Relationship Between Serum Vitamin D Level and Disease Severity in Rheumatoid Arthritis
Clin Med Insights Arthritis Musculoskelet Disord. 2023 Jul 6;16:11795441231182997. doi: 10.1177/11795441231182997
Farhang Soltani Bajestani 1, Nasim Khajavian 2, Davoud Salarbashi 3, Mojtaba Kafili 4, Fatemeh Ashori 5, Jafar Hajavi 6 (Iran)
Background and objective: Rheumatoid arthritis is an autoimmune disease that causes joint pain and reduces daily activities. The aim of this study was to evaluate the serum of vitamin D and its relationship with the severity of the disease in patients with rheumatoid arthritis referred to Allameh Hehlool hospital in Gonabad.
Design and methods: This cross-sectional-analytical study was performed on 92 patients referred to the rheumatology clinic of Allameh Behlool Gonabad Hospital in 2021. After obtaining the permission of the ethics committee, the samples were selected based on the desired criteria. Serum vitamin D levels in patients were measured, and data were collected using a patient information checklist and DAS28-CRP activity questionnaire. Data were analyzed using SPSS software version 16 and using statistically appropriate tests at a significance level less than 5%.
Results: The mean age of the patients was 53.05 ± 12.33 years and most of them (58.7%) were women. Serum vitamin D level was sufficient in 65.2% of patients and the severity of the disease was in the remission in 48.9% of them. The results of chi-square test showed a significant relationship between serum vitamin D levels and disease severity in patients (P < .001).
Conclusions: Serum vitamin D levels were inversely related to disease severity and in most patients with severe disease severity, serum vitamin D levels were inadequate. vitamin D supplementation is recommended in patients with rheumatoid arthritis.
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Highlights of RA studies in VitaminDWiki
RA worse if low Vitamin D
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- Juvenile Rheumatoid Arthritis 8 X more likely if poor Vitamin D receptor – Dec 2017
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Vitamin D in rheumatoid arthritis-towards clinical application – April 2016
- Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
- Rheumatoid arthritis, genes and vitamin D – May 2013
RA Treated by Vitamin D
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- Rheumatic Diseases often treated by Vitamin D, may need 40-60 ng – Oct 2021
- Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018
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- Connective tissue disorders (Lupus, RA, etc) treated by vitamin D – May 2016
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- Big increase in vitamin D supplementation in just 2 years after Swiss rheumatology report – Dec 2013
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- Note: Vitamin D receptor problems (such as RA) are best treated by infrequent large doses of Vitamin D
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