The role of neonatal vitamin D in the association of prenatal depression with toddlers ADHD symptoms: A birth cohort study
Journal of Affective Disorders 281 (2021) 390-396
Shuang-shuang Maa,b,c,d,1, Dao-min Zhue,1, Wan-jun Yina,b,c,d, Jia-hu Haoa,b,c,d,
Kun Huanga,b，c,d, Fang-biao Taoa,b,c,d, Rui-xue Taof,2,*, Peng Zhua,b,c,d,2,**
- ADHD 3.7 X higher risk if depressed pregnancy (low vitamin D) – Dec 2020
- Depression after childbirth 5 X less likely if good Omega-3 index – April 2019
- Postpartum Depression 3.3 X more likely if low vitamin D – Oct 2018
- Vitamin D prevents pregnancy depression (US Prevention Task Force say it cannot be prevented) - Feb 2019
- Depressed black pregnant women should take vitamin D – April 2018
- Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
- Perinatal depression decreased 40 percent with just a few weeks of 2,000 IU of vitamin D – RCT Aug 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Depression in youths associated with low vitamin D during pregnancy – Oct 2014
- Postpartum depression 7X more likely if less than 10 ng of vitamin D – Sept 2014
- Depression after pregnancy and vitamin D – Nov 2013
- Depression and Vitamin D during Pregnancy – Dissertation Aug 2014
- Depression during pregnancy twice as likely if consume little vitamin D – July 2014
- Antidepressants might increase infertility and pregnancy problems – Nov 2012
- Association between season of birth and suicide – perhaps vitamin D – Sept 2012
- Depression 50 percent more likely if low vitamin D in early pregnancy – Aug 2012
- Pregnant blacks 50 pcnt more likely to be depressed if 3 ng less vitamin D – July 2012
- Depressed mothers more likely to have small babies – Aug 2010
- An Exploratory Study of Postpartum Depression and Vitamin D - May 2010
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- Attention-Deficit Hyperactivity Disorder helped by Vitamin D, need more data – meta-analysis July 2019
- Risk of severe ADHD increased 2X if multiple pesticides in urine while pregnant – June 2019 - Pesticides often reduce Vitamin D by 10 ng
- Increased risk of ADHD (28 pct.) and Autism (58 pct.) if low vitamin D during pregnancy – meta-analysis Jan 2019
ADHD and Vitamin D Deficiency contains the following
- "ADHD 1.5X more likely if low Vitamin D during early pregnancy– Dec 2019"
- "For every 10 ng more vitamin D during pregnancy 11% less likely for child to have ADHD symptoms - July 2015"
Background: Vitamin D has been demonstrated a “neuroprotective” effect, but it is unclear whether early-life adequate vitamin D protect adverse neurodevelopment. We aimed to examine the role of neonatal vitamin D in the association of maternal depression (MD) symptoms with toddlers ADHD.
Methods: Participants included 1 125 mother-infant pairs from the China-Anhui Birth Cohort study. MD was assessed by the Center for Epidemiological Studies Depression Scale (CES-D) at 30-34 gestational weeks. Toddlers ADHD was reported by the Conners’ Hyperactivity Index (CHI) at 48-54 months postpartum. Multiple logistic regression models were performed to evaluate the association of maternal depressive score and toddlers ADHD while cord blood 25(OH)D levels were stratified.
Results: Toddlers of mothers with higher depression score were at higher risk of ADHD (20.1% vs 11.1%, P = 0.003; adjusted RR=1.75, 95% CI: 1.10-2.81). Among toddlers with neonatal vitamin D deficiency (VDD), ADHD risk was significantly increased with maternal MD (adjusted RR=3.74, 95% CI: 1.49-9.41), but the association was not found in toddlers with neonatal vitamin D adequacy (VDA). Compared to toddlers without MD, toddlers with both MD and neonatal VDD had higher risk of ADHD (adjusted RR=3.10, 95% CI: 1.44-6.63). But the risk did not significantly increase in toddlers with MD and neonatal VDA (adjusted RR=1.53, 95% CI: 0.86-2.72). Limitations: Maternal depressive symptoms in early pregnancy and anxious symptoms were needed to include.
Conclusion: This prospective study indicated that the detrimental effect of maternal prenatal depressive symptoms on offspring’ s ADHD symptoms strengthened in toddlers with neonatal VDD.