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Gastric Cancer patients with more vitamin D more likely to live– Feb 2012

Prognostic effects of 25-hydroxyvitamin D levels in gastric cancer

Chao Ren, Miao-zhen Qiu, De-shen Wang, Hui-yan Luo, Dong-sheng Zhang, Zhi-qiang Wang, Feng-hua Wang, Yu-hong Li, Zhi-wei Zhou and Rui-hua Xu
Journal of Translational Medicine 2012, 10:16 doi:10.1186/1479-5876-10-16, Published: 27 January 2012

Results from large epidemiologic studies on the association between vitamin D and gastric cancer are controversial. Vitamin D significantly promotes apoptosis in the undifferentiated gastric cancer cell, but the prognostic effects of its levels are unknown.

197 gastric carcinoma patients who received treatment in the cancer centre of Sun Yat-sen University from January 2002 to January 2006 were involved in the study. The stored blood drawn before any treatment was assayed for 25-hydroxyvitamin D levels. The clinicopathologic data were collected to examine the prognostic effects of vitamin D.

The mean vitamin D levels of the 197 gastric patients was 49.85 +/- 23.68nmol/L, among whom 114(57.9%) were deficient in Vitamin D(<50nmol/L), 67(34%) were insufficient (50-75nmol/L) and 16(8.1%) were sufficient (>75nmol/L). Clinical stage (P = 0.004) and lymph node metastasis classification (P = 0.009) were inversely associated with vitamin D levels. The patients with high vitamin D levels group ([greater than or equal to]50nmol/L) had a higher overall survival compared with the low vitamin D levels group (<50nmol/L)(P = 0.018). Multivariate analysis indicated that vitamin D levels were an independent prognostic factor of gastric cancer (P = 0.019).

Conclusions Vitamin D deficiency may be associated with poor prognosis in gastric cancer.

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See also VitaminDWiki

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1051 Prognostic effects of vitamin D levels in gastric cancer-2012.pdf PDF admin 01 Feb, 2012 14:30 296.12 Kb 1068
1050 Gastric survival.jpg admin 01 Feb, 2012 14:29 16.74 Kb 1716