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Effect of vitamin D supplementation along with weight loss diet on meta-inflammation and fat mass in obese subjects with vitamin D deficiency: a double-blind placebo-controlled randomized clinical trial
Clin Endocrinol (Oxf). 2018 Sep 24. doi: 10.1111/cen.13861. [Epub ahead of print]
Lotfi-Dizaji L1, Mahboob S2, Aliashrafi S1, Vaghef-Mehrabany E1, Ebrahimi-Mameghani M3, Morovati A1.
1 Student Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Nutritional Biochemistry, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Nutrition Research Center, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
|Vitamin D||Placebo||p value|
|kilogram after||92.61||94.86||0.038 (good)|
VitaminDWiki suggests significantly more weight loss if any of the following
- Started Vitamin D about 8 weeks before diet
- Used more vitamin D
- Used a gut-friendly form of Vitamin D
- Started with Vitamin D loading dose
- Included exercise - even walking
- Intervention lasted longer
Fast weight loss by Obese: Summary of the data as of Sept 2019
1) 50,000 IU Vitamin D weekly for at least 6 months
If gut problems, should use a gut-friendly form of vitamin D
2) Add calorie restriction diet and light exercise after ~2 months*
* Vitamin D levels must be above 30ng/ml to help with weight loss
* Start losing weight 2 months sooner if take a 50,000 IU daily for a week
3) More weight loss if also add Magnesium or cofactors
30% Improved Vitamin D response with Magnesium - a Vitamin D Cofactor
Note: Magnesium reduces weight loss by itself as well
20% improved vitamin D response if also add Omega-3 a Vitamin D Cofactor
Note: Omega-3 reduces weight loss by itself as well
4) More weight loss if also improve activation of Vitamin D Receptor
Vitamin D Receptor activator: 0-30% improved Vitamin D response
Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
Update Dec 2019 - Dr. Greger plant-based eating (not diet) for both weight loss and health.
His book does not mention Vitamin D nor Adenovirus
Overview Obesity and Vitamin D contains the following summary
- FACT: People who are obese have less vitamin D in their blood
- FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
- FACT: When obese people lose weight the vitamin D level in their blood increases
- FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
- FACT: 153 trials for vitamin D intervention of obesity as of Sept 2020
- FACT: Less weight gain by senior women with > 30 ng of vitamin D
- FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
- FACT: Obese lost 3X more weight by adding $10 of Vitamin D
- FACT: Those with darker skins were more likely to be obese Sept 2014
- OBSERVATION: Many mammals had evolved to add fat and vitamin D in the autumn
- and lose both in the Spring - unfortunately humans have forgotten to lose the fat in the Spring
- SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc.
- Obesity category has
PDF is available free at Sci-Hub 10.1111/cen.13861
BACKGROUND & AIMS:
Low serum 25-hydroxy-vitamin D (25OHD) is common in obese people. Obesity is associated with a state of low-grade inflammation (meta-inflammation). There is increasing evidence indicating that vitamin D has anti-adipogenic activity and immunoregulatory effect. This study aimed to assess the effect of vitamin D supplementation on meta-inflammation and fat mass in obese subjects with vitamin D deficiency.
MATERIALS AND METHODS:
In this double-blind placebo-controlled randomized clinical trial, 44 obese subjects with vitamin D deficiency (25OHD < 50 nmol/L) were assigned into vitamin D (a weight reduction diet + bolus weekly dose of 50000 IU vitamin D) or placebo group (weight reduction diet + edible paraffin weekly) for 12 weeks. Weight, fat mass and serum levels of 25OHD, Calcium, Parathyroid hormone (PTH), Monocyte chemoattractant protein 1 (MCP-1), Interleukin-1β (IL-1β), and Toll like receptor 4 (TLR-4) were assessed before and after the intervention.
Vitamin D supplementation resulted in significant increase of serum 25OHD level (P<0.001), and significant decrease in PTH (P<0.001), MCP-1 (p<0.05), IL-1β (p< 0.05), and TLR-4 (P<0.05); compared to the baseline values in vitamin D group. Weight, BMI and fat mass decreased in both groups (P<0.05). Between the groups, there were significant decrease in weight, fat mass and serum MCP-1 concentrations and significant increase in serum 25OHD and PTH concentrations after intervention with vitamin D supplementation compared to placebo (p<0.05).
Improvement in vitamin D status in obese subjects with vitamin D deficiency in combination weight loss diet resulted in weight, fat mass, and MCP-1 decrease. Weight loss and vitamin D supplementation may act synergistically to reduce levels of meta-inflammation.
A high weekly dose of cholecalciferol and calcium supplement enhances weight loss and improves health biomarkers in obese women.
Nutr Res. 2018 Nov;59:53-64. doi: 10.1016/j.nutres.2018.07.011. Epub 2018 Jul 25.
Subih HS1, Zueter Z2, Obeidat BM2, Al-Qudah MA3, Janakat S2, Hammoh F4, Sharkas G5, Bawadi HA2.
1 Dept of Nutrition and Food Technology, Faculty of Agriculture, Jordan University of Science and Technology, Irbid, Jordan. hssubih at just.edu.jo.
2 Department of Nutrition and Food Technology, Faculty of Agriculture, Jordan University of Science and Technology, Irbid, Jordan.
3 Department of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
4 Department of Nutrition and Dietetics, Faculty of Health Sciences, American University of Madaba, Madaba, Jordan.
5 Field Epidemiology Training Program, Non-communicable Diseases, Ministry of Health, Amman, Jordan.
Obesity, a chronic condition associated with several life-threatening diseases, affects a significant proportion of the global population and has long been associated with vitamin D deficiency. The prevalence of both obesity and vitamin D deficiency has increased dramatically in Jordan in recent decades, especially among women. Few studies in Jordan and the surrounding area address this issue. In this study, we hypothesize that calcium and vitamin D have beneficial effects on weight reduction and metabolic profile in obese women. The objective of this study is to examine the effect of vitamin D3 and calcium supplementation on anthropometric measurements and some blood metabolites. Forty-five obese female subjects with vitamin D deficiency were recruited by a dietitian and randomly assigned to the same weight loss diet in addition to the following treatments (4 groups): control (CON), no prescribed supplements; vitamin D3 (Diet/D), given a high weekly dose of cholecalciferol (50 000 IU/subject/week); calcium (Diet/Ca), given 1200 mg/dL calcium/subject/day; vitamin D3 plus Ca (Diet/Ca/D), given cholecalciferol (50 000 IU/subject/week) and calcium (1200 mg/dL calcium/subject/day).
Results revealed that after 3 months of supplementation, the Diet/Ca/D group subjects experienced a significant reduction (P ≤ .05) in
- weight (10.49 kg),
- BMI (4.61 ± 2 kg/m2),
- waist circumference (11.41 ± 8.9 cm),
- body fat percentage (2.43 ± 1.7%),
- FBG (25.81 ± 11.4 mg/dL),
- PTH (27.58 ± 8.9 pg/mL),
- cholesterol (0.56 ± 0.2 mmol/L), and
- triglycerides (0.53 ± 0.21 mmol/L)
when compared to the Diet/Ca and the CON groups. Interestingly, however, the CON group showed a significant increase in serum PTH concentration (9.51 ± 3.8 pg/mL, P ≤ .05). Based on these results, a combined Ca and vitamin D3 supplement appears to enhance weight loss and improve some of the blood metabolic profiles in obese women subjected to a weight loss diet, thus supporting our study hypothesis.
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Obese lost more weight on diet if added 50,000 IU of vitamin D weekly – many RCTs
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