Vitamin D Deficiency as a Risk Factor for Thyroid Cancer: A Meta-analysis of Case-control studies 2018
Nutrition, online 2 June 2018, https://doi.org/10.1016/j.nut.2018.04.015
- Thyroid Cancer rate has increased 3X in 3 decades, Vitamin D Receptor decreases, Calcium increases – Aug 2017
- 2X more Thyroid Cancer malignancy if less than 15 ng of vitamin D – June 2012
Cancer category starts with the following
247 items Overview Cancer and vitamin D
- After Cancer Diagnosis
- Bladder Cancer
- Breast Cancer
236 items Overview Breast Cancer and Vitamin D
- Colon Cancer
128 items Overview Cancer-Colon and vitamin D
- Liver Cancer
- Lung Cancer
53 items Overview Lung cancer and vitamin D
- Lymphoma Cancer
- Other Cancer
- Ovarian Cancer
- Pancreatic Cancer
- Prostate Cancer
96 items Overview Prostate Cancer and Vitamin D
- Skin Cancer
113 items Overview Suntan, melanoma and vitamin D
- Vitamin D prevents and treats cancer in many ways – May 2021
- Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
- 8 ways that Cancer might be prevented by Vitamin D - June 2019
- Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
- Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Melanoma 25 X more likely if low vitamin D – Feb 2018
- Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018
Cancers get less Vitamin D when there is a poor Vitamin D Receptor
- Vitamin D Receptor pages in VitaminDWiki with CANCER in title 76 as of March 2022
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Vitamin D Receptor and Cancer
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
- Breast Cancer and VDR
- Colon Cancer and VDR
- Prostate Cancer and VDR
- Skin Cancer and VDR
- Note some Health problems, such as some Cancers, protect themselves
by actively reducing Receptor activation
Junyu Zhao, PhDa, 1, Haipeng Wang, PhDb, 1, Zhongwen Zhang, PhDa, Xiaojun Zhou, PhDa, Jinming Yao, M.D.a, Rui Zhang, PhDa, Lin Liao, PhDa, , , Jianjun Dong, PhDc, ,
• The association between vitamin D deficiency and thyroid cancer is controversial
• The levels of serum 25-hydroxyvitamin D were lower in patients with thyroid cancer preoperative than those of controls
• There is no difference when thyroid cancer patients underwent a thyroidectomy
• Vitamin D deficiency may as a risk factor for thyroid cancer
The association between vitamin D deficiency and thyroid cancer is controversial. Some reported that higher serum vitamin D level might protect against thyroid cancer. Whereas others did not show the same result, even propose the opposite opinion. To conclude the controversy above, we conducted this meta-analysis of association between vitamin D deficiency and thyroid cancer.
Research Methods & Procedures
Database including PubMed, Cochrane library, Sinomed, CNKI, Wanfang, and clinical trial register centers, for case-control studies of vitamin D in thyroid cancer were searched. Fourteen articles were involved to conduct the meta-analysis.
There were 14 studies included in this meta-analysis. Fixed-effect model was used to merge the standardized mean difference value of serum 25-hydroxyvitamin D level and the pooled effect showed that the levels of serum 25-hydroxyvitamin D were lower in patients with thyroid cancer preoperative than those of controls (-0.22, 95% CI -0.36 to -0.09, P=0.001). But there is no difference when thyroid cancer patients underwent a thyroidectomy (-0.19, 95% CI -0.47 to 0.10, P=0.21). Fixed-effect model was used to pooled the odds ratio of thyroid cancer and vitamin D deficiency and it showed that the pooled odds ratio from six studies was 1.30 (95% CI 1.00 to 1.69, P=0.05). Subgroup analysis of 25-hydroxyvitamin D level between different pathological characteristics in patient with thyroid cancer was summarized, but no statistical difference was concluded.
Lower serum 25-hydroxyvitamin D levels were associated with increased risk of thyroid cancer. Meanwhile, vitamin D deficiency may as a risk factor for thyroid cancer.
Association between vitamin D deficiency and risk of thyroid cancer: a case-control study and a meta-analysis.
J Endocrinol Invest. 2018 Oct;41(10):1199-1210. doi: 10.1007/s40618-018-0853-9. Epub 2018 Feb 20.
Hu MJ1, Zhang Q1, Liang L1, Wang SY2, Zheng XC2, Zhou MM1, Yang YW1, Zhong Q1, Huang F3.
PURPOSE: Although vitamin D is reportedly associated with various cancers, the association between vitamin D and thyroid cancer is indefinite. We aimed to investigate whether this association applies to thyroid cancer (TC).
METHODS: A total of 276 Chinese Han people were recruited in a current matched case-control study. Multivariable conditional logistic regression was computed to estimate the association between plasma 25(OH)D and papillary thyroid cancer (PTC). In addition, we searched relevant studies in PubMed and Web of Science databases before December 2017 to conduct a meta-analysis.
In our case-control study, plasma 25(OH)D concentration was inversely associated with PTC risk (highest tertile vs lowest tertile: adjusted OR = 0.25; 95% CI 0.10, 0.61; Ptrend = 0.003). This association was independent of body mass index and physical activity (all adjusted Pinteraction > 0.05). A total of 11 studies were included in the meta-analysis, among which ten studies have been published and one was our case-control study. Compared with 25(OH)D non-deficient group, the pooled OR of TC was 1.42 (95% CI 1.17, 1.73) in the deficient group. Similarly, blood 25(OH)D levels in patients with TC were tend to be lower than those in the controls (SMD = - 0.20, 95% CI - 0.36, - 0.03).
CONCLUSIONS: A high level of circulating 25(OH)D was associated with a decreased TC risk. This association has important significance in public health and should, therefore, be further studied.
See in VitaminDWiki at Thyroid Cancer 1.4 X higher risk if low vitamin D– meta-analysis Feb 2018Thyroid Cancer 1.3X higher risk if low vitamin D (yet again) – meta-analysis June 2018
1929 visitors, last modified 10 Jan, 2019,This page is in the following categories (# of items in each category)
- Breast Cancer and VDR
- After Cancer Diagnosis