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Liver transplants in children more likely to be rejected if insufficient vitamin D – Aug 2021

Vitamin D Insufficiency Prior to Paediatric Liver Transplantation Is Associated with Early T-Cell Mediated Rejection

Children (Basel). 2021 Jul 20;8(7):612. doi: 10.3390/children8070612.
Nathalie M Rock 1, Elisa Anghileri 1 2, Vladimir L Cousin 1 3, Laetitia-Marie Petit 1, Valérie A McLin 1


Objectives: T-cell mediated rejection (TCMR) can compromise long-term liver allograft survival. The immunomodulatory properties of vitamin D are increasingly recognized. We investigated whether perturbations in vitamin D metabolism prior to LT may predispose to TCMR in a representative cohort of paediatric LT recipients.

Methods: In this retrospective single-center study of children who underwent liver transplantation between 2005 and 2017, we collected serum 25(OH) vitamin D levels and other parameters related to vitamin D metabolism. Post-transplant variables were collected from medical records during the first year following LT.

Results: Eighty-two patients were included. Twenty-six (32%) developed TCMR, 52 (65%) presented at least one event of 25(OH) D insufficiency during the year before the transplant, while 23 (32%) had at least one documented elevated plasma parathyroid hormone level. Forty-six patients benefited from nutritional support (56%). The development of TCMR was associated with vitamin D insufficiency pre-LT (p = 0.01). No significant correlations were identified between PTH levels and incidence of TCMR. The association was stronger in patients transplanted for cholestatic diseases (p = 0.004).

Conclusions: Vitamin D insufficiency before a liver transplant may be associated with TCMR during the first year post-LT. These findings warrant further investigation.
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VitaminDWiki pages containing TRANSPLANT in title (32 as of April 2022)

Items found: 36
Title Modified
Autism risky if low vitamin D during pregnancy and early life (mice, fecal transplant reversed it) – March 2024 27 Mar, 2024
Vitamin D helps organ transplant - many studies 30 Nov, 2023
Liver transplant failure 2.7X more-likely if low vitamin D - Nov 2023 30 Nov, 2023
Vitamin D 100,000 IU loading dose and stem cell transplants – RCT Oct 2023 31 Oct, 2023
Fecal transplants - many studies 26 Apr, 2023
Fracture 4X less likely following kidney transplant if high-dose Vitamin D (100,000 every 2 weeks) – RCT Jan 2023 25 Jan, 2023
Fecal transplant from young reduced age-associated defects in old (mice so far) – Aug 2021 27 Aug, 2021
Liver transplants in children more likely to be rejected if insufficient vitamin D – Aug 2021 07 Aug, 2021
Very low Vitamin D levels after Liver transplant in children (need Calcitriol or topical) – May 2021 03 Jun, 2021
Kidney transplant rejection 1.8X more likely if low vitamin D – May 2021 22 May, 2021
1,000 IU of vitamin D provides little benefit (Kidney transplant in this case) – April 2021 22 Apr, 2021
Organ Transplant patients probably need more UV and or vitamin D April 2010 24 Mar, 2021
If you are getting a lung transplant you must have vitamin D - April 2012 24 Mar, 2021
Omega-3 reduced pancreas transplant failure by 3X and sepsis by 2X – review Dec 2019 18 Dec, 2019
Stem cell transplant (HSCT) patients are dying due to lack of vitamin D – Oct 2019 28 Oct, 2019
Stem Cell Transplants consume vitamin D – July 2011 23 Oct, 2019
Stem cell transplant (HSCT). death 28 percent less likely for each 10ng higher vitamin D level – Oct 2019 23 Oct, 2019
Fecal transplants could prevent 12,000 C.difficile deaths a year, but one person died, so lets wait – July 2019 01 Aug, 2019
4X reduction in bone fractures following Kidney Transplant with monthly Vitamin D (100,000 IU) - RCT June 2019 17 Jun, 2019
Fecal transplants increased Vitamin D levels (germ-free mice) – March 2018 29 Jun, 2018
Liver transplant needs Vitamin D (actually semi-activated, not regular) – May 2017 27 May, 2017
Bone marrow transplant – like other traumas – lowers vitamin D levels – July 2011 17 Apr, 2017
Vitamin D may help after organ transplant – if can give enough – Jan 2011 25 Mar, 2017
4X fewer malignancies after kidney transplant if got active vitamin D – Prospective Score Sept 2012 25 Mar, 2017
Kidney transplant patients advised to avoid the sun, then 90% have very low vitamin D levels – Sept 2012 25 Mar, 2017
Vitamin D and biophospates are needed after organ transplant – Aug 2011 25 Mar, 2017
Calcitriol (active Vitamin D) recommended after kidney transplant – March 2014 28 Apr, 2016
Active form of vitamin D (calcitriol) cut in half the fractures following organ transplant – meta-analysis Aug 2011 26 Jul, 2015
Gut, Alzheimer, autism, disease, fecal transplant, etc - Dr. Perlmutter, May 2015 18 May, 2015
400,000 IU barely raised liver transplant candidate vitamin D levels (no surprise) – March 2015 26 Mar, 2015
Even with vitamin D supplementation Kidney transplant patients were deficient – Jan 2011 28 Aug, 2012
Babies Receive Heart Transplants Instead of Vitamin D Treatment 25 Jun, 2012
Kidney transplant worked better if initially have high level of vitamin D – April 2012 28 Apr, 2012
Vitamin D levels low both before and after organ transplant July 2011 27 Apr, 2012
Heart transplant 19 ng vitamin D vs liver transplant 13 ng – April 2009 12 Nov, 2011
Many Organ transplants cause skin cancer – what is the role of UV – Feb 2012 No value for 'modification_date_major'

VitaminDWiki - Overview Liver and vitamin D contains

  • Fact: A properly functioning liver is needed for the efficient activation of vitamin D in the body
  • Fact: Liver diseases often result in lower levels of vitamin D
  • Fact: Various pain relievers damage the liver function
  • Fact: Lower levels of vitamin D result in osteoporosis and many other diseases
  • Options with a poorly functioning liver appear to be:
  1. Increased vitamin D (example: 2X more vitamin D if Liver is 1/2 as efficient)
  2. Increase the response you get from vitamin D
  3. Increase sunshine / UVB,
  4. Get the response you get from the sun/UVB
  5. Consider supplementing with Iron - a patented Iron supplement appears to work very well
  6. Get prescription for active form of vitamin D (Calcitriol) which does not need the liver or kidney to get the benefits of vitamin D in the body
  7. Get Calcidiol which does not need the liver
  8. Use Topical Vitamin D - activation by the skin etc does not require the liver

Click on image for ways of getting vitamin D even if Liver is not functioning well

Created by admin. Last Modification: Sunday April 24, 2022 15:23:25 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
16047 Liver transplant reject.jpg admin 07 Aug, 2021 23.90 Kb 208
16046 Liver transplant.pdf admin 07 Aug, 2021 670.63 Kb 237