Low Vitamin D in Narcolepsy with Cataplexy
Bertrand Carlander1, Anne Marie Puech-Cathala2, Isabelle Jaussent3, Sabine Scholz1, Sophie Bayard1,3, Valérie Cochen1, Yves Dauvilliers1,3*
1 National Reference Network for Narcolepsy, Department of Neurology, Hôpital Gui-de-Chauliac, CHU Montpellier, Montpellier, France, 2 Laboratoire d'Hormonologie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France, 3 Inserm U1061, University of Montpellier 1, Montpellier, France
Background
Narcolepsy with cataplexy (NC) is currently thought to be an autoimmune-mediated disorder in which environmental risk factors make a significant contribution to its development. It was proposed that vitamin D deficiency plays a role in autoimmune diseases. Here we investigated whether NC can be associated with 25-hydroxyvitamin D (25(OH)D) level deficiency in patients with NC compared with gender- and age-matched normal controls.
Methodology
Serum level of 25 (OH)D was determined in 51 European patients with typical NC compared to 55 age-, gender-, and ethnicity-matched healthy controls. Demographic and clinical data (age at onset, duration and severity of disease at baseline, and treatment intake at time of study) and season of blood sampling were collected to control for confounding variables.
Principal Findings
Serum 25(OH)D concentration was lower in NC compared to controls (median, 59.45 nmol/l [extreme values 24.05–124.03] vs. 74.73 nmol/l [26.88–167.48] p = 0.0039).
Patients with NC had significantly greater vitamin D deficiency (<75 nmol/l) than controls (72.5% vs 50.9%, p = 0.0238). Division into quartiles of the whole sample revealed that the risk of being affected with NC increased with lower 25(OH)D level, with a 5.34 OR [1.65–17.27] for the lowest quartile (p = 0.0051). Further adjustment for BMI did not modify the strength of the association (OR: 3.63, 95% CI = 1.06–12.46, p = 0.0191). No between BMI and 25(OH)D interaction, and no correlation between 25(OH)D level and disease duration or severity or treatment intake were found in NC.
Conclusion
We found a higher frequency of vitamin D deficiency in NC. Further studies are needed to assess the contribution of hypovitaminosis D to the risk of developing narcolepsy, and to focus on the utility of assessing vitamin D status to correct potential deficiency.
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See also VitaminDWiki
- Vitamin D supplementation eliminated nappiness and pain for one woman – Jan 2011
- Sleep Apnea and vitamin D - Jan 2011 Apnea is a sleep problem, but perhaps has the same cause
- Sleep Apnea patients – 98 percent had low vitamin D – Feb 2016
- Sleep disorders cured by 60-80 ng of vitamin D and some B vitamins – March 2013
Sleep category starts with
A few items in SLEEP category
- Sleep greatly improved by 50,000 IU of vitamin D once every two weeks – RCT Sept 2018
- Sleep disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT May 2017
- Sleep, Dr. Gominak and Vitamin D - several studies
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- On the job sleepiness 2.2X more likely if low vitamin D – Feb 2020
- Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – Feb 2019
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
- Vitamin D for better sleep video - Dec 2021
- 5X increase in sleep problems in a decade in US Veterans
- Sleep Apnea and Vitamin D - many studies
- Melatonin and Vitamin D - many studies does much more than improve sleep
Narcolepsy with cataplexy is a disabling sleep disorder affecting 0.02% of adults worldwide.
Common narcolepsy symptoms include: Cataplexy (loss of muscle control). Often, narcolepsy may cause you to have a sudden loss of muscle control while awake, usually triggered by strong emotions, such as laughing or crying.
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