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Childhood mental disorders vs levels of vitamin D – July 2013

Do children with mental disorders have higher prevalence of hypovitaminosis D?

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Mini Zhang1, Keith Cheng1, Robert Rope2, Elizabeth Martin3, Ajit Jetmalani1

Inadequate vitamin D level is associated with various adverse medical outcomes. There is a growing concern that insufficient vitamin D may play a role in the development of psychiatric symptoms. This study aims to answer the question: do children with mental disorders have a higher prevalence of hypovitaminosis D? A retrospective chart review examined 25 hydroxyvitamin D (25(OH)D) levels in youth ages 7 to 17 (n=67) at two Oregon psychiatric residential facilities. Vitamin D deficiency is defined as <20 ng/ml and insufficiency as <30 ng/ml. Diagnoses were organized into six categories. 25(OH)D levels were compared across genders and diagnostic groups using a two-sample t-test and ANOVA, respectively. Statistical differences in prevalence across diagnostic categories were calculated using a Pearson chi-square test. Using the data from Saintonge’s NHANES III study on healthy US children for comparison, 21% of our cohorts were found to be vitamin D deficient and 64% insufficient, in contrast to 14% and 48%, respectively. While our results are not statistically significant, mainly because of small sample size, the overall mean 25(OH)D level in our cohort was insufficient (27.59 ± 9.35 ng/ml), compared to a sufficient mean value of 32.1 ng/ml in the general population.
No statistical significant difference was found in the prevalence across diagnostic categories.

This study found that children with psychiatric disorders might have a higher prevalence of hypovitaminosis D than the general pediatric population.

Although a causal relationship between hypovitaminosis D and psychiatric disorders cannot be derived based on the study design, our study provides initial descriptive data on the prevalence of hypovitaminosis D in children with psychiatric disorders, which has not been previously reported to our knowledge. Prospective studies with a larger sample size and controlled variables would allow more precise analysis of the relationship between hypovitaminosis D and childhood mental disorders.

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See also VitaminDWiki

Attached files

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2889 Mental F1.jpg admin 09 Aug, 2013 00:26 60.17 Kb 1791
2888 mental.pdf PDF 2013 admin 09 Aug, 2013 00:26 565.60 Kb 839