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Mental health problems cut in half when have adequate level of vitamin D – Jan 2013

Vitamin D and common mental disorders in mid-life: cross-sectional and prospective findings

Clinical Nutrition, Jan 2013
Jane Maddock, Diane J. Berry, Marie-Claude Geoffroy, Chris Power, Elina Hyppönen
MRC Centre of Epidemiology for Child Health/Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, UK

The relationship between vitamin D and common mental disorders (CMDs) remains unclear. We aimed to determine if behaviours affecting vitamin D concentrations differ between individuals with or without CMDs and evaluate, cross-sectionally and prospectively, the extent to which the association between 25(OH)D and CMDs are explained by these behaviours.

Methods Data are from the 1958 British birth cohort (n=7,401). Behaviours were ascertained by questionnaire at age 45 years. CMDs (depression, anxiety, panic, phobia) were assessed using the Clinical Interview Schedule-Revised at 45 years and depression using Mental Health Inventory-5 at 50 years.

Results Participants with CMDs at 45 years differed from others on some but not all vitamin D related behaviours. There were inverse, cross-sectional associations at 45 years of 25(OH)D with depression and panic, which persisted after adjustment for vitamin D related behaviours (OR=0.57, 95%CI: 0.40,0.81 and OR=0.33, 95%CI: 0.40,0.81, respectively). Association between 25(OH)D and subsequent (50 years) risk of depression was non-linear (p=0.01), with lower risk for participants with 25(OH)D between 50 and 85 nmol/l compared with those with lower or higher concentrations.

Conclusion This study provides support for an association of low 25(OH)D concentrations with current and subsequent risk of depression in mid-adulthood.
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Mental health problems cut in half when have adequate level of vitamin D – Jan 2013        
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2022 Mental Illness - 2013.pdf PDF admin 28 Jan, 2013 19:22 485.15 Kb 1968
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