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Thyroid Cancer 1.3X higher risk if low vitamin D (yet again) – meta-analysis June 2018

Vitamin D Deficiency as a Risk Factor for Thyroid Cancer: A Meta-analysis of Case-control studies

Nutrition, online 2 June 2018, https://doi.org/10.1016/j.nut.2018.04.015

PDF is available free at Sci-Hub

Junyu Zhao, PhDa, 1, Haipeng Wang, PhDb, 1, Zhongwen Zhang, PhDa, Xiaojun Zhou, PhDa, Jinming Yao, M.D.a, Rui Zhang, PhDa, Lin Liao, PhDa, , , Jianjun Dong, PhDc, ,

Highlights
• The association between vitamin D deficiency and thyroid cancer is controversial
• The levels of serum 25-hydroxyvitamin D were lower in patients with thyroid cancer preoperative than those of controls
• There is no difference when thyroid cancer patients underwent a thyroidectomy
• Vitamin D deficiency may as a risk factor for thyroid cancer

Objective
The association between vitamin D deficiency and thyroid cancer is controversial. Some reported that higher serum vitamin D level might protect against thyroid cancer. Whereas others did not show the same result, even propose the opposite opinion. To conclude the controversy above, we conducted this meta-analysis of association between vitamin D deficiency and thyroid cancer.

Research Methods & Procedures
Database including PubMed, Cochrane library, Sinomed, CNKI, Wanfang, and clinical trial register centers, for case-control studies of vitamin D in thyroid cancer were searched. Fourteen articles were involved to conduct the meta-analysis.

Results
There were 14 studies included in this meta-analysis. Fixed-effect model was used to merge the standardized mean difference value of serum 25-hydroxyvitamin D level and the pooled effect showed that the levels of serum 25-hydroxyvitamin D were lower in patients with thyroid cancer preoperative than those of controls (-0.22, 95% CI -0.36 to -0.09, P=0.001). But there is no difference when thyroid cancer patients underwent a thyroidectomy (-0.19, 95% CI -0.47 to 0.10, P=0.21). Fixed-effect model was used to pooled the odds ratio of thyroid cancer and vitamin D deficiency and it showed that the pooled odds ratio from six studies was 1.30 (95% CI 1.00 to 1.69, P=0.05). Subgroup analysis of 25-hydroxyvitamin D level between different pathological characteristics in patient with thyroid cancer was summarized, but no statistical difference was concluded.

Conclusions
Lower serum 25-hydroxyvitamin D levels were associated with increased risk of thyroid cancer. Meanwhile, vitamin D deficiency may as a risk factor for thyroid cancer.


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