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Nanoemulsion vitamin D is again found to be the best liquid form (for rats in this case) – June 2019

Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model.

Medicina (Kaunas). 2019 Jun 10;55(6). pii: E265. doi: 10.3390/medicina55060265.
Šimoliūnas E1, Rinkūnaitė I2, Bukelskienė Ž3, Bukelskienė V4.

 Download the PDF from VitaminDWiki


Background and Objectives: The major cause of vitamin D deficiency is inadequate exposure to sunlight. It is difficult to supplement it with food because sufficient concentrations of vitamin D naturally occur only in a handful of food products. Thereby, deficiency of this vitamin is commonly corrected with oral supplements. Different supplement delivery systems for improved vitamin D stability and bioavailability are proposed. In this study, we compared efficiency of three vitamin D delivery systems: microencapsulated, micellized, and oil-based.

Materials and Methods: As a model in this medical testing, laboratory rats were used for the evaluation of bioavailability of different vitamin D vehicles. Animals were divided into three groups: the first one was given microencapsulated vitamin D3, the second-oil-based vitamin D3, and the third-micellized vitamin D3. Test substances were given per os to each animal for 7 days, and vitamin D concentration in a form of 25-hydroxyvitamin D (25(OH)D) in the blood was checked both during the vitamin delivery period and later, up to the 24th day.

Results: Comparison of all three tested products showed that the microencapsulated and oil-based vitamin D3 vehicles were the most bioavailable in comparison to micellized vitamin D3. Even more, the effect of the microencapsulated form of vitamin D3 remained constant for the longest period (up to 14 days).

Conclusions: The results of this study suggest that the oral vitamin D supplement vehicle has an impact on its bioavailability, thus it is important to take into account how much of the suppled vitamin D will be absorbed. To maximize the full exploit of supplement, the best delivery strategy should be employed. In our study, the microencapsulated form of vitamin D was the most bioavailable.

Nanemulsion form has a longer half-life and has 24% more "area under the curve" than oil-based

Note: Vitamin D generated by the Sun/UV has an even longer half-life

VitaminDWiki - Nanoemulsion Vitamin D may be a substantially better form includes:

50,000 IU powder in capsule
Example Biotech Pharmacal
Example micro D3
Average Cost
per day for 10,000 IU
4 cents8 cents
IU per serving 50,000 IU = capsule2,000 IU = drop
Servings if want average
of 10,000 IU/day
1 capsule
per 5 days
25 drops = 1 /4 teaspoon
per 5 days
Shelf life 1 year?6 months?
Add to food/drinkYes (powder) possiblly
Apply to skinNoYes
Swish in mouth
for fast response
Yes if put powder in saliva
or swish vitamin D water
Availability to cell
- better than bio-availability
standardperhaps 2X more
- due to small size
or activation of Vitamin D Receptor

24+ VitaminDWiki pages with NANOEMULSION or EMULSION etc. in the title

This list is automatically updated

Items found: 25
Title Modified
Vitamin D: liposomal and nanoemulsion forms - Chat-GPT Dec 2023 30 Dec, 2023
Nanoemulsion Vitamin D is faster and better - many studies 06 Oct, 2023
Fast responses to Vitamin D – loading dose, nanoemulsion and Calcifediol – April 2023 15 Apr, 2023
Nanoemulsion Vitamin D faster and better (paywall) – RCT Dec 2021 02 Dec, 2021
COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT Nov 12, 2020 21 Sep, 2021
COVID-19 outpatients getting Quercetin nanoemulsion had excellent outcomes (Q increased Vitamin D in cells) – RCT – June 2021 30 Jul, 2021
Nanoemulsion Vitamin D may be a substantially better form 02 Jun, 2021
COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021 22 May, 2021
Hydrogel encapsulated vitamin D gets to colon – Sept 2018 25 Feb, 2021
Inhaling Vitamin D nanoemulsion through nose gets lots more to the brain (mice) – July 2020 03 Aug, 2020
Vitamin D encapsulated in gum arabic 4X more bioavailable (in rat test)- July 2020 22 Jul, 2020
Vitamin D nanoemulsion, with comments on COVID-19 – June 2, 2020 04 Jun, 2020
Nanoemulsion vitamin D is again found to be the best liquid form (for rats in this case) – June 2019 20 Dec, 2019
Bioavailability of nanoemulsion formulations of Vitamin D3 – Nov 2019 20 Dec, 2019
Treat wounds, stop inflammation with nanoemulsion textile of Omega-3 and Resveratrol - Sept 2019 15 Aug, 2019
Vitamin D nanoemulsion etc. for fortification, pills, injections, topical and cancer – July 2019 18 Jul, 2019
Vitamin D Emulsion update - March 2019 28 Mar, 2019
Vitamin D Emulsions - nano 2X better than coarse – Dec 2017 04 Mar, 2019
Vitamin D nanoemulsion corrected deficiency and improved bones in 1 week (high dose in rats) – Jan 2019 05 Jan, 2019
Advances in Vitamin D emulsions, nanoparticles, etc. – Jan 2019 30 Dec, 2018
Colitis treated by activated vitamin D getting into the colon via emulsion (mice) – July 2018 24 Jul, 2018
Lung cancer and inhaled emulsions (wonder about inhaled Vitamin D) – 2018 17 Jun, 2018
Inhaled nanoemulsion of Vitamin D killed lung bacteria – Sept 2017 19 Apr, 2018
Nano-encapsulated of Vitamin D3, Calcidiol, calcitriol look promising, esp time release – Dec 2012 03 Oct, 2015
Nanoemulsions of vitamin D help reduce asthma markers in mice– Dec 2013 12 Dec, 2013

Created by admin. Last Modification: Saturday September 23, 2023 22:32:48 GMT-0000 by admin. (Version 16)

Attached files

ID Name Comment Uploaded Size Downloads
13201 Response.jpg admin 20 Dec, 2019 55.04 Kb 1310
13199 AUC.jpg admin 20 Dec, 2019 54.56 Kb 1310
13197 Feeding.jpg admin 20 Dec, 2019 24.75 Kb 1285
13196 Forms of D - rats.pdf admin 20 Dec, 2019 873.76 Kb 517