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Nanoemulsion vitamin D is again found to be the best liquid form (for rats in this case) – June 2019

Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model.

Medicina (Kaunas). 2019 Jun 10;55(6). pii: E265. doi: 10.3390/medicina55060265.
Šimoliūnas E1, Rinkūnaitė I2, Bukelskienė Ž3, Bukelskienė V4.

VitaminDWiki

Nanemulsion form has a longer half-life and has 24% more "area under the curve" than oil-based
Note: Vitamin D generated by the Sun/UV has an even longer half-life

Biotech Pharmacal
50,000 IU
Micro D3
Nanoemulsion
Average Cost
per day for 10,000 IU
4 cents8 cents
IU per serving 50,000 IU = capsule2,000 IU = drop
Servings if want
10,000 IU avg. per day
1 capsule
per 5 days
25 drops = 1 /4 teaspoon
per 5 days
Shelf life 1 year?6 months?
Form gel-cap/powderLiquid
Add to food/drinkYespossiblly
Apply to skinNoperhaps
Gut-friendlyperhapsprobably
Ingredients might cause
allergic reaction in small % of people
No reactionperhaps
Availability to cell
- better than bio-availability
standardperhaps 2X more
- due to small size
or activation of Vitamin D Receptor

 Download the PDF from VitaminDWiki
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Background and Objectives: The major cause of vitamin D deficiency is inadequate exposure to sunlight. It is difficult to supplement it with food because sufficient concentrations of vitamin D naturally occur only in a handful of food products. Thereby, deficiency of this vitamin is commonly corrected with oral supplements. Different supplement delivery systems for improved vitamin D stability and bioavailability are proposed. In this study, we compared efficiency of three vitamin D delivery systems: microencapsulated, micellized, and oil-based.

Materials and Methods: As a model in this medical testing, laboratory rats were used for the evaluation of bioavailability of different vitamin D vehicles. Animals were divided into three groups: the first one was given microencapsulated vitamin D3, the second-oil-based vitamin D3, and the third-micellized vitamin D3. Test substances were given per os to each animal for 7 days, and vitamin D concentration in a form of 25-hydroxyvitamin D (25(OH)D) in the blood was checked both during the vitamin delivery period and later, up to the 24th day.

Results: Comparison of all three tested products showed that the microencapsulated and oil-based vitamin D3 vehicles were the most bioavailable in comparison to micellized vitamin D3. Even more, the effect of the microencapsulated form of vitamin D3 remained constant for the longest period (up to 14 days).

Conclusions: The results of this study suggest that the oral vitamin D supplement vehicle has an impact on its bioavailability, thus it is important to take into account how much of the suppled vitamin D will be absorbed. To maximize the full exploit of supplement, the best delivery strategy should be employed. In our study, the microencapsulated form of vitamin D was the most bioavailable.

Some of the non-gene restrictions to utilizing Vitamin D

Non-gene Restrictions VDW11479


Created by admin. Last Modification: Wednesday July 22, 2020 11:25:15 GMT-0000 by admin. (Version 13)

Attached files

ID Name Comment Uploaded Size Downloads
13201 Response.jpg admin 20 Dec, 2019 14:59 55.04 Kb 176
13199 AUC.jpg admin 20 Dec, 2019 14:02 54.56 Kb 170
13197 Feeding.jpg admin 20 Dec, 2019 14:01 24.75 Kb 173
13196 Forms of D - rats.pdf PDF 2019 admin 20 Dec, 2019 14:01 873.76 Kb 88
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