UK adults who took Vitamin D were 10 percent less likely to die – Oct 2022

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Real-world evidence for the effectiveness of vitamin D supplementation in reduction of total and cause-specific mortality

J Intern Med . 2022 Oct 8. doi: 10.1111/joim.13578
Sha Sha 1 2 , Thi Mai Ngoc Nguyen 1 2 , Sabine Kuznia 1 2 , Tobias Niedermaier 1 , Anna Zhu 1 2 , Hermann Brenner 1 3 4 5 , Ben Schöttker 1 3

Note: Decreased respiratory mortality by 29%

Background: Meta-analyses of randomized controlled trials (RCTs) demonstrated the efficacy of vitamin D supplementation for reduced cancer mortality, all-cause mortality, and respiratory tract infections. However, whether and to what extent this translates into effectiveness in real-world practice is unknown.

Methods: We assessed the association of vitamin D supplements use (as an over-the-counter drug or as part of a multivitamin product), vitamin D deficiency (25-hydroxyvitamin D (25(OH)D) < 30 nmol/L) and insufficiency (25(OH)D 30-<50 nmol/L) with all-cause and cause-specific mortality in 445,601 participants, aged 40-73 years, from the UK Biobank cohort.

Results: 4.3% and further 20.4% of the study participants reported regularly taking vitamin D or multivitamin supplements, respectively. Still, the majority had either vitamin D deficiency (21.0%) or insufficiency (34.3%). We detected 49 independent determinants of vitamin D deficiency and vitamin D supplement use and used them to adjust Cox regression models for all mortality outcomes. 29,107 (6.5%) participants died during a median follow-up time of 11.8 years.
Both vitamin D deficiency and insufficiency were strongly associated with all mortality outcomes.
Self-reported vitamin D supplements use (83% over-the-counter/17% prescription drugs) and multivitamin intake were significantly associated with 10% and 5% lower all-cause mortality, respectively. Furthermore, regular vitamin D supplement users had 11%, 11% and 29% lower cancer, cardiovascular disease and respiratory disease mortality than non-users, respectively (not significant for cardiovascular disease mortality).

Conclusion: This large study suggests that in the real world, the efficacy of vitamin D supplements in reducing mortality may be at least as good as observed in RCTs.

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500,000 in UK Biobank, aged 40-69, 2006-2010, only 4.3% took Vitamin D

Note: Those people taking Vitamin D probably reduced their mortality in other ways as well:

• Exercise
• Better foods
• Taking Omega-3

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VitaminDWiki - Mortality category contains

{FONT(size="18")} People die sooner if they have low vitamin D{FONT}
{img fileId="2699" width ="450" link="People die sooner if they have low vitamin D – Nov 2014"}
click on image for details

• More vitamin D means fewer deaths – many studies
• Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
• 2,000 IU of Vitamin D daily to German Seniors would save 30,000 lives a year – March 2021
• Dr. Grant on vitamin D and mortality in VitaminDWiki
• Top 10 causes of death - low vitamin D is associated with every cause - Nov 2018
• Taking vitamin D extends life - 56 trials with 100,000 people - Dr. Greger video July 2016
• Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
• Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
• 4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
• Chance of dying in hospital cut in half by just 10 ng higher level of Vitamin D – April 2016
• Senior women having low vitamin D were 2X more likely to die - Sept 2023
• Risk of death after bone fracture was 6.6 X higher if less than 10 ng of vitamin D – June 2017

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This list is automatically updated
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{FONT(size="17")} See also in VitaminDWiki{FONT}

• Dr. Grant on vitamin D and mortality in VitaminDWiki
• Top 10 causes of death - low vitamin D is associated with every cause - Nov 2018
• Taking vitamin D extends life - 56 trials with 100,000 people - Dr. Greger video July 2016
• Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
• 2,000 IU of Vitamin D daily to German Seniors would save 30,000 lives a year – March 2021
• Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
• 4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
• Chance of dying in hospital cut in half by just 10 ng higher level of Vitamin D – April 2016
• Senior women having low vitamin D were 2X more likely to die - Sept 2023
• Risk of death after bone fracture was 6.6 X higher if less than 10 ng of vitamin D – June 2017

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VitaminDWiki - 7 Breathing Mortality studes

This list is automatically updated

Note: Decreased respiratory mortality by 29%