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Maternal Vitamin D not associated with health in China (virually none had a healthy level) – Sept 2021

Association between maternal vitamin D status with pregnancy outcomes and offspring growth in a population of Wuxi, China

Asia Pac J Clin Nutr. 2021 Sep;30(3):464-476. doi: 10.6133/apjcn.202109_30(3).0013.
Xinye Jiang 1, Jianan Lu 2, Yue Zhang 2, Haoyue Teng 2, Jingjing Pei 1, Chen Zhang 2, Bingbing Guo 3, Jieyun Yin 2

12-20 ng 75%

Most Chinese have less than 20 ng level of Vitamin D - meta-analysis Aug 2021 234,000 Chinese
Less than 3 percent of pregnant women in Shanghai had even 30 ng of vitamin D – June 2021

Pregnancy category starts with

793 items in Pregnancy category

 - see also

Healthy pregnancies need lots of vitamin D has the following summary

0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

Background and objectives: The role of maternal vitamin D in infantile growth remains unclear.

Methods and study design: Serum 25-hydroxyvitamin D [25(OH)D] concentrations were examined for pregnancies who visited the Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University from January 2016 to December 2017. Anthropometric measurements of corresponding offspring were performed from birth to 2 to 3 years old. Infantile body mass index (BMI) was transformed into age-, sex- and height- normalized z scores, and Latent Class Growth Mixture (LCGM) model was used to identify trajectories of BMI-Z.

Results: Among the 329 included pregnancy women,

  • 109 (33.13 %), 190 (57.75%) and 30 (9.12%) were defined as vitamin D
  • deficiency [25(OH)D <30 nmol/L], insufficiency [30 nmol/L≤25(OH)D<50 nmol/L] and sufficiency [25(OH)D ≥50 nmol/L], respectively.

When compared with vitamin D sufficiency, maternal vitamin D deficiency was not associated with preterm birth [odds ratio (OR)=2.69, 95% confidence interval (95% CI)=0.57-12.80], small for gestation age (OR=0.99, 95% CI=0.29-3.46), and low birth weight (OR=1.69, 95% CI=0.34-8.51). Similarly, no significant relationships were found between maternal vitamin D concentrations and anthropometric indices (such as weight, length, BMI) during 0 to 3 years old. Furthermore, LCGM model identified two patterns of offspring growth: stable moderate BMI-Z and early transient BMI-Z groups. Maternal vitamin D levels were higher in the former group than the latter (p=0.037); however, maternal vitamin D status appeared to be unrelated with offspring BMI-Z trajectories in multivariable logistic regression models.

Conclusions: Maternal vitamin D deficiency may not be related to adverse pregnancy outcomes as well as offspring growth.

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