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Colon cancer – how vitamin D prevents and treats it – Nov 2014

Vitamin D and colon cancer

World J Gastrointest Oncol 2014 November 15; 6(11): 430-437, doi: 10.4251/wjgo.v6.i11.430.
Lidija Klampfer klampfer at southernresearch.org
Southern Research Institute, Birmingham, AL 35205, United States

VitaminDWiki pages on Colon Cancer

see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=64
Overview of ColonCancer and vitamin D

The TOP articles are here:


The Meta-analysis of many studies of COLON Cancer and Vitamin D are listed here:

 Download the PDF from VitaminDWiki.

Sections in PDF include
VITAMIN D AND COLON CANCER
INHIBITION OF WNT SIGNALING BY VITAMIN D
ANTI-INFLAMMATORY PROPERTIES OF VITAMIN D

A portion of Figure 1

Image

Calcitriol, 1α, 25-dihydroxyvitamin D3 (1,25 (OH)2D3), the most active form of vitamin D, is a pleotropic hormone with a wide range of biological activities. Due to its ability to regulate calcium and phosphate metabolism, 1,25D3 plays a major role in bone health. In addition, 1,25D3 binds to the vitamin D receptor and thereby regulates the expression of a number of genes which control growth, differentiation and survival of cancer cells. In agreement, the levels of vitamin D3 appear to be an essential determinant for the development and progression of colon cancer and supplementation with vitamin D3 is effective in suppressing intestinal tumorigenesis in animal models. Vitamin D3 has been estimated to lower the incidence of colorectal cancer by 50%, which is consistent with the inverse correlation between dietary vitamin D3 intake or sunlight exposure and human colorectal cancer. Several studies confirmed that increasing vitamin D3 lowers colon cancer incidence, reduces polyp recurrence, and that sufficient levels of vitamin D3 are associated with better overall survival of colon cancer patients. Vitamin D regulates the homeostasis of intestinal epithelium by modulating the oncogenic Wnt signaling pathway and by inhibiting tumor-promoting inflammation. Both activities contribute to the ability of 1,25D3 to prevent the development and progression of colon cancer.

Core tip:

Epidemiological studies suggest that deficiency of vitamin D increases the incidence of colon cancer and also has a negative impact on the survival of colon cancer patients. The ability of 1,25D3 to interfere with Wnt signaling and to ameliorate inflammation is likely to contribute to its anticancer activity.

CONCLUSION - from PDF

Calcitriol, the most active form of vitamin D3, acts as a potent steroid hormone that binds to VDR and thereby alters the expression of a variety of genes that regulate growth, differentiation and survival of epithelial cells. Epidemiological studies suggest that deficiency of vitamin D increases the incidence of colon cancer and also has a negative impact on the survival of colon cancer patients. The ability of 1,25D3 to interfere with Wnt signaling and to ameliorate inflammation is likely to contribute to its anticancer activity. The optimal form and adequate concentration of vitamin D that have cancer preventive activity should be established, and randomized clinical trials are needed to confirm that 1,25D3 alone, or in combination with other cytotoxic agents, offers therapeutic benefits.

Attached files

ID Name Comment Uploaded Size Downloads
4593 Colon F1.jpg admin 19 Nov, 2014 11:45 21.12 Kb 962
4592 Colon cancer.pdf PDF 2014 admin 19 Nov, 2014 11:36 897.48 Kb 526
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