Vitamin D and colon cancer
World J Gastrointest Oncol 2014 November 15; 6(11): 430-437, doi: 10.4251/wjgo.v6.i11.430.
Lidija Klampfer klampfer at southernresearch.org
Southern Research Institute, Birmingham, AL 35205, United States
- Inflammatory bowel diseases treated with vitamin D – Review May 2014
- Overview Cancer-Colon and vitamin D has the following chart
The TOP articles are here:
- Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021
- Colorectal cancer treated by Vitamin D – 19th meta-analysis – Sept 2020
- Many Ashkenazi Jewish diseases associated with low vitamin D or poor Vit D genes
- Molecular Link between Vitamin D and Cancer Prevention – Oct 2013
- After 30 years it still appears that vitamin D deals with colorectal cancer – Oct 2012
The Meta-analysis of many studies of COLON Cancer and Vitamin D are listed here:
- 16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023
- Colorectal Cancer 10 percent more likely if poor Vitamin D Receptor – meta-analysis Jan 2023
- Colorectal cancer 14 percent less likely if 10 ng more Vitamin D – 22nd meta-analysis – Sept 2022
- Colorectal cancer 40 percent less likely if 1000 IU more Vitamin D – 21st meta-analysis – Oct 2021
- Colorectal cancer 25 percent less likely if good level of Vitamin D – 20th meta-analysis – June 2021
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Colorectal cancer treated by Vitamin D – 19th meta-analysis – Sept 2020
- Colon cancer both prevented and treated by Vitamin D – meta-analysis Dec 2019
- Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018
- Colorectal cancer 60 percent less likely: high vs low Vitamin D level – meta-analysis Dec 2016
- Colorectal Cancer recurrence not prevented by 1,000 IU of vitamin D – meta-analysis Dec 2016
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Colon cancer 30 percent more likely if low vitamin D – 12th meta-analysis Aug 2015
- Colon cancer risk reduced by many vitamins – 13 percent reduction by Vitamin D – meta-analysis Jan 2015
- Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis July 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014
- 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012
- Meta-graphs of vitamin D and Cancer – Dec 2011
- Colon cancer probability increases with decreased vitamin D – Meta-analysis July 2011
- Non-cancer colon growths 7 percent less likely with each 10 ng increase in vitamin D – Oct 2011
- Colorectal cancer 26 percent less likely for every 10 ng of vitamin D – meta-analysis Aug 2011
- Colon polyps reduced 15 percent by increasing vitamin D by 20 ng – meta-analysis June 2011
- Meta-analysis of 3 cancers - 10 ng more vitamin D decrease colorectal by 15 percent– May 2010
- Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010
Download the PDF from VitaminDWiki.
Sections in PDF include
VITAMIN D AND COLON CANCER
INHIBITION OF WNT SIGNALING BY VITAMIN D
ANTI-INFLAMMATORY PROPERTIES OF VITAMIN D
A portion of Figure 1
Calcitriol, 1α, 25-dihydroxyvitamin D3 (1,25 (OH)2D3), the most active form of vitamin D, is a pleotropic hormone with a wide range of biological activities. Due to its ability to regulate calcium and phosphate metabolism, 1,25D3 plays a major role in bone health. In addition, 1,25D3 binds to the vitamin D receptor and thereby regulates the expression of a number of genes which control growth, differentiation and survival of cancer cells. In agreement, the levels of vitamin D3 appear to be an essential determinant for the development and progression of colon cancer and supplementation with vitamin D3 is effective in suppressing intestinal tumorigenesis in animal models. Vitamin D3 has been estimated to lower the incidence of colorectal cancer by 50%, which is consistent with the inverse correlation between dietary vitamin D3 intake or sunlight exposure and human colorectal cancer. Several studies confirmed that increasing vitamin D3 lowers colon cancer incidence, reduces polyp recurrence, and that sufficient levels of vitamin D3 are associated with better overall survival of colon cancer patients. Vitamin D regulates the homeostasis of intestinal epithelium by modulating the oncogenic Wnt signaling pathway and by inhibiting tumor-promoting inflammation. Both activities contribute to the ability of 1,25D3 to prevent the development and progression of colon cancer.
Core tip:
Epidemiological studies suggest that deficiency of vitamin D increases the incidence of colon cancer and also has a negative impact on the survival of colon cancer patients. The ability of 1,25D3 to interfere with Wnt signaling and to ameliorate inflammation is likely to contribute to its anticancer activity.
CONCLUSION - from PDF
Calcitriol, the most active form of vitamin D3, acts as a potent steroid hormone that binds to VDR and thereby alters the expression of a variety of genes that regulate growth, differentiation and survival of epithelial cells. Epidemiological studies suggest that deficiency of vitamin D increases the incidence of colon cancer and also has a negative impact on the survival of colon cancer patients. The ability of 1,25D3 to interfere with Wnt signaling and to ameliorate inflammation is likely to contribute to its anticancer activity. The optimal form and adequate concentration of vitamin D that have cancer preventive activity should be established, and randomized clinical trials are needed to confirm that 1,25D3 alone, or in combination with other cytotoxic agents, offers therapeutic benefits.