Aberrant intestinal microbiota in individuals with prediabetes.
Diabetologia. 2018 Apr;61(4):810-820. doi: 10.1007/s00125-018-4550-1
Allin KH1,2, Tremaroli V3,4, Caesar R5,6, Jensen BAH7, Damgaard MTF7, Bahl MI8, Licht TR8, Hansen TH9, Nielsen T9, Dantoft TM10, Linneberg A10,11, Jørgensen T10,12,13, Vestergaard H9,14, Kristiansen K7, Franks PW15,16,17; IMI-DIRECT consortium, Hansen T9,18, Bäckhed F5,6,19, Pedersen O20,21.
AIMS/HYPOTHESIS:
Individuals with type 2 diabetes have aberrant intestinal microbiota. However, recent studies suggest that metformin alters the composition and functional potential of gut microbiota, thereby interfering with the diabetes-related microbial signatures. We tested whether specific gut microbiota profiles are associated with prediabetes (defined as fasting plasma glucose of 6.1-7.0 mmol/l or HbA1c of 42-48 mmol/mol [6.0-6.5%]) and a range of clinical biomarkers of poor metabolic health.
METHODS:
In the present case-control study, we analysed the gut microbiota of 134 Danish adults with prediabetes, overweight, insulin resistance, dyslipidaemia and low-grade inflammation and 134 age- and sex-matched individuals with normal glucose regulation.
RESULTS:
We found that five bacterial genera and 36 operational taxonomic units (OTUs) were differentially abundant between individuals with prediabetes and those with normal glucose regulation. At the genus level, the abundance of Clostridium was decreased (mean log2 fold change -0.64 (SEM 0.23), p adj = 0.0497), whereas the abundances of Dorea, [Ruminococcus], Sutterella and Streptococcus were increased (mean log2 fold change 0.51 (SEM 0.12), p adj = 5 × 10-4; 0.51 (SEM 0.11), p adj = 1 × 10-4; 0.60 (SEM 0.21), p adj = 0.0497; and 0.92 (SEM 0.21), p adj = 4 × 10-4, respectively). The two OTUs that differed the most were a member of the order Clostridiales (OTU 146564) and Akkermansia muciniphila, which both displayed lower abundance among individuals with prediabetes (mean log2 fold change -1.74 (SEM 0.41), p adj = 2 × 10-3 and -1.65 (SEM 0.34), p adj = 4 × 10-4, respectively). Faecal transfer from donors with prediabetes or screen-detected, drug-naive type 2 diabetes to germfree Swiss Webster or conventional C57BL/6 J mice did not induce impaired glucose regulation in recipient mice.
Microbiome category listing has
Items in both categories Gut and Microbiome are listed here:
- Fecal transplants finally approved to fight C.difficile – July 2024
- Nutrients, Microbiome, and Chronic Diseases - April 2023
- Vitamin D levels change Gut Microbiota – 25 study review Sept 2021
- Gut Microbiota: improved by Vitamin D – narrative review – July 2021
- Vitamin D and the Host-Gut Microbiome: A Brief Overview– June 2020
- Migraine Headache association with poor gut – Feb 2020
- Gut microbiome altered by many nutrients – such as Vitamin D – Jan 2020
- Strong interactions between Vitamin D and the gut microbiota via Butyrate and VDR – Dec 2019
- Vitamin D, Gut Microbiota, and Chemo-radiation interactions – Dec 2019
- Inflammatory bowel disease, gut bionome and Vitamin D Receptor – 2018
- Resveratrol, Metabolic Syndrome, and Gut Microbiota – Nov 2018
- Microbiome improvement by probiotics can be augmented with phages (gut, etc.)
- Gut bacteria of Crohn's disease patients improved by Vitamin D – March 2018
- Gut microbiome massively changed by weekly vitamin D – July 2015
- Gut Microbiota: The Neglected Endocrine Organ (vitamin D not mentioned) – July 2014
CONCLUSIONS/INTERPRETATION:
Collectively, our data show that individuals with prediabetes have aberrant intestinal microbiota characterised by a decreased abundance of the genus Clostridium and the mucin-degrading bacterium A. muciniphila. Our findings are comparable to observations in overt chronic diseases characterised by low-grade inflammation.
| 3624 visitors, last modified 26 Sep, 2021, |