Decreased bone mineral density in young adults treated with SCT in childhood: the role of 25-hydroxyvitamin D.

Bone Marrow Transplant. 2011 Jul 18. doi: 10.1038/bmt.2011.147.
Frisk P, Arvidson J, Ljunggren O, Gustafsson J.
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

We measured bone mineral density (BMD) with dual-energy X-ray absorptiometry in the total body, at the lumbar spine, at the femoral neck and in the total hip, in 18 young adults with a median of 18.2 years after SCT. Fifteen patients had undergone auto-SCT and all patients had received TBI. The patients had significantly lower BMD in the total body, at the femoral neck, and in the total hip compared with age- and sex-matched controls.

• Six of 18 patients (33%) had low bone mass (z-score <-1) at one or more measurement sites,
• as opposed to two of the controls (11%, P=0.29).

We found no significant influence of growth hormone levels or of untreated hypogonadism on BMD variables. Levels of 25-hydroxy OH vitamin D were lower among the patients (35.2 vs 48.8?nmol/L, P=0.044) and were significantly correlated with total body BMD in the patient group (r=0.55, P=0.021).

All six patients with low bone mass had hypovitaminosis D (< 37?nmol/L as opposed to 4 of the 11 (36%) patients without low bone mass (P=0.035).

In conclusion, we found decreased BMD in SCT survivors, which may in part be caused by 25(OH) vitamin D deficiency.

PMID: 21765478

---

See also VitaminDWiki

• 200 IU vitamin D per kg is not enough for some health problems (example– bone marrow stem cell) – July 2016

Trauma and surgery contains the following

Trauma and Surgery category has 256 articles

see also Concussions
Overview Fractures and Falls and Vitamin D
Cancer - After diagnosis   chemotherapy
Search VitaminDWiki for TBI OR "Traumatic Brain Injury" 690 items as of May 2019
Search VitaminDWiki for cathelecidin OR hCAP18 187 items as of May 2019
Search VitaminDWiki for ICU OR “critical care” OR “intensive care” OR “acute care”
   1740 items as of May 2019
Search VitaminDWiki for transplant 794 items as of Jan 2018