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Depression after pregnancy and vitamin D – Nov 2013

Vitamin D status during pregnancy and the risk of subsequent postpartum depression: a case-control study.

PLoS One. 2013 Nov 27;8(11):e80686. doi: 10.1371/journal.pone.0080686. eCollection 2013.
Nielsen NO1, Strøm M, Boyd HA, Andersen EW, Wohlfahrt J, Lundqvist M, Cohen A, Hougaard DM, Melbye M.

Epidemiological studies have provided evidence of an association between vitamin D insufficiency and depression and other mood disorders, and a role for vitamin D in various brain functions has been suggested. We hypothesized that low vitamin D status during pregnancy might increase the risk of postpartum depression (PPD). The objective of the study was thus to determine whether low vitamin D status during pregnancy was associated with postpartum depression. In a case-control study nested in the Danish National Birth Cohort, we measured late pregnancy serum concentrations of 25[OH]D3 in 605 women with PPD and 875 controls. Odds ratios [OR) for PPD were calculated for six levels of 25[[OH]D3. Overall, we found no association between vitamin D concentrations and risk of PPD (p = 0.08). Compared with women with vitamin D concentrations between 50 and 79 nmol/L, the adjusted odds ratios for PPD were 1.35 (95% CI: 0.64; 2.85), 0.83 (CI: 0.50; 1.39) and 1.13 (CI: 0.84; 1.51) among women with vitamin D concentrations < 15 nmol/L, 15-24 nmol/L and 25-49 nmol/L, respectively, and 1.53 (CI: 1.04; 2.26) and 1.89 (CI: 1.06; 3.37) among women with vitamin D concentrations of 80-99 nmol/L and ≥ 100 nmol/L, respectively. In an additional analysis among women with sufficient vitamin D (≥ 50 nmol/L), we observed a significant positive association between vitamin D concentrations and PPD. Our results did not support an association between low maternal vitamin D concentrations during pregnancy and risk of PPD. Instead, an increased risk of PPD was found among women with the highest vitamin D concentrations.
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PMID: 24312237


Note: The study used the amount of depression medicine taken as a proxy of PPD

"sensitivity of antidepressant use as a proxy for major depression has been evaluated by Thielen et al. [43] to be 50%."

 Download the PDF.

See also VitaminDWiki

Items tagged in both categories Depression AND Pregnancy

Attached files

ID Name Comment Uploaded Size Downloads
4353 postpartum depression Nov 2013.pdf PDF 2013 admin 12 Sep, 2014 13:05 200.64 Kb 601
4352 PPD.jpg admin 12 Sep, 2014 13:05 27.01 Kb 874
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