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Immune systems helped by 50,000 IU of vitamin D (weekly for 3 months) – May 2021

Immunomodulatory Effects of Vitamin D Supplementation in a Deficient Population

Int J Mol Sci. 2021 May 10;22(9):5041. doi: 10.3390/ijms22095041.
Mathieu Garand 1, Mohammed Toufiq 1, Parul Singh 1, Susie Shih Yin Huang 1, Sara Tomei 1, Rebecca Mathew 1, Valentina Mattei 1, Mariam Al Wakeel 2, Elham Sharif 2, Souhaila Al Khodor 1

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Most, but not all, responded well to the intervention
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Overview Influenza and vitamin D
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Vitamin D Every Day to Keep the Infection Away 2015 file
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50,000 IU weekly helped >18 health problems

50,000 IU once every 2 weeks has helped 27 health problems

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In addition to its canonical functions, vitamin D has been proposed to be an important mediator of the immune system. Despite ample sunshine, vitamin D deficiency is prevalent (>80%) in the Middle East, resulting in a high rate of supplementation. However, the underlying molecular mechanisms of the specific regimen prescribed and the potential factors affecting an individual's response to vitamin D supplementation are not well characterized. Our objective is to describe the changes in the blood transcriptome and explore the potential mechanisms associated with vitamin D3 supplementation in one hundred vitamin D-deficient women who were given a weekly oral dose (50,000 IU) of vitamin D3 for three months. A high-throughput targeted PCR, composed of 264 genes representing the important blood transcriptomic fingerprints of health and disease states, was performed on pre and post-supplementation blood samples to profile the molecular response to vitamin D3. We identified 54 differentially expressed genes that were strongly modulated by vitamin D3 supplementation. Network analyses showed significant changes in the immune-related pathways such as TLR4/CD14 and IFN receptors, and catabolic processes related to NF-kB, which were subsequently confirmed by gene ontology enrichment analyses. We proposed a model for vitamin D3 response based on the expression changes of molecules involved in the receptor-mediated intra-cellular signaling pathways and the ensuing predicted effects on cytokine production. Overall, vitamin D3 has a strong effect on the immune system, G-coupled protein receptor signaling, and the ubiquitin system. We highlighted the major molecular changes and biological processes induced by vitamin D3, which will help to further investigate the effectiveness of vitamin D3 supplementation among individuals in the Middle East as well as other regions.


Created by admin. Last Modification: Saturday June 5, 2021 15:39:07 GMT-0000 by admin. (Version 6)

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