVID-19 resulted in 3.7X decrease in Irish Very Low Weight Births (Vitamin D) - June 2020 569
15 Oct, 2020 15:29
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Virus
3780 Vitamin D can inhibit enveloped virus (e.g. Herpes, Zoster, Epstein, Hepatitis, Ebola) – March 2011 41181
15 Oct, 2020 10:54
admin Virus
5894 Vitamin D and the anti-viral state – March 2010 3553
15 Oct, 2020 10:35
admin Virus
11681 Vitamin D supplementation could prevent and treat influenza, CORONAVIRUS, and pneumonia infections - March 2020 3948
15 Oct, 2020 10:31
admin Virus
11749 COVID-19 association with Vitamin D also being explored by Hollis and Wagner - April 2020 1260
15 Oct, 2020 10:29
admin Virus
11716 Global Push for RCTs in COVID-19 - April 4, 2020 636
15 Oct, 2020 10:26
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11707 Preventing a COVID-19 pandemic with Vitamin D – Grant April 2020 1527
15 Oct, 2020 10:15
admin Virus
10823 How Vitamin D helps fight the cold, flu and other viruses - June 2019 502
15 Oct, 2020 10:10
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Virus
7470 Many Infectious diseases (virus) treated and prevented by Vitamin D – review July 2009 4424
15 Oct, 2020 10:03
admin Immunity
Intervention
Virus
11958 Rate of COVID-19 test positive is 40 pcnt lower if high vitamin D (192,000 people) - Holick Sept 2020 632
15 Oct, 2020 00:05
admin Skin - Dark
Virus
11985 How Vitamin D Helps Fight COVID-19 - Grassroots Health Oct 2020 300
14 Oct, 2020 15:59
admin Virus
12006 COVID-19 antibodies 2.6 X more likely if had symptoms and low vitamin D (UK hospital staff)– Oct 5 2020 230
11 Oct, 2020 19:32
admin Skin - Dark
Virus
12005 Vaccines are plan A for COVID-19 Immunity (no plan B) - Sept 11, 2020 204
10 Oct, 2020 17:58
admin Virus
12004 15 studies indicating that Vitamin D fights COVID-19 - Dr. Grimes Oct 9, 2020 1294
10 Oct, 2020 15:03
admin Virus
12000 UK parliament members starting to be interested in Vitamin D for COVID-19 – Oct 10, 2020 264
10 Oct, 2020 13:01
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Virus
11698 COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020 1097
07 Oct, 2020 15:02
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Diabetes
Hypertension
Virus
11996 Diabetes increases COVID-19 severity and COVID-19 creates Diabetes - Oct 2020 114
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Virus
11992 11 family members got COVID-19 due to one teen in 3 weeks – CDC Oct 5, 2020 149
06 Oct, 2020 15:57
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Virus
11927 Swine flu not prevented by 2,000 IU of vitamin D daily (the upper limit at the time) – RCT 2014 269
06 Oct, 2020 15:57
admin Youth
Intervention
Virus
11991 Children with low vitamin D far more likely to hospitalized with COVID-19 – Oct 2020 125
06 Oct, 2020 15:55
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Infant-Child
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11990 VITAMIN D AND COVID-19: IT IS TIME TO ACT – Oct 4, 2020 191
06 Oct, 2020 11:17
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11988 32X more likely to have severe-critical COVID-19 in Turkish hospital if Vitamin D deficient – Oct 5, 2020 292
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11987 2.3 X increase in COVID-19 death if mentally ill (associations: Mental Illness and Low Vitamin D, Low D and COVID-19 ... 165
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11983 20,000 COVID-19 infections at Amazon (far less than US average of 34,000) – Oct 1, 2020 159
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11982 COVID-19 was predicted in 2017, now even deadlier predictions are being made, but still no one is listening - Sept 2020 204
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7499 Virus 21250
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11981 Can vitamin D supplements help protect against COVID-19 - Oct 1, 2020 205
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admin Virus
11978 Sleep Apena patents are 5X more likely to have a COVID-19 infection requiring hospitalization - Sept 28, 2020 217
29 Sep, 2020 20:32
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11977 COVID-19, flu, virus, Selenium, Vitamin D, Glutathione - Interview Sept 2020 205
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admin Virus

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