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Less weight gain if add Vitamin D, even if have a high fat diet (in rats) – RCT Dec 2017

The effects of vitamin D administration on brain inflammatory markers in high fat diet induced obese rats

Mahdieh Abbasalizad Farhangi, Mehran Mesgari-Abbasi, Ghazaleh Nameni, Ghazaleh Hajiluian and Parviz Shahabi
BMC NeuroscienceBMC series – 201718:81, https://doi.org/10.1186/s12868-017-0400-1© The


This study echos many previous studies with humans - less weight gain and even lose weight with vitamin D

Overview Obesity and Vitamin D contains the following summary

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Rats gained less weight if take Vitamin D (independant of amount of fat in diet)


Obesity induced brain inflammation is associated with cognitive disorders. We aimed to investigate the influence of vitamin D on hypothalamus and hippocampus inflammatory response in high-fat diet induced obese rats.

In the beginning of the study, 40 rats were divided into two groups: control diet and high fat diet (HFD) for 16 weeks; then each group subdivided into two groups including: N, ND + vitamin D, HFD and HFD + vitamin D. Vitamin D supplementation was done for 5 weeks at 500 IU/kg dosage. IL-6, IL-1β, NF-Kβ and acetylcholine (ACH) and brain derived neurotropic factor (BDNF) concentrations in hippocampus and hypothalamus homogenate samples were measured by commercial ELISA kits.

Vitamin D administration, reduced food intake and weight gain in studied groups (P < 0.001). Vitamin D reduced hippocampus acetylcholine concentrations in ND + vitamin D group (P < 0.001). High fat diet increased hippocampus IL-6 concentrations significantly (P < 0.05) compared with normal diet receiving groups. Vitamin D could not have significant effects on IL-6 concentrations. Vitamin D administrations reduced IL-1β, NF-Kβ and acetylcholine concentration and BDNF concentrations in ND + vitamin D compared with ND group. These reductions were not significant in HFD + vitamin D versus HFD group.

According to our results, vitamin D reduced food intake and weight gain and modulated the HFD induced inflammatory response in hippocampus and hypothalamus of high fat diet induced obesity. Therefore, this neurosteroid, can be suggested as a supplemental therapeutic tool in prevention of obesity related cognitive and neurodegenerative problems.

Created by admin. Last Modification: Tuesday July 17, 2018 14:20:34 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
9102 Weight gain.jpg admin 02 Jan, 2018 23.65 Kb 678
9100 High fat diet.pdf admin 02 Jan, 2018 897.63 Kb 951