Topical applications of vitamin D on implant surface for bone-to-implant contact enhance: a pilot study in dogs part II.
Clin Oral Implants Res. 2015 Sep 30. doi: 10.1111/clr.12707
Salomó-Coll O1, Maté-Sánchez de Val JE2, Ramírez-Fernandez MP2, Hernández-Alfaro F1, Gargallo-Albiol J1, Calvo-Guirado JL2.
1Department of Oral and Maxillofacial Surgery, International University of Catalonia, Barcelona, Spain.
2International Dentistry Research Cathedra, Universidad Católica San Antonio de Murcia (UCAM), Murcia, Spain.
The aim of this study was to evaluate the effect of topical application of vitamin D over implant surface, placed immediately to the extraction, throughout histological and histomorphometric analysis of peri-implant tissue.
MATERIAL AND METHODS:
Six American foxhound dogs were used in the study. Mandibular premolar distal roots were extracted. Twenty-four immediate conical C1 implants (MIS, Barlev, Israel) were randomly assigned to the distal site on each site of the mandible in three groups: (Group CI) 12 titanium implants alone; (Test Group DI) 12 titanium implants supplemented with vitamin D. Prior to implanting, test implants (DI) were submerged in vitamin D 10% solution. No treatment was applied at control implants (CI). After 12 weeks, animals were sacrificed. Block sections were obtained and processed for mineralized ground sectioning. Bone-to-implant contact (Total BIC and BIC%), new bone formation (NBF), interthread bone (ITB), and histological linear measurements (HLM) were analyzed.
At 12 weeks, all implants were clinically stable and histologically osseointegrated. BIC evaluation showed Total BIC mean and SD values for DI (48.96 ± 2.14), CI (44.56 ± 1.75) (P < 0.05), BIC% DI (43.59 ± 0.98), and CI (42.67 ± 9.26) (P > 0.05). For interthread bone formation, values were as follows: DI (15.21 ± 3.87), CI (14.79 ± 1.45) (P > 0.05), no statistically differences. Regarding peri-implant new bone formation, no statistically differences could be found between the two groups DI (31.87 ± 1.23), CI (27.18 ± 2.38) (P > 0.05). For linear measurements, test group (DI) showed statistically significant less buccal crestal bone loss (CBL) DI (0.37 ± 0.12)*, CI (1.26 ± 0.8) (P < 0.05), and vitamin D implants showed less lingual junctional epithelium DI (1.58 ± 0.43)*, CI (2.18 ± 0.48) (P < 0.05). No differences were observed in the buccal mucosa.
With the limitation of animal studies, topical application of vitamin D on dental implants could reduce crestal bone loss and increase 10% more bone-to-implant contact at 12-week follow-up period.
Download the PDF from Sci-Hub via VitaminDWiki
Wonder if topical Vitamin D would help other human bone surgery as well - teeth, knee, hip, etc?
- Bone implants aided by Vitamin D in 80 percent of studies, conclusion – more studies needed – Feb 2016
- More dental implant bone growth if high vitamin D (natural or supplement) – RCT Feb 2021
Study was cited by 28 studies as of Jan 2022
Did not notice any others using topical vitamin D
VitaminDWiki - DENTAL IMPLANT* in title
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