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Preterm Births decreased by Omega-3 (analysis of 184 countries) – April 2019

Omega-3 polyunsaturated fatty acid intake norms and preterm birth rate: a cross-sectional analysis of 184 countries

BMJ Open http://dx.doi.org/10.1136/bmjopen-2018-027249
Timothy H Ciesielski1,2,3, Jacquelaine Bartlett1,3, Scott M Williams1,3

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Significantly fewer Preterm Births in countries with higher Omega-3 consumption

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Map of Omega-3 consumption by countries

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Background The preponderance of evidence now indicates that elevated long-chain omega-3 polyunsaturated fatty acid (LC omega-3 PUFA) intake is often associated with reduced risk of preterm birth (PTB). This conclusion is based on recent meta-analyses that include several studies that reported null findings. We probed the reasons for this heterogeneity across studies and its implications for PTB prevention using country-level data.

Methods We analysed the relationship between national PTB rates (<37 weeks of gestation) and omega-3 PUFA intake norms from 184 countries for the year 2010. To estimate the total LC omega-3 PUFA levels (eicosapentaenoic acid [EPA]/docosahexaenoic acid [DHA]) that these norms produce we utilised a metric that accounts for

  • (1) seafood-based omega-3 intake (EPA/DHA) and
  • (2) plant-based omega-3 intake (alpha-linolenic acid [ALA]),
    • ~20% of which is converted to EPA/DHA in vivo.

We then assessed the shape of the omega-3–PTB relationship with a penalised spline and conducted linear regression analyses within the linear sections of the relationship.

Results Penalised spline analyses indicated that PTB rates decrease linearly with increasing omega-3 levels up to ~600 mg/day. Income-adjusted linear regression analysis among the countries in this exposure range indicated that the number of PTBs per 100 live births decreases by 1.5 (95% CI 2.8 to 0.3) for each 1 SD increase in omega-3 intake norms (383 mg/day).

Conclusions Taken with prior evidence for a causal association on the individual level, our findings indicate that omega-3 PUFA deficiency may be a widespread contributing factor in PTB risk. Consideration of baseline omega-3 PUFA levels is critical in the design of future interventions.

Created by admin. Last Modification: Wednesday May 1, 2019 16:38:30 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
11831 Omega-3 map.jpg admin 27 Apr, 2019 13:20 37.79 Kb 38
11830 PTB Omegs-3.jpg admin 27 Apr, 2019 13:20 14.42 Kb 42
11829 PTB Omegs-3l.pdf PDF 2019 admin 27 Apr, 2019 13:19 675.39 Kb 18
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