Lifetime serum concentration of 25-hydroxyvitamin D 25(OH) is associated with hand grip strengths: insight from a Mendelian randomisation
Age Ageing. 2022 Apr 1;51(4):afac079. doi: 10.1093/ageing/afac079. PDF is behind a $52 paywall
Mohsen Mazidi 1, Ian G Davies 2, Peter Penson 3, Toni Rikkonen 4, Masoud Isanejad 4
Clinical trials have suggested that increased 25-hydroxyvitamin D (25(OH)D) has positive effect on hand grip strength. This Mendelian randomisation (MR) was implemented using summary-level data from the largest genome-wide association studies on vitamin D (n = 73,699) and hand grip strength. Inverse variance weighted method (IVW) was used to estimate the causal estimates. Weighted median (WM)-based method, MR-Egger and leave-one-out were applied as sensitivity analysis. Results showed that genetically higher-serum 25(OH)D levels had a positive effect on both right hand grip (IVW = Beta: 0.038, P = 0.030) and left hand grip (IVW = Beta: 0.034, P = 0.036). There was a low likelihood (statistically insignificant) of heterogeneity and pleiotropy, and the observed associations were not driven by single single-nucleotide polymorphisms. Furthermore, MR pleiotropy residual sum and outlier did not highlight any outliers. In conclusion, our results highlighted the causal and beneficial effect of serum 25(OH) D on right- and left-hand grip strengths.
VitaminDWiki pages with HANDGRIP in title (5 as of April 2022)
This list is automatically updated
Items found: 6
VitaminDWiki pages with STRENGTH but not EVIDENCE in title (43 as of April 2022)
This list is automatically updated
Items found: 50
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Athletic strength improved by Vitamin D – meta-analysis May 2024 |
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13 Aug, 2024 |
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The Great Osteoporosis Scam (improve bone density (DXA) instead of bone strength – follow the money) – July 2024 |
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20 Jul, 2024 |
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Muscle strength improved with Calfidediol (a form of vitamin D) - meta-analysis May 2022 |
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29 Feb, 2024 |
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2,000 IU of Vitamin D per kg of food – best growth, bone strength, etc. (pig trial) – Dec 2022 |
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24 Dec, 2023 |
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Female preemies become women with low hand grip strength - Dec 2023 |
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24 Dec, 2023 |
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More muscle strength 80 years after being born in warm season (no surprise) – Nov 2022 |
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26 Nov, 2022 |
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Grip strength of children not improved by 800 IU Vitamin D daily (not nearly enough) – RCT Feb 2018 |
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31 Oct, 2022 |
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Age-related loss of strength (Dynapenia) 1.7X more likely if low Vitamin D – Sept 2022 |
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16 Sep, 2022 |
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Better handgrip strength if some good vitamin D genes (or if supplement) – April 2022 |
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09 Apr, 2022 |
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Handgrip strength increased 9 percent in college athletes with 8 weeks of Omega-3 – RCT Feb 2022 |
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18 Mar, 2022 |
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Muscle Strength improved 1.4 to 19 percent by vitamin D3 (not D2) – systematic review June 2016 |
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13 Feb, 2022 |
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Loss of muscle strength –sarcopenia – one of the suspects is vitamin D – Aug 2012 |
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16 Oct, 2021 |
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Exercise improves bone strength (good), but not bone mineral density (can be measured) – RCT Oct 2021 |
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08 Oct, 2021 |
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Low muscle strength predicts low vitamin D level in elderly – March 2021 |
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06 May, 2021 |
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Grip strength following wrist fracture increased by 50,000 IU Vitamin D monthly – May 2019 |
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09 May, 2019 |
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Vitamin D supplementation increases strength of lower muscles – Meta-analysis April 2019 |
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01 May, 2019 |
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Bone STRENGTH improved by 2800 IU of Vitamin D (not bone density) – RCT Oct 2018 |
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06 Oct, 2018 |
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Seniors getting Vitamin D (but no exercise) for 3 months failed to increase muscle strength – RCT June 2018 |
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03 Jul, 2018 |
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Poor handgrip strength in 5-year-old girls 3X more likely if low vitamin D – May 2018 |
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24 May, 2018 |
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Vitamin D weekly supplementation (Spinal Cord Injury athletes) increased handgrip strength – May 2018 |
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15 May, 2018 |
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Osteoporosis and low grip strength both associated with low vitamin D – Feb 2018 |
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13 Feb, 2018 |
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Vitamin D improves muscle strength, reduces falling, and reduces frailty – review March 2015 |
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27 Jul, 2017 |
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Muscle strength not increased by Vitamin D - 96 percent were not deficient – RCT April 2017 |
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20 Jul, 2017 |
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Muscle strength not increased by Vitamin D when 96 percent already had enough – RCT April 2017 |
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30 Apr, 2017 |
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Strength of evidence for Vitamin D – July 2014 |
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26 Apr, 2017 |
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Muscle strength of senior women increased 25 percent with vitamin D, decreased 6 percent with placebo – Oct 2016 |
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08 Mar, 2017 |
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Handgrip strength dropped by 20 percent in the last generation (perhaps due to lower vitamin D) - Feb 2017 |
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02 Mar, 2017 |
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Vitamin D increased muscle strength by 1% to 19% (varied with dose and duration) – review June 2016 |
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22 Nov, 2016 |
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Vitamin D increased muscle strength by 1 to 19 percent – review June 2016 |
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22 Nov, 2016 |
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Vitamin D increasing muscle strength may reduce knee pain – Feb 2016 |
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22 Nov, 2016 |
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Muscle strength is associated with vitamin D receptor gene variants – March 2016 |
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12 Nov, 2016 |
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Vitamin D supplementation improves muscle strength in healthy adults – meta-analysis of 6 RCT Aug 2014 |
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31 Oct, 2016 |
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Muscle strength of Judo athletes increased 13 percent following single dose of 150,000 IU vitamin D – RCT Nov 2015 |
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05 Nov, 2015 |
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Bone strength (more accurate than BMD) is inversely associated with vitamin D level – May 2015 |
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30 May, 2015 |
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Bone strength increased when sow and piglets had enough Vitamin D and Phosphorus – April 2015 |
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07 Apr, 2015 |
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Pelvic floor muscle strength is low after giving birth if vitamin D deficient – March 2015 |
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20 Mar, 2015 |
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People with old burns improved muscle strength with 2200 IU average vitamin D – RCT Sept 2014 |
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20 Dec, 2014 |
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Increased Bone strength during military training – with just 800 IU of vitamin D and Calcium – RCT April 2014 |
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29 Apr, 2014 |
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Ankle strength and vitamin D lowest in winter, and were associated with more elderly falls – May 2012 |
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09 Mar, 2014 |
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Elderly lower limb muscle strength improved with Vitamin D supplementation - Meta-analysis Oct 2013 |
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23 Dec, 2013 |
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Vitamin D improves muscle strength if deficient – meta-analysis - Oct 2010 |
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19 Dec, 2013 |
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Muscle strength not increased by raising vitamin D to only 30 ng – RCT Aug 2012 |
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19 Dec, 2013 |
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Muscle strength in youth increased with 60,000 IU vitamin D per week and 1 g Calcium – April 2010 |
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10 Aug, 2013 |
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Vitamin K-2 (180 ug MK-7) helped both bone density and strength – RCT March 2013 |
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18 Apr, 2013 |
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National Standard summary and strength of evidence for vitamin D - June 2010 |
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10 Nov, 2012 |
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Vitamin D2 intervention increased elderly muscle strength – Nov 2010 |
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10 Nov, 2012 |
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National Institute of Health - Strength of Vitamin D Evidence |
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07 Nov, 2011 |
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Lack of vitamin D and Calcium a world problem – strength of evidence etc – 2009 |
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29 Sep, 2011 |
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Higher vitamin D helps regain muscle strength after knee surgery – July 2011 |
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01 Sep, 2011 |
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Strength of evidence for Calcium at NLM – Oct 2010 |
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09 Oct, 2010 |
Some diseases restrict vitamin D by changing gene activation,
by one or more of the following
- Restrict conversion of light into vitamin D in the skin
- Restrict oral absorption in the gut
- Restrict semi-activation in the liver
- Restrict free semi-activated vitamin D from getting to the kidneys
- Restrict full activation in the kidneys
- Restrict semi and fully activation in the cells
- Restrict activated Vitamin D from entering cell mitochondria (VDR)
- Destroy the vitamin D before it gets to the cells
Some diseases restrict vitamin D without changing genes
- The disease just uses/consumes the vitamin D
- The disease upsets the gut, which reduces bioavailability of oral form
- unless a gut-friendly form is used
References