Loading...
 
Translate Register Log In Login with facebookLogin and Register

Off Topic: More than 800 mg of Calcium increases risk of Macular Degeneration in seniors by 2.6X – JAMA April 2015

JAMA Ophthalmol. Published online April 09, 2015. doi:10.1001/jamaophthalmol.2015.0514 Caitlin L. M. Kakigi, BA1; Kuldev Singh, MD, MPH2; Sophia Y. Wang, MD3; Wayne T. Enanoria, PhD, MPH4; Shan C. Lin, MD1

Importance Despite widespread use of calcium supplementation among elderly people, little is known about the association between such consumption and the prevalence of age-related macular degeneration (AMD) in the United States.

Objective To investigate the association between self-reported supplementary calcium consumption and the prevalence of AMD in a representative US sample.

Design, Setting, and Participants This cross-sectional study included 3191 participants 40 years and older in the 2007-2008 National Health and Nutrition Examination Survey (NHANES) who were evaluated for the presence or absence of AMD by fundus photography. Participants were interviewed regarding use of dietary supplements and antacids during the 30-day period preceding enrollment. Self-reported supplementary intake of calcium was aggregated and divided into quintiles. Fundus photographs were graded for the presence or absence of AMD. Information regarding demographics, comorbidities, and health-related behaviors was obtained via interview. Multivariable logistic regression models were created to determine the odds of an AMD diagnosis among participants in each quintile of self-reported calcium vs participants not self-reporting supplementary calcium consumption after adjusting for confounders.

Interventions Self-reported use of calcium supplements.

Main Outcomes and Measures Presence or absence of AMD by fundus photography.

Results A total of 248 participants (7.8%) were diagnosed with AMD. Mean ages were 67.2 years for those with AMD and 55.8 for those without AMD. After adjustment for potential confounding variables, study participants who self-reported consumption of more than 800 mg/d of supplementary calcium were found to have higher odds of an AMD diagnosis based on fundus photography evaluation compared with those not self-reporting supplementary calcium consumption (odds ratio, 1.85; 95% CI, 1.25-2.75).
The association between self-reported supplementary calcium intake and AMD was stronger in older than younger individuals (odds ratio, 2.63; 95% CI, 1.52-4.54).
A clear dose-response association between the quintiles of self-reported supplementary calcium intake and AMD was not established.

Conclusions and Relevance Self-reported supplementary calcium consumption is associated with increased prevalence of AMD, with the findings suggesting a threshold rather than a dose-response relationship. The stronger association in older individuals may be due to relatively longer duration of calcium supplementation in older individuals.

PDF is available free at Sci-Hub  10.1001/jamaophthalmol.2015.0514


Calcium No AMD AMD
>800 mg/d 9.4 %17.7 %

Adjusted odds ratio for > 800 mg = 1.85
P value = .004 = unlikely to be a result of chance)

VitaminDWiki comments

  • We have said for 5 years that a person should take less than 750 mg of Calcium
  • The problem might be eliminated if take Vitamin K2 and Magnesium

See also VitaminDWiki

See also web

See any problem with this page? Report it (FINALLY WORKS)