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Molecular Link between Vitamin D and Cancer Prevention – Oct 2013

Nutrients 2013, 5(10), 3993-4021; doi:10.3390/nu5103993
Meis Moukayed 1email and William B. Grant 2,* email
1 School of Arts and Sciences, American University in Dubai, P. O. Box 28282, Dubai, UAE
2 Sunlight, Nutrition, and Health Research Center, San Francisco, CA 94164-1603, USA
* Author to whom correspondence should be addressed.
Received: 7 August 2013; in revised form: 11 September 2013 / Accepted: 18 September 2013 / Published: 30 September 2013
(This article belongs to the Special Issue Vitamin D and Human Health)

Abstract: The metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (also known as calcitriol), is a biologically active molecule required to maintain the physiological functions of several target tissues in the human body from conception to adulthood. Its molecular mode of action ranges from immediate nongenomic responses to longer term mechanisms that exert persistent genomic effects. The genomic mechanisms of vitamin D action rely on cross talk between 1α,25-dihydroxyvitamin D3 signaling pathways and that of other growth factors or hormones that collectively regulate cell proliferation, differentiation and cell survival. In vitro and in vivo studies demonstrate a role for vitamin D (calcitriol) in modulating cellular growth and development. Vitamin D (calcitriol) acts as an antiproliferative agent in many tissues and significantly slows malignant cellular growth. Moreover, epidemiological studies have suggested that ultraviolet-B exposure can help reduce cancer risk and prevalence, indicating a potential role for vitamin D as a feasible agent to prevent cancer incidence and recurrence. With the preventive potential of this biologically active agent, we suggest that countries where cancer is on the rise—yet where sunlight and, hence, vitamin D may be easily acquired—adopt awareness, education and implementation strategies to increase supplementation with vitamin D in all age groups as a preventive measure to reduce cancer risk and prevalence.


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3067 Cancer Grant 913 T2.jpg admin 02 Oct, 2013 139.28 Kb 2465
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3064 Vitamin D and Cancer prevention.pdf admin 02 Oct, 2013 312.71 Kb 1207