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Upper respiratory infection associated with poor Vitamin D Receptor – Oct 2018

Vitamin D receptor genotype influences risk of upper respiratory infection

British Journal of Nutrition Volume 120, Issue 8 28 October 2018 , pp. 891-900, https://doi.org/10.1017/S000711451800209X
David A. Jolliffe (a1), Claire L. Greiller (a1), Charles A. Mein (a2), Mimoza Hoti (a3) ...

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SNP in the vitamin D receptor (VDR) gene is associated with risk of lower respiratory infections. The influence of genetic variation in the vitamin D pathway resulting in susceptibility to upper respiratory infections (URI) has not been investigated. We evaluated the influence of thirty-three SNP in eleven vitamin D pathway genes (DBP, DHCR7, RXRA, CYP2R1, CYP27B1, CYP24A1, CYP3A4, CYP27A1, LRP2, CUBN and VDR) resulting in URI risk in 725 adults in London, UK, using an additive model with adjustment for potential confounders and correction for multiple comparisons. Significant associations in this cohort were investigated in a validation cohort of 737 children in Manchester, UK. In all, three SNP in VDR (rs4334089, rs11568820 and rs7970314) and one SNP in CYP3A4 (rs2740574) were associated with risk of URI in the discovery cohort after adjusting for potential confounders and correcting for multiple comparisons (adjusted incidence rate ratio per additional minor allele ≥1·15, Pfor trend ≤0·030). This association was replicated for rs4334089 in the validation cohort (Pfor trend=0·048) but not for rs11568820, rs7970314 or rs2740574. Carriage of the minor allele of the rs4334089 SNP in VDR was associated with increased susceptibility to URI in children and adult cohorts in the United Kingdom.

Created by admin. Last Modification: Saturday February 16, 2019 22:41:43 GMT-0000 by admin. (Version 5)

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11417 Genes and URI 2.jpg admin 16 Feb, 2019 22:10 155.58 Kb 10
11416 Genes and URI.jpg admin 16 Feb, 2019 22:10 208.55 Kb 10
11415 Genes.jpg admin 16 Feb, 2019 22:10 28.88 Kb 9
11414 VDR URI.pdf PDF 2018 admin 16 Feb, 2019 22:09 714.19 Kb 3
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