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Rate of vitamin D supplementation by Blacks increases 16X after getting Multiple Sclerosis – Feb 2018

Vitamin D-Binding Protein Polymorphisms, 25-Hydroxyvitamin D, Sunshine and Multiple Sclerosis

Nutrients 2018,10,184; doi:10.3390/nu10020184
Annette Langer-Gould h*, Robyn M. Lucas , Anny H. Xiang , Jun Wu 3, Lie H. Chen 3,
Edlin Gonzales 3, Samantha Haraszti 3,4, Jessica B. Smith 3, Hong Quach and Lisa F. Barcellos 5

* Correspondence: annette.m.langer-gould at kp.org; Tel.: +1-(626)-564-3992; Fax: +1-(626)-564-3403

VitaminDWiki

Many MSers increase their vitamin D intake, but rarely as much as is needed to reverse the symptoms

Overview MS and vitamin D starts with the following summary

Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

 Download the PDF from VitaminDWiki

Image

Smaller increase in Vitamin D supplementation by Hispanics and Whites,
   but all about 20% if have MS


Blacks have different dominant polymorphisms in the vitamin D-binding protein (DBP) gene that result in higher bioavailable vitamin D than whites. This study tested whether the lack of association between 25-hydroxyvitamin D (25OHD) and multiple sclerosis (MS) risk in blacks and Hispanics is due to differences in these common polymorphisms (rs7041, rs4588). We recruited incident MS cases and controls (blacks 116 cases/131 controls; Hispanics 183/197; whites 247/267) from Kaiser Permanente Southern California. AA is the dominant rs7041 genotype in blacks (70.0%) whereas C is the dominant allele in whites (79.0% AC/CC) and Hispanics (77.1%). Higher 25OHD levels were associated with a lower risk of MS in whites who carried at least one copy of the C allele but not AA carriers. No association was found in Hispanics or blacks regardless of genotype. Higher ultraviolet radiation exposure was associated with a lower risk of MS in blacks (OR = 0.06), Hispanics and whites who carried at least one copy of the C allele but not in others. Racial/ethnic variations in bioavailable vitamin D do not explain the lack of association between 25OHD and MS in blacks and Hispanics. These findings further challenge the biological plausibility of vitamin D deficiency as causal for MS.


Created by admin. Last Modification: Friday July 9, 2021 16:00:27 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
9396 MS Race.jpg admin 23 Feb, 2018 86.81 Kb 626
9395 UV MS.pdf admin 23 Feb, 2018 443.65 Kb 653