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Rate of injuries from falls cut in half by just 800 IU of vitamin D and exercise – RCT May 2015

Exercise and Vitamin D in Fall Prevention Among Older Women, A Randomized Clinical Trial

JAMA Intern Med. 2015;175(5):703-711. doi:10.1001/jamainternmed.2015.0225.
Kirsti Uusi-Rasi, PhD1,2; Radhika Patil, MSc1; Saija Karinkanta, PhD1; Pekka Kannus, MD, PhD1,3,4; Kari Tokola, MSc1; Christel Lamberg-Allardt, PhD5; Harri Sievänen, DSc1

Importance While vitamin D supplementation and exercise are recommended for prevention of falls for older people, results regarding these 2 factors are contradictory.

VitaminDWiki Summary

Home dwelling women – age 70-80
Had fallen at least once in previous year
2 year experiment

Placebo 800 IU ExerciseExercise
and 800 IU
Falls rates
per 100 person years
Injurious fall rates
per 100 person years

See also VitaminDWiki
Overview Fractures and Falls and Vitamin D 2000 IU of vitamin D substantially reduce falls
Pages listed in BOTH the categories Falls/Fracture and Meta-analysis

How many more Randomized Controlled Trials and Meta-analyses will be needed to actually have doctors prescribe Vitamin D to prevent falls?

Objective To determine the effectiveness of targeted exercise training and vitamin D supplementation in reducing falls and injurious falls among older women.

Design, Setting, and Participants A 2-year randomized, double-blind, placebo-controlled vitamin D and open exercise trial conducted between April 2010 and March 2013 in Tampere, Finland. Participants were 409 home-dwelling women 70 to 80 years old. The main inclusion criteria were at least 1 fall during the previous year, no use of vitamin D supplements, and no contraindication to exercise.

Interventions Four study groups, including placebo without exercise, vitamin D (800 IU/d) without exercise, placebo and exercise, and vitamin D (800 IU/d) and exercise.

Main Outcomes and Measures The primary outcome was monthly reported falls. Injurious falls and the number of fallers and injured fallers were reported as secondary outcomes. In addition, bone density, physical functioning (muscle strength, balance, and mobility), and vitamin D metabolism were assessed.

Results Intent-to-treat analyses showed that neither vitamin D nor exercise reduced falls. Fall rates per 100 person-years were 118.2, 132.1, 120.7, and 113.1 in the placebo without exercise, vitamin D without exercise, placebo and exercise, and vitamin D and exercise study groups, respectively; however, injurious fall rates were 13.2, 12.9, 6.5, and 5.0, respectively. Hazard ratios for injured fallers were significantly lower among exercisers with vitamin D (0.38; 95% CI, 0.17-0.83) and without vitamin D (0.47; 95% CI, 0.23-0.99). Vitamin D maintained femoral neck bone mineral density and increased tibial trabecular density slightly. However, only exercise improved muscle strength and balance. Vitamin D did not enhance exercise effects on physical functioning.

Conclusions and Relevance The rate of injurious falls and injured fallers more than halved with strength and balance training in home-dwelling older women, while neither exercise nor vitamin D affected the rate of falls. Exercise improved physical functioning. Future research is needed to determine the role of vitamin D in the enhancement of strength, balance, and mobility.

Trial Registration clinicaltrials.gov Identifier: NCT00986466

New Studies "D"-bunk Benefits Of Vitamin D: Healthcare Triage News

Video commentary about this an a second study had the following graphic of the data

Attached files

ID Name Comment Uploaded Size Downloads
5912 Falls with Injuries.jpg admin 13 Sep, 2015 13.51 Kb 690