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Need 40 to 60 ng of Vitamin D – 48 scientists call for action – 2015

Scientists' Call to D*action - The Vitamin D Deficiency Epidemic

Grassroots Health


40-75% of the world's population is vitamin D deficient.
The causal link between severe vitamin D deficiency and rickets or the bone disease of osteomalacia is overwhelming, while the link between vitamin D insuffiency and osteoporosis with associated decreased muscle strength and increased risk of falls in osteoporotic humans is well documented by evidence-based intervention studies.
There are newly appreciated associations between vitamin D insufficiency and many other diseases, including tuberculosis, psoriasis, multiple sclerosis, inflammatory bowel disease, type-1 diabetes, high blood pressure, increased heart failure, myopathy, breast and other cancers which are believed to be linked to the non- calcemic actions of the parent vitamin D and its daughter steroid hormone.

Based on the evidence we now have at hand, action is urgent.
It is projected that the incidence of many of these diseases could be reduced by 20%-50% or more, if the occurrence of vitamin D deficiency and insufficiency were eradicated by increasing vitamin D intakes through increased UVB exposure, fortified foods or supplements. The appropriate intake of vitamin D required to effect a significant disease reduction depends on the individual's age, race, lifestyle, and latitude of residence. The latest Institute of Medicine (IOM) report, 2010, indicates 10,000 IU/day is considered the NOAEL (no observed adverse effect level). 4000 IU/ day can be considered a safe upper intake level for adults aged 19 and older.

It is well documented that the darker the skin, the greater the probability of a vitamin D deficiency. Even in southern climates, 55% of African Americans and 22% of Caucasians are deficient.

More than 1 billion people worldwide are affected at a tremendous cost to society.
A Scientists' Call to Action has been issued to alert the public to the importance to have vitamin D serum levels between 40 and 60 nanograms/milliliter (100150 nanomoles/liter) to prevent these diseases. Implementing this level is safe and inexpensive.

The benefit of an adequate vitamin D level to each individual will be better overall health and a reduction in illnesses and, ultimately, a significant reduction in health care costs. The benefit of adequate vitamin D levels to society/businesses is a more productive workforce and, lower health care costs.

The D*action project has as its purpose to serve as a model for public health action on vitamin D. It is a test bed for techniques, and for providing outcome evaluation at a community level.

International Scientists Panel

  • Ahepa University Hospital Thessaloniki ,Greece
  1. Kalliopi Kotsa, MD, Ph.D.
  2. Spyridon Karras , MD, Ph.D.
    Baxter International
  3. Mathew Mizwicki, Ph.D.
    Boston University School of Medicine
  4. Michael F. Holick, Ph.D., M.D.
    Creighton University
  5. Robert P. Heaney, M.D.
  6. Joan M. Lappe, Ph.D., R.N.
    Emory University
  7. Vin Tangpricha, M.D., Ph.D.
    Harvard University
  8. Carlos A. Camargo, Jr., M.D.,
  9. Dr. P.H. Edward Giovannucci, M.D., ScD.
  10. Walter C. Willett, Dr. P.H., M.D.
    Inova Comprehensive Cancer and Research Institute
  11. Donald L. Trump, M.D.
    Institute VitaminDelta
  12. Raimund von Helden, M.D.
    McGill University
  13. John H. White, Ph.D.
    Medical University of Graz, Austria
  14. Stefan Pilz, M.D.
    Medical University of South Carolina
  15. Bruce W. Hollis, Ph.D.
  16. Carol L. Wagner, M.D.
    Mt. San Jacinto College
  17. Laura P. Schoepf, Ph.D.
    National Center for Global Health and Medicine
  18. Tetsuya Mizoue, M.D., Ph.D.
    Oregon State University, Linus Pauling Institute
  19. Adrian F. Gombart, Ph.D.
    Roswell Park Cancer Institute
  20. Candace Johnson, Ph.D.
    Royal National Orthopaedic Hospital, United Kingdom
  21. Benjamin Jacobs, M.D.
    Society For Medical Information and Prevention
  22. Joerg Spitz, M.D.
    Sunlight, Nutrition and Health Research Center
  23. William B. Grant, Ph.D.
    University of Albany - SUNY
  24. JoEllen Welsh, Ph.D.
    University of Alberta
  25. Gerry Schwalfenberg, M.D., CCFP
    University of Angers, France
  26. Cedric Annweiler, M.D., Ph.D.
    University of Auckland
  27. Robert Scragg, M.D., Ph.D.
    University of Birmingham
  28. Martin Hewison, Ph.D.
    University of California Davis
  29. Bruce D. Hammock, Ph.D.
  30. Hari A. Reddy, Ph.D.
  31. Ray Rodriguez, Ph.D.
    University of California Los Angeles
  32. John Adams, M.D.
  33. Milan Fiala, M.D H.
  34. Phillip Koeffler, M.D.
  35. Keith C. Norris, M.D.
    University of California Riverside
  36. Anthony W. Norman, Ph.D.
    University of California San Diego
  37. Richard L. Gallo, M.D., Ph.D.
  38. Cedric F. Garland, Dr. P.H.
  39. Frank C. Garland, Ph.D. +
  40. Edward D. Gorham, Ph.D.
  41. Tissa Hata, M.D.
    University of California San Francisco
  42. David Gardner, M.S., M.D.
  43. Bernard P. Halloran, Ph.D.
    University of Saskatchewan
  44. Susan J. Whiting, Ph.D.
    University of Toronto, Mt Sinai Hospital
  45. Reinhold Vieth, Ph.D.
    Vienna Medical University
  46. Heidi S. Cross, Ph.D.
    Vitamin D Council
  47. John J. Cannell, M.D.
    Wismar University of Applied Sciences
  48. Alexander Wunsch, M.D






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