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Depression in seniors treated by weekly 50,000 IU of vitamin D – RCT Sept 2018

Effect of vitamin D supplementation on depression in elderly patients: A randomized clinical trial.

Clin Nutr. 2018 Sep 19. pii: S0261-5614(18)32449-X. doi: 10.1016/j.clnu.2018.09.011. [Epub ahead of print]

  • 8 weeks raised vitamin D levels from 23 ng to 43 ng
  • Depression sccore dropped from 9.3 to 7.5
  • There would have even more reduction in depression score if trial had lasted long enough for the vitamin D levels to plateau – say 12 to 20 weeks

GDS-15 from web

Alavi NM1, Khademalhoseini S2, Vakili Z3, Assarian F4.
1 Trauma Nursing Research Center, Kashan University of Medical Sciences, Iran.
2 Trauma Nursing Research Center, Kashan U. of Medical Sciences, Iran. saeedkhadem1251369 at yahoo.com.
3 Department of Pathology, Kashan University of Medical Sciences, Iran.
4 Department of Psychiatry, Kashan University of Medical Sciences, Iran.

BACKGROUND & AIMS: Treatment of depression in elderly population is a crucial issue. The effect of vitamin D supplementation on treatment of depression in older adults was investigated in this clinical trial.

It was an 8-week, randomized clinical trial of vitamin D supplementation and placebo in the treatment of depression in 3 psychiatric clinics. The study sample included 78 older adults aged over 60 years with moderate to severe depression. Subjects were randomly allocated to receive 50,000 U vitamin D3 pearl weekly for 8 weeks or placebo (39 subjects in each group). Main outcome measures comprised Geriatric Depression Scale-15 (GDS-15) questionnaire and 25-hydroxyvitamin D3 [25(OH)D3]. The analysis utilized Mann Whitney U test, Wilcoxon signed ranks test, chi-square and multiple regression analysis.

The mean baseline 25(OH)D3 concentration was 22.57 ± 6.2 ng/ml in vitamin D group and 21.2 ± 5.8 ng/ml in placebo group (p = 0.16). The Vitamin D increased to 43.48 ± 9.5 ng/ml in vitamin D and 25.9 ± 15.3 ng/ml in placebo group. The depression score decreased from 9.25 to 7.48 in vitamin D group (p = 0.0001), while there was a non-significant increase in depression score in placebo group. The multiple regression analysis showed that the vitamin D group and the score of depression before study were the variables that could explain 81.8% of depression score after intervention.

CONCLUSION: The findings indicated that vitamin D supplementation can improve the depression score in persons aged 60 and over.

Created by admin. Last Modification: Monday October 15, 2018 12:05:25 GMT-0000 by admin. (Version 3)

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10689 Depression Score.jpg admin 15 Oct, 2018 11:58 34.32 Kb 145
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