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Obese responded to weekly vitamin D better than non-obese – RCT March 2018

The effects of three regimens of cholecalciferol (vitamin D3) supplementation on vitamin D deficiency in non-obese and obese females.

Arch Med Sci Atheroscler Dis. 2018 Mar 27;3:e60-e67. doi: 10.5114/amsad.2018.74784
Imga NN1, Berker D1, Can B1, Guler S1.

VitaminDWiki

This study: Daily vs. Weekly 50,000 IU oral Vitamin D for 8 weeks


A sampling of the many RCT which found weekly to work well (often 50,000 IU was used)

Weekly may be BETTER than daily


Non weekly

1 or 2 per month may be BETTER than daily

Take vitamin D3 daily or weekly has the following

  • Notional chart for Vitamin D supplementation for levels < 30 nanograms

see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=2475

  • Notional chart of Vitamin D benefit vs dosing frequency for > 50 nanograms

see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=2475

Higher gradient (steeper slide) resulting from infrequent dosing results in more Vitamin D getting into the cells.
Note: Virtually all cells of the body can utilize/activate Vitamin D, no liver or kidney needed
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 Download the PDF from VitaminDWiki
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Note: vitamin D levels dropped by the 6th month asthere was no dosing after the 8th week

Vitamin D deficiency is a common health problem worldwide and tends to be a risk factor for all-cause mortality. We evaluated the effect of continuous low-dose oral daily and loading dose of oral weekly and loading monthly intramuscular (IM) vitamin D3 regimens on circulating levels of total 25(OH)D and in vitamin D deficient females, and between non-obese and obese subgroups.

MATERIAL AND METHODS:
A total of 231 vitamin D deficient females were included to the study. According to treatment regimen, patients were divided into three groups:

  • daily continuous oral,
  • loading dose of weekly oral
  • and monthly intramuscular.

All patients in treatment groups were divided into non-obese (105) and obese (126) groups. Serum 25(OH)D and parathormone (PTH) levels were evaluated at baseline and at the third and sixth month.

RESULTS:
In obese patients oral weekly loading regimen and in non-obese patients oral daily continuous regimens were found to be more potent. Baseline PTH levels decreased when compared with the third and sixth months (p < 0.001), but between the third and sixth months it was not changed (p = 0.783).

CONCLUSIONS:

  • Oral daily regimen in non-obese patients and
  • loading weekly oral regimen in obese patients

were more effective in achieving the target levels of 25(OH)D concentration above 30 ng/ml and provided a stable plasma vitamin D concentration over a long period of time.

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Created by admin. Last Modification: Sunday October 6, 2019 01:48:18 GMT-0000 by admin. (Version 12)

Attached files

ID Name Comment Uploaded Size Downloads
11896 Weekly.jpg admin 02 May, 2019 20:15 34.44 Kb 71
11895 Weekly.pdf PDF 2018 admin 02 May, 2019 20:14 298.20 Kb 30
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