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Knee osteoarthritis helped by vitamin D2 (40,000 IU weekly raised 57 % above 30 ng) June 2017

Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients

Nutrients 2017, 9(8), 799; doi:10.3390/nu9080799

VitaminDWiki Summary

This is one of the few studies still using Vitamin D2 (D3 is not available in Thailand)
Vitamin D2 provides about 30% less response than D3 with daily dosing
Vitamin D2 provides about 50% less response than D3 with weekly dosing
This study would have gotten far more than 57% of participants > 30 ng if they had used Vitamin D3

See also VitaminDWiki

Vitamin D, Magnesium, Boron, and Omega-3 all decrease OA
– I use all four and have essentially eliminated my knee osteoarthritis
– Henry Lahore, founder of VitaminDWiki


 Download the PDF from VitaminDWiki

Pacharee Manoy 1, Pongsak Yuktanandana 2, Aree Tanavalee 2, Wilai Anomasiri 3, Srihatach Ngarmukos 2, Thanathep Tanpowpong 2 and Sittisak Honsawek 2,3, * OrcID

  • 1 Program in Medical Sciences, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Thailand
  • 2 Vinai Parkpian Orthopaedic Research Center, Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Thailand
  • 3 Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Thailand

Background: Lower levels of serum 25-hydroxyvitamin D (25(OH)D) are common in osteoarthritis (OA) patients. However, the effect of vitamin D supplementation on muscle strength and physical performance remains unclear. This study will investigate the effects of vitamin D2 supplementation on muscle strength and physical performance in knee OA patients;

Methods: One hundred and seventy-five primary knee OA patients with low levels of serum 25(OH)D (<30 ng/mL) received 40,000 IU vitamin D2 (ergocalciferol) per week for six months. Body composition, muscle strength, physical performance, serum 25(OH)D level, leptin, interlukin-6 (IL-6), parathyroid hormone (PTH), protein carbonyl, and metabolic profile were analyzed;

Results: Baseline mean serum 25(OH)D levels in knee OA patients was 20.73 ng/mL. Regarding baseline vitamin D status, 58.90% of patients had vitamin D insufficiency, and 41.10% had vitamin D deficiency. After vitamin D2 supplementation for six months, mean serum 25(OH)D level was 32.14 ng/mL. For post-supplementation vitamin D status, 57.10% of patients had vitamin D sufficiency and 42.90% had vitamin D insufficiency. From baseline to six months, there was a significant increase in mean serum 25(OH)D level (p < 0.001), while mean LDL cholesterol (p = 0.001), protein carbonyl (p = 0.04), and PTH (p = 0.005) all significantly decreased. Patient quality of life (SF-12) and pain (visual analog scale, VAS) both improved significantly from baseline to the six-month time point (p = 0.005 and p = 0.002, respectively). Knee OA patients demonstrated significant improvement grip strength and physical performance measurements after vitamin D2 supplementation (p < 0.05);

Conclusions: Vitamin D2 supplementation for six months reduced oxidative protein damage, decreased pain (VAS), improved quality of life, and improved grip strength and physical performance in osteoarthritis patients.

Created by admin. Last Modification: Saturday July 29, 2017 11:07:47 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
8233 Osteo D2.pdf PDF 2017 admin 29 Jul, 2017 10:50 1.09 Mb 128
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