Better survival of many cancers if higher level of vitamin D - June 2020

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Vitamin D and Cancer Survival: Does Vitamin D Supplementation Improve the Survival of Patients with Cancer?

Curr Oncol Rep 22, 62 (2020). https://doi.org/10.1007/s11912-020-00929-4
Taisuke Akutsu, Hikaru Kitamura, Shoko Himeiwa, Shinto Kitada, Tatsuya Akasu & Mitsuyoshi Urashima

Table of Contents

Purpose of Review
Clinical evidence suggesting the beneficial effects of vitamin D on survival of patients with cancer has been accumulating. Recent articles were thoroughly reviewed to determine if there is enough evidence to conclude that vitamin D supplementation improves survival of patients with cancer.

Recent Findings
Meta-analyses of observational studies showed that higher blood 25-hydroxyvitamin D levels in patients with cancer at a variety of sites were associated with lower cancer-specific and overall mortalities. Moreover, meta-analyses of randomized clinical trials (RCTs) also suggested that vitamin D supplementation improved the survival of patients with cancer. However, each RCT used in these meta-analyses, as well as very recent RCTs, e.g., the SUNSHINE and the AMATERASU trial, did not show statistical significance in the primary results.

Summary
For now, compelling evidence that vitamin D supplementation effectively improves survival of patients with cancer is lacking. Thus, confirmatory RCTs are still obligatory for the future.
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VitaminDWiki – Cancer - After diagnosis category contains:

• Most cancers reduce vitamin D levels
• Most cancer treatments (chemo, radiation) further lower Vitamin D
• Higher levels of vitamin D minimize many side-effects of cancer therapy
• High levels of vitamin D augment many chemotherapies
• High levels of vitamin D augment cancer immunotherapies
• High levels of vitamin D can kill some cancer cells 1,720 items 12/2023
• Some cancers deactivate the vitamin D receptor

Example VitaminDWiki Studies

• Cancer and Vitamin D - many studies
• Easiest way to treat cancer – take Vitamin D – Nov 2022
• Even after a Cancer diagnosis Vitamin D improves survival – meta-analysis Aug 2022
• Vitamin D is synergistic with many Cancer therapies (radiation in this case) – Aug 2021
• Vitamin D prevents and treats cancer in many ways – May 2021
• Cancer patients need more vitamin D, even those who are supplementing – observational study June 2021
• Metastatic Cancer probably reduced by vitamin D - many studies
• Colorectal Cancer treatment aided by omega-3 plus weekly Vitamin D – RCT Sept 2019
• Radiation therapy, used to treat some cancers, causes less damage if use Vitamin D (or Melatonin) – Aug 2022
• Vitamin D is synergistic with many Cancer therapies (radiation in this case) – Aug 2021
• Vitamin D prevents and treats cancer in many ways – May 2021
• Palliative care is helped by Vitamin D - many studies
• 4X less of one chemo needed after vitamin D receptor activation - June 2020

Breast Cancer

• Breast Cancer survivors with high vitamin D were 3.3 X less likely to have metastases – May 2023
• Breast Cancer survival: 44% with just 10,000 IU of vitamin D per week, 33% with placebo – RCT Dec 2023
• Breast cancer recurred twice as often if have less than 20 ng of vitamin D – Dec 2018
• Breast Cancer chemotherapy 2.7 X more likely to be successful if not vitamin D deficient – Dec 2017

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Vitamin D also PREVENTS many cancers

Cancer category contains:

• Cancer 295 items Overview Cancer and vitamin D
• Cancer and Vitamin D - many studies
• After Cancer Diagnosis 113 items
• Bladder Cancer 28 items
• Breast Cancer 259 items Overview Breast Cancer and Vitamin D
• Colon Cancer 145 items Overview Cancer-Colon and vitamin D
• Leukemia 19 items
• Liver Cancer 17 items
• Lung Cancer 55 items Overview Lung cancer and vitamin D
• Lymphoma Cancer 26 items
• Other Cancer 66 items
• Ovarian Cancer 26 items
• Pancreatic Cancer 58 items
• Prostate Cancer 103 items Overview Prostate Cancer and Vitamin D
• Skin Cancer 121 items Overview Suntan, melanoma and vitamin D
• Childhood Cancers - Vitamin D can help - many studies
• Easiest way to treat cancer – take Vitamin D – Nov 2022
• 13 Cancers are helped by Vitamin D – Biobank July 2023
• 2X increase of 14 cancers in non-seniors in 20 years (low vitamin D) – Sept 2022
• Vitamin D prevents and treats cancer in many ways – May 2021
• Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
• Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
• Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
• 8 ways that Cancer might be prevented by Vitamin D - June 2019
• Cancer stem cells and Vitamin D - many studies
• Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
• Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
• Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
• Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
• Melanoma 25 X more likely if low vitamin D – Feb 2018
• Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

• Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
• Cancer and the Vitamin D Receptor, a primer – Sept 2017
• Vitamin D Receptor (Cancers OR Viruses) - many studies
• Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
• Cancer (general) and VDR 23 articles
• Breast Cancer and VDR 24 articles
• Colon Cancer and VDR 13 articles
• Prostate Cancer and VDR 7 articles
• Skin Cancer and VDR 10 articles
  • Note some Health problems, such as some Cancers, protect themselves
    by actively reducing Receptor activation