Toggle Health Problems and D

Bone marrow transplant – like other traumas – lowers vitamin D levels – July 2011

Decreased bone mineral density in young adults treated with SCT in childhood: the role of 25-hydroxyvitamin D.

Bone Marrow Transplant. 2011 Jul 18. doi: 10.1038/bmt.2011.147.
Frisk P, Arvidson J, Ljunggren O, Gustafsson J.
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

We measured bone mineral density (BMD) with dual-energy X-ray absorptiometry in the total body, at the lumbar spine, at the femoral neck and in the total hip, in 18 young adults with a median of 18.2 years after SCT. Fifteen patients had undergone auto-SCT and all patients had received TBI. The patients had significantly lower BMD in the total body, at the femoral neck, and in the total hip compared with age- and sex-matched controls.

  • Six of 18 patients (33%) had low bone mass (z-score <-1) at one or more measurement sites,
  • as opposed to two of the controls (11%, P=0.29).

We found no significant influence of growth hormone levels or of untreated hypogonadism on BMD variables. Levels of 25-hydroxy OH vitamin D were lower among the patients (35.2 vs 48.8?nmol/L, P=0.044) and were significantly correlated with total body BMD in the patient group (r=0.55, P=0.021).

All six patients with low bone mass had hypovitaminosis D (< 37?nmol/L as opposed to 4 of the 11 (36%) patients without low bone mass (P=0.035).

In conclusion, we found decreased BMD in SCT survivors, which may in part be caused by 25(OH) vitamin D deficiency.

PMID: 21765478

See also VitaminDWiki

Trauma and surgery contains the following

Trauma and Surgery category has 308 articles

see also Concussions
Overview Fractures and Falls and Vitamin D
Cancer - After diagnosis   chemotherapy
TBI OR "Traumatic Brain Injury - 21 in title as of Sept 2022
Search VitaminDWiki for cathelecidin OR hCAP18 219 items as of March 2020
Search VitaminDWiki for ICU OR “critical care” OR “intensive care” OR “acute care”
   1740 items as of May 2019

Search VitaminDWiki for transplant 794 items as of Jan 2018
Trauma and Surgery is associated with 22 other VitaminDWiki categories
  Such as loading dose 33, Mortality 23, Infant-Child 21 Intervention 19 Cardiovascular 13, Injection 13 in Sept 2022

See any problem with this page? Report it (WORKS NOV 2021)