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- Sixteen-Week Vitamin D3 Supplementation Increases Peripheral T Cells in Overweight Black Individuals: Post hoc Analysis of a Randomized, Double-Blinded, Placebo-Controlled Trial
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17 studies in both categories Immunity and Vitamin D intervention - VitaminDwiki - Overview Obesity and Vitamin D contains
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Sixteen-Week Vitamin D3 Supplementation Increases Peripheral T Cells in Overweight Black Individuals: Post hoc Analysis of a Randomized, Double-Blinded, Placebo-Controlled Trial
Nutrients . 2022 Sep 22;14(19):3922. doi: 10.3390/nu14193922.
Yutong Dong 1 2 , Li Chen 1 , Ying Huang 1 , Anas Raed 3 , Robyn Havens 4 , Yanbin Dong 1 , Haidong Zhu 1
Background: Vitamin D is considered to modulate T-cell function, which has been implicated in the treatment of inflammatory conditions. However, there is limited knowledge on the effects of vitamin D and its influences on circulating T-cell profiles in humans, particularly in overweight Black individuals who are more likely to be vitamin D insufficient (serum 25(OH)D concentrations of ≤20 ng/mL). Thus, this study tested the hypothesis that vitamin D supplementation modulates T-cell composition, which is in a dose-dependent manner.Methods: A 16-week randomized, double-blinded, placebo-controlled trial of vitamin D3 supplementation was undertaken in 70 overweight/obese Black people (mean age = 26 years, 82% female) with 25 hydroxyvitamin D ≤ 20 ng/mL at baseline. Subjects were randomly assigned a supervised monthly oral vitamin D3 equivalent to approximately 600 IU/day (n = 17), 2000 IU/day (n = 18), 4000 IU/day (n = 18), or a placebo (n = 17). Fresh peripheral whole blood was collected and CD3+, CD4+ and CD8+ cell counts and percentages were determined by flow cytometry at baseline and at 16 weeks, among 56 subjects who were included in the analyses.
Results: A statistically significant increase in CD3+% in the 2000 IU/day vitamin D3 supplementation group, and increases in CD4+% in the 2000 IU/day and 4000 IU/day vitamin D3 supplementation groups were observed (p-values <; 0.05) from the changes in baseline to 16 weeks. Further adjustments for age, sex and BMI showed that 2000 IU/day vitamin D3 supplementation increased in CD3+ count, CD3%, CD4 count, and CD4%, as compared to the placebo group (p-values < 0.05). Moreover, the highest serum 25(OH)D quantile group had the highest CD3% and CD4%.
Conclusions: Sixteen-week vitamin D3 supplementation increases peripheral blood T-cell numbers and percentages in overweight/obese Black patients with vitamin D insufficiency. This resulting shift in circulating T-cell composition, particularly the increase in T helper cells (CD4+ cells), suggests that vitamin D supplementation may improve immune function in Black individuals.
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17 studies in both categories Immunity and Vitamin D intervention This list is automatically updated
- Viral infections reduced 40% by monthly 100,000 IU Vitamin D – RCT review Aug 2024
- Immune systems not improved with 1,000 IU of vitamin D daily (not a surprise) – Nov 2022
- Immune systems of overweight black women improved by monthly 60,000 IU Vitamin D – RCT Oct 2022
- 2.4 X fewer lower respiratory track infections in infants getting 400 IU of Vitamin D – May 2022
- Immune systems helped by 50,000 IU of vitamin D (weekly for 3 months) – May 2021
- Sublingual Vitamin D sometimes is better than tablet – April 2020
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- Preemie immunity (Treg) vastly improved by 800 IU of Vitamin D daily – RCT July 2019
- Treatment of neonate sepsis greatly aided by Vitamin D – RCT June 2019
- Many Infectious diseases (virus) treated and prevented by Vitamin D – review July 2009
- Respiratory infections (RTI) cut in half by 20,000 IU weekly vitamin D if initially deficient – RCT March 2015
- T-cells increased with monthly doses of 140,000 IU vitamin D – April 2014
- Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention – July 2014
- Antibiotic use cut in half by elderly (over 70) after monthly 60,000 IU of vitamin D – RCT Dec 2013
- Middle ear infection (Otitis Media) and Vitamin D – many studies
- Viral infection reduced 90 percent with 2000 IU of vitamin D – Dec 2010
- Yet again - more than 10000 IU of vitamin D treats MS – July 2011
VitaminDwiki - Overview Obesity and Vitamin D contains
- FACT: People who are obese have less vitamin D in their blood
- FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
- FACT: When obese people lose weight the vitamin D level in their blood increases
- FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
- FACT: 168 trials for vitamin D intervention of obesity as of Dec 2021
- FACT: Less weight gain by senior women with > 30 ng of vitamin D
- FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
- FACT: Obese lost 3X more weight by adding $10 of Vitamin D
- FACT: Those with darker skins were more likely to be obese Sept 2014
- OBSERVATION: Low Vitamin D while pregnancy ==> more obese child and adult
- OBSERVATION: Many mammals had evolved to add fat and vitamin D in the autumn
- and lose both in the Spring - unfortunately humans have forgotten to lose the fat in the Spring
- SPECULATION: Low vitamin D might be one of the causes of obesity – several studies
- SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc. - Obesity category has
444 items See also: Weight loss and Vitamin D - many studies Child Obesity and Vitamin D - many studies Obesity, Virus, and Vitamin D - many studies
Obese need more Vitamin D- Normal weight Obese (50 ng = 125 nanomole)
VitaminDWiki - Weekly, Monthly Vitamin D are typically better than daily - many studies
Immune systems of overweight black women improved by monthly 60,000 IU Vitamin D – RCT Oct 20224134 visitors, last modified 17 Mar, 2024, This page is in the following categories (# of items in each category)Attached files
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