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Obese lost more weight on diet if added 50,000 IU of vitamin D weekly – many RCTs


Lost more weight with 50,000 IU weekly - RCT Sept 2018

Effect of vitamin D supplementation along with weight loss diet on meta-inflammation and fat mass in obese subjects with vitamin D deficiency: a double-blind placebo-controlled randomized clinical trial
Clin Endocrinol (Oxf). 2018 Sep 24. doi: 10.1111/cen.13861. [Epub ahead of print]
Lotfi-Dizaji L1, Mahboob S2, Aliashrafi S1, Vaghef-Mehrabany E1, Ebrahimi-Mameghani M3, Morovati A1.
1 Student Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Nutritional Biochemistry, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Nutrition Research Center, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

VitaminDWiki
Vitamin DPlacebo p value
kilogram before99.6099.65-
kilogram after92.6194.860.038 (good)

VitaminDWiki suggests significantly more weight loss if any of the following

  1. Started Vitamin D about 8 weeks before diet
  2. Used more vitamin D
  3. Used a gut-friendly form of Vitamin D
  4. Started with Vitamin D loading dose
  5. Included exercise - even walking
  6. Intervention lasted longer


BACKGROUND & AIMS:
Low serum 25-hydroxy-vitamin D (25OHD) is common in obese people. Obesity is associated with a state of low-grade inflammation (meta-inflammation). There is increasing evidence indicating that vitamin D has anti-adipogenic activity and immunoregulatory effect. This study aimed to assess the effect of vitamin D supplementation on meta-inflammation and fat mass in obese subjects with vitamin D deficiency.

MATERIALS AND METHODS:
In this double-blind placebo-controlled randomized clinical trial, 44 obese subjects with vitamin D deficiency (25OHD < 50 nmol/L) were assigned into vitamin D (a weight reduction diet + bolus weekly dose of 50000 IU vitamin D) or placebo group (weight reduction diet + edible paraffin weekly) for 12 weeks. Weight, fat mass and serum levels of 25OHD, Calcium, Parathyroid hormone (PTH), Monocyte chemoattractant protein 1 (MCP-1), Interleukin-1β (IL-1β), and Toll like receptor 4 (TLR-4) were assessed before and after the intervention.

RESULTS:
Vitamin D supplementation resulted in significant increase of serum 25OHD level (P<0.001), and significant decrease in PTH (P<0.001), MCP-1 (p<0.05), IL-1β (p< 0.05), and TLR-4 (P<0.05); compared to the baseline values in vitamin D group. Weight, BMI and fat mass decreased in both groups (P<0.05). Between the groups, there were significant decrease in weight, fat mass and serum MCP-1 concentrations and significant increase in serum 25OHD and PTH concentrations after intervention with vitamin D supplementation compared to placebo (p<0.05).

CONCLUSIONS:
Improvement in vitamin D status in obese subjects with vitamin D deficiency in combination weight loss diet resulted in weight, fat mass, and MCP-1 decrease. Weight loss and vitamin D supplementation may act synergistically to reduce levels of meta-inflammation.


Lost more weight with 50,000 IU Vitamin D weekly and daily Calcium - RCT Nov 2018

A high weekly dose of cholecalciferol and calcium supplement enhances weight loss and improves health biomarkers in obese women.
Nutr Res. 2018 Nov;59:53-64. doi: 10.1016/j.nutres.2018.07.011. Epub 2018 Jul 25.
Subih HS1, Zueter Z2, Obeidat BM2, Al-Qudah MA3, Janakat S2, Hammoh F4, Sharkas G5, Bawadi HA2.
1 Dept of Nutrition and Food Technology, Faculty of Agriculture, Jordan University of Science and Technology, Irbid, Jordan. hssubih at just.edu.jo.
2 Department of Nutrition and Food Technology, Faculty of Agriculture, Jordan University of Science and Technology, Irbid, Jordan.
3 Department of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
4 Department of Nutrition and Dietetics, Faculty of Health Sciences, American University of Madaba, Madaba, Jordan.
5 Field Epidemiology Training Program, Non-communicable Diseases, Ministry of Health, Amman, Jordan.

Obesity, a chronic condition associated with several life-threatening diseases, affects a significant proportion of the global population and has long been associated with vitamin D deficiency. The prevalence of both obesity and vitamin D deficiency has increased dramatically in Jordan in recent decades, especially among women. Few studies in Jordan and the surrounding area address this issue. In this study, we hypothesize that calcium and vitamin D have beneficial effects on weight reduction and metabolic profile in obese women. The objective of this study is to examine the effect of vitamin D3 and calcium supplementation on anthropometric measurements and some blood metabolites. Forty-five obese female subjects with vitamin D deficiency were recruited by a dietitian and randomly assigned to the same weight loss diet in addition to the following treatments (4 groups): control (CON), no prescribed supplements; vitamin D3 (Diet/D), given a high weekly dose of cholecalciferol (50 000 IU/subject/week); calcium (Diet/Ca), given 1200 mg/dL calcium/subject/day; vitamin D3 plus Ca (Diet/Ca/D), given cholecalciferol (50 000 IU/subject/week) and calcium (1200 mg/dL calcium/subject/day).
Results revealed that after 3 months of supplementation, the Diet/Ca/D group subjects experienced a significant reduction (P ≤ .05) in

  • weight (10.49 kg),
  • BMI (4.61 ± 2 kg/m2),
  • waist circumference (11.41 ± 8.9 cm),
  • body fat percentage (2.43 ± 1.7%),
  • FBG (25.81 ± 11.4 mg/dL),
  • PTH (27.58 ± 8.9 pg/mL),
  • cholesterol (0.56 ± 0.2 mmol/L), and
  • triglycerides (0.53 ± 0.21 mmol/L)

when compared to the Diet/Ca and the CON groups. Interestingly, however, the CON group showed a significant increase in serum PTH concentration (9.51 ± 3.8 pg/mL, P ≤ .05). Based on these results, a combined Ca and vitamin D3 supplement appears to enhance weight loss and improve some of the blood metabolic profiles in obese women subjected to a weight loss diet, thus supporting our study hypothesis.


Obese responded to weekly vitamin D better than non-obese – RCT March 2018

Obese responded to weekly vitamin D better than non-obese – RCT March 2018


Obese taking 50,000 IU of vitamin D weekly lost more weight (again) – RCT Dec 2019

Obese taking 50,000 IU of vitamin D weekly lost more weight (again) – RCT Dec 2019


VitaminDWiki Obesity pages with RCT in title (41 RCT as of Dec 2021)

This list is automatically updated

Items found: 44
Title Modified
Response to Vitamin D varies with genes (3,000 IU, weight loss in this RCT) – March 2022 22 Mar, 2022
HIIT reduced appetite of sedentary overweight men, adding a bit of vitamin D helped a bit – RCT Feb 2022 24 Feb, 2022
4,000 IU of Vitamin D is too small a dose to help Obese - RCT Feb 2022 09 Feb, 2022
Single 200,000 IU of vitamin D did not benefit the obese in various ways (not a surprise) – RCT Feb 2021 27 Jun, 2021
Need 3X more Vitamin D (or take semi-activated vitamin D) if have poor gut – small RCT May 2021 26 May, 2021
Overweight elderly respond well to 3600 IU Vitamin D daily for a year – RCT May 2021 07 May, 2021
More Magnesium needed by obese (Mg Sulfate, women in this case) – RCT Dec 2021 03 Mar, 2021
Dieters lost 5 more pounds if achieved more than 32 ng of vitamin D – RCT March 2014 08 Jan, 2021
Obesity not helped by daily vitamin D (summary of 20 RCTs using 100 IU to 8,000 IU) – July 2020 10 Jul, 2020
Little weight loss in obese children from very small amount of vitamin D (1200 IU) – RCT April 2020 19 Jun, 2020
20,000 IU of Vitamin D weekly gave many benefits – RCT Aug 2019 17 Jan, 2020
Obese lost more weight on diet if added 50,000 IU of vitamin D weekly – many RCTs 25 Dec, 2019
Obese taking 50,000 IU of vitamin D weekly lost more weight (again) – RCT Dec 2019 25 Dec, 2019
Obese responded to weekly vitamin D better than non-obese – RCT March 2018 22 Aug, 2019
Severely Obese not helped much by 50,000 IU of vitamin D weekly for 8 weeks – RCT June 2019 21 Aug, 2019
4 weeks of Omega-3 better than 2 week 800 calorie diet before Bariatric Surgery – RCT March 2019 23 Mar, 2019
Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018 02 Mar, 2019
Waist circumference dropped from 105 cm to 98 cm with just 18 Vitamin D pills - RCT Dec 2018 09 Feb, 2019
Daily, monthly Vitamin D had similar great benefits, more than 6 months needed – RCT Dec 2018 09 Feb, 2019
Fat loss, etc. if respond well to 3 years of Vitamin K2 (MK-7, 180 ug) – RCT Jan 2018 09 Jan, 2019
Omega-3 reduced vitamin D3 inflammation for obese – RCT Jan 2013 03 Nov, 2018
Obese youths 2X less likely to develop Metabolic Syndrome if take Omega-3 – RCT April 2016 12 Oct, 2018
BMI reduced by Vitamin D (not much reduction – only got VitD to 26 ng) – RCT Feb 2018 24 Feb, 2018
Less weight gain if add Vitamin D, even if have a high fat diet (in rats) – RCT Dec 2017 02 Jan, 2018
Obese helped with resistance training by 4000 IU of vitamin D – RCT Aug 2012 23 Aug, 2017
Fatty liver disease in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016 09 Jul, 2017
Overweight and obese lost 12 lbs with vitamin D in 6 months– RCT May 2015 01 Jan, 2017
Obese diabetics with dark skins not benefit from 6,000 IU of vitamin D daily (no surprise) – RCT March 2015 19 Dec, 2016
Loading dose greatly improves subsequent daily Vitamin D if have liver fibrosis – RCT Nov 2016 18 Nov, 2016
Obese teens need more than 2,000 IU of vitamin D for 3 months– RCT Feb 2015 02 Nov, 2016
Obese need more Vitamin D: Volume dilution, IU per pound, or BMI – RCT Dec 2012 14 Aug, 2016
Obese need 2.5 IU of vitamin D per kg to increase 1 ng (about 3.4 X more) – RCT Sept 2013 14 Aug, 2016
5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT Dec 2015 06 Aug, 2016
Overweight women on caloric restriction diet got 3X benefits from 8 weeks of Omega-3 – RCT Dec 2015 15 Dec, 2015
Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015 05 Mar, 2015
24 ng lower response to Vitamin D due to obesity, low initial Vitamin D, and genetics – RCT Feb 2015 24 Feb, 2015
Weight loss includes muscle loss unless add vitamin D, whey and leucine – RCT Feb 2015 07 Feb, 2015
Obese may need 40 percent more vitamin D - RCT Aug 2014 06 Nov, 2014
Weight loss with salacia reticulata and just 200 IU of vitamin D – RCT 2013 16 Aug, 2014
4,000 IU vitamin D did not change 25OHD to Vitamin D Binding Protein ratio for obese – RCT April 2013 24 Apr, 2013
Insulin sensitivity in obese adolescents greatly improved with 4000 IU of vitamin D - RCT April 2013 20 Mar, 2013
Higher BMI decreased response to 700 IU vitamin D – RCT 2008 26 Feb, 2013
Lost more weight on low calorie diet if add 600 mg Ca and just 150 IU vitamin D – RCT Jan 2013 10 Jan, 2013
Calcium and vitamin D aided weight loss – RCT Sept 2010 13 Sep, 2010



- - - - - The following are NOT RCT - - - - - -


Obesity is associated with low Vitamin D (and treated by D as well) – Aug 2019 has the following

Fast weight loss by Obese: Summary of the data as of Sept 2019
1) 50,000 IU Vitamin D weekly for at least 6 months
   If gut problems, should use a gut-friendly form of vitamin D
2) Add calorie restriction diet and light exercise after ~2 months*
   * Vitamin D levels must be above 30ng/ml to help with weight loss
   * Start losing weight 2 months sooner if take a 50,000 IU daily for a week
3) More weight loss if also add Magnesium or cofactors
   30% Improved Vitamin D response with Magnesium - a Vitamin D Cofactor
   Note: Magnesium reduces weight loss by itself as well
   20% improved vitamin D response if also add Omega-3 a Vitamin D Cofactor
  Note: Omega-3 reduces weight loss by itself as well
4) More weight loss if also improve activation of Vitamin D Receptor
   Vitamin D Receptor activator: 0-30% improved Vitamin D response
   Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
Update Dec 2019 - Dr. Greger plant-based eating (not diet) for both weight loss and health.
  His book does not mention Vitamin D nor Adenovirus


Overview Obesity and Vitamin D contains the following summary


Weight loss on low-calorie diet: 7 lbs more lost if got lots of Vitamin D – June 2021

Weight loss on low-calorie diet: 7 lbs more lost if got lots of Vitamin D – June 2021


2.3 X more weight loss in those who had low vitamin D levels and took some – Dec 2019

2.3 X more weight loss in those who had low vitamin D levels and took some – Dec 2019


Lost 19 lbs more if add vitamin D to calorie restriction and walking program– July 2018

Lost 19 lbs more if add vitamin D to calorie restriction and walking program– July 2018


Overweight and obese lost 12 lbs with vitamin D in 6 months– RCT May 2015

Overweight and obese lost 12 lbs with vitamin D in 6 months– RCT May 2015

Note: Lose more weight if add Magnesium, exercise, Omega-3, or VDR activators

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