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Epstein-Barr Virus increases the risk of many health problems – many studies


Epstein-Barr virus infection in the development of neurological disorders - 2020

Drug Discovery Today: Disease Models Volume 32, Part A, Autumn 2020, Pages 35-52 https://doi.org/10.1016/j.ddmod.2020.01.001
Samantha S.Soldan ssoldan at wistar.org. Paul M.Lieberman

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Epstein-Barr Virus (EBV) is a ubiquitous human herpesvirus that contributes to the etiology of diverse human cancers and auto-immune diseases. EBV establishes a relatively benign, long-term latent infection in over 90 percent of the adult population. Yet, it also increases risk for certain cancers and auto-immune disorders depending on complex viral, host, and environmental factors that are only partly understood. EBV latent infection is found predominantly in memory B cells, but the natural infection cycle and pathological aberrations enable EBV to infect numerous other cell types, including
oral, nasopharyngeal, and gastric epithelia, B-, T-, and NK-lymphoid cells, myocytes, adipocytes, astrocytes, and neurons.
EBV infected cells, free virus, and gene products can also be found in the CNS. In addition to the direct effects of EBV on infected cells and tissue, the effect of chronic EBV infection on the immune system is also thought to contribute to pathogenesis, especially auto-immune disease. Here, we review properties of EBV infection that may shed light on its potential pathogenic role in neurological disorders.
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Epstein-Barr Virus and Neurological Diseases - Jan 2022

Front Mol Biosci. 2021; 8: 816098. doi: 10.3389/fmolb.2021.816098
Nan Zhang, 1 , 2 Yuxin Zuo, 1 Liping Jiang, 1 Yu Peng, 1 Xu Huang, 1 and Lielian Zuo 1 ,*

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Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a double-stranded DNA virus that is ubiquitous in 90–95% of the population as a gamma herpesvirus. It exists in two main states, latent infection and lytic replication, each encoding viral proteins with different functions. Human B-lymphocytes and epithelial cells are EBV-susceptible host cells. EBV latently infects B cells and nasopharyngeal epithelial cells throughout life in most immunologically active individuals. EBV-infected cells, free viruses, their gene products, and abnormally elevated EBV titers are observed in the cerebrospinal fluid. Studies have shown that EBV can infect neurons directly or indirectly via infected B-lymphocytes, induce neuroinflammation and demyelination, promote the proliferation, degeneration, and necrosis of glial cells, promote proliferative disorders of B- and T-lymphocytes, and contribute to the occurrence and development of nervous system diseases, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, acute cerebellar ataxia, meningitis, acute disseminated encephalomyelitis, and brain tumors. However, the specific underlying molecular mechanisms are unclear. In this paper, we review the mechanisms underlying the role of EBV in the development of central nervous system diseases, which could bebeneficial in providing new research ideas and potential clinical therapeutic targets for neurological diseases.
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The Virus That Causes Mono Does a Lot More Than That - March 2022

The Atlantic
autoimmune disorders such as rheumatoid arthritis, lupus, and multiple sclerosis
cancers, chronic fatigue.

  • "The recent study from Harvard’s Ascherio got around this by looking at a massive archive of serum samples taken from people over 20 years. The collection came from the Department of Defense, which stores serum from routine tests for HIV. Among the 10 million adults with samples in the repository, researchers were able to find enough people who were initially negative for EBV but then contracted it during the 20-year period. And those who did get the virus were 32 times as likely to develop multiple sclerosis as those who did not. A second study from Stanford adds a possible causation to this correlation: Some multiple-sclerosis patients have antibodies that bind both an EBV protein and a protein in the brain, which is erroneously targeted by the immune system in multiple sclerosis. This kind of cross-reaction has long been suspected in MS but only now identified. “It’s just like a great volcano of information,” says Rickinson about the recent studies. As with EBV-associated cancers, though, only a tiny sliver of people infected with the virus end up developing multiple sclerosis, so some other trigger or triggers must also be in play. We’re only at the beginning of understanding this process."
  • "And in the 1980s, doctors noticing the similarity had begun diagnosing chronic Epstein-Barr virus syndrome in patients whose mono-like symptoms of fatigue and sore throat did not go away for months. Eventually, however, experts took Epstein-Barr out of the name and gave it the more general term of chronic fatigue syndrome, because EBV does not seem to be the sole cause of such symptoms."

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EBV caused 137,900 – 208,700 cancer deaths (1% of total) in 2020

Estimating the global burden of Epstein–Barr virus-related cancers - Oct 2021
Nasopharyngeal carcinoma, Gastric carcinoma, Hodgkin lymphoma, Burkitt lymphoma, Diffuse large B-cell lymph, Extranodal NK/T-cell lymphoma, Nasal type
Note by VitaminDWiki other viruses cause other cancer deaths.
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13+ VitaminDWiki titles contaning EPSTEIN oR EBV

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See also Long-COVID is now the biggest COVID concern - many studies

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17147 EBV Cancers 2021.pdf admin 03 Mar, 2022 17:14 739.19 Kb 95
17145 EBV Atlantic March 2022.pdf PDF 2022 admin 03 Mar, 2022 14:32 1.87 Mb 97
17070 EBV 2022.jpg admin 19 Feb, 2022 21:33 149.79 Kb 309
17069 Epstein-Barr Virus and Neurological Diseases.pdf PDF 2022 admin 19 Feb, 2022 21:27 1.34 Mb 102
17068 EBV lifetime.jpg admin 19 Feb, 2022 21:13 101.98 Kb 302
17067 EBV lifetime consequences.pdf PDF 2020 admin 19 Feb, 2022 21:12 1.43 Mb 144