A meta-analysis on associations between vitamin D receptor genetic variants and tuberculosis.
Microb Pathog. 2019 Feb 26. pii: S0882-4010(19)30022-1. doi: 10.1016/j.micpath.2019.02.027.
Wang Y1, Li HJ2.
1 Clinical Laboratory, Huzhou Central Hospital, Huzhou, Zhejiang, China. wytg2019@sina.com.
2 Clinical Laboratory, Zhuantang Street Community Health Service Center of Xihu District, Hangzhou, Zhejiang, China. hongjieli8896@163.com.
Items in both categories TB and Vitamin D Receptor gene are listed here:
- TB patients had low Vitamin D and poor Vitamin D receptor – June 2019
- TB and Leprosy are easily confused and associated with Vitamin D Receptor
- Certain types of Tuberculosis are 2X more likely with a poor Vitamin D Receptor – April 2019
- Tuberculosis increased risk if poor Vitamin D receptor varies by race – meta-analysis Feb 2019
- Pulmonary Tuberculosis 2X more likely if poor Vitamin D Receptor (Mexico) – April 2018
- TB risk in Blacks increased 20 percent having poor Vitamin D Receptors – Sept 2017
- Tuberculosis 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Oct 2016
- Tuberculosis, genes and vitamin D – Meta-Analysis Dec 2013
Items in both categories TB and Meta-analysis are listed here:
- Latent Tuberculosis 44 percent less likely if Vitamin D more than 30 ng - 14th meta-analysis Jan 2022
- Those with TB were 3.2 X more likely to have low vitamin D – 13th meta-analysis Sept 2021
- Tuberculosis still associated with low vitamin D – 12th meta-analysis June 2021
- Tuberculosis 3X more likely if less than 12 ng of Vitamin D - meta-analysis Sept 2019
- Tuberculosis increased risk if poor Vitamin D receptor varies by race – meta-analysis Feb 2019
- Tuberculosis (multi-drug resistant) was 13.4 X more likely to be quickly cleared with Vitamin D - Meta-analysis Feb 2019
- Catching Tuberculosis from family member 2 X more likely if low vitamin D – meta-analysis Dec 2018
- Tuberculosis in children 1.7 X more likely if low vitamin D – meta-analysis Aug 2018
- Low vitamin D is a risk factor for tuberculosis – meta-analysis Dec 2016
- Tuberculosis 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Oct 2016
- Tuberculosis 4.5X more likely if vitamin D less than 10 nanogram – meta-analysis May 2015
- Tuberculosis, genes and vitamin D – Meta-Analysis Dec 2013
- TB associated with low vitamin D in a review and meta-analysis – 2008
- TB and vitamin D updated review and meta-analysis – plays a role Jan 2010
Download the PDF from Sci-Hub via VitaminDWiki
OR, odds ratio; CI, confidence interval; NA, not available; PTB, pulmonary tuberculosis; EPTB, extrapulmonary tuberculosis.
The values in bold indicate that there are statistically significant differences between cases and controls.
Abstract
OBJECTIVES: We aimed to analyze potential associations between vitamin D receptor (VDR) genetic variants and tuberculosis (TB) through a meta-analysis.
METHODS: Systematic literature research of PubMed, Web of Science, Embase and CNKI was performed to identify eligible articles. Statistical analyses were conducted by using Review Manager.
RESULTS:
Totally 54 studies were enrolled for analyses. Pooled overall analyses suggested that VDR rs1544410 (dominant model: p = 0.02; allele model: p = 0.04), rs2228570 (recessive model: p = 0.01; allele model: p = 0.03) and rs731236 (recessive model: p = 0.02; allele model: p = 0.02) variants were significantly associated with TB. Further subgroup analyses by ethnicity revealed that rs1544410 variant was significantly associated with TB in South Asians (dominant and allele models) and Caucasians (dominant, recessive and allele models), rs2228570 variant was significantly associated with TB in East Asians (recessive model), and rs731236 variant was significantly associated with TB in South Asians (dominant, recessive and allele models).
CONCLUSIONS: Our meta-analysis suggested that VDR rs1544410, rs2228570 and rs731236 variants might serve as genetic biomarkers of TB in certain populations.