Obese responded to weekly vitamin D better than non-obese – RCT March 2018

The effects of three regimens of cholecalciferol (vitamin D3) supplementation on vitamin D deficiency in non-obese and obese females.

Arch Med Sci Atheroscler Dis. 2018 Mar 27;3:e60-e67. doi: 10.5114/amsad.2018.74784
Imga NN1, Berker D1, Can B1, Guler S1.

VitaminDWiki

This study: Daily vs. Weekly 50,000 IU oral Vitamin D for 8 weeks


Obese lost more weight on diet if added 50,000 IU of vitamin D weekly – many RCTs

A sampling of the many RCT which found weekly to work well (often 50,000 IU was used)

Weekly may be BETTER than daily


Non weekly

1 or 2 per month may be BETTER than daily

Take vitamin D3 daily, weekly, or bi-weekly has the following

  • Notional chart for Vitamin D supplementation for levels < 30 nanograms

see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=2475

  • Notional chart of Vitamin D benefit vs dosing frequency for > 50 nanograms

see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=2475
Notional chart for Vitamin D supplementation for levels < 30 nanograms
see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=2475

 Download the PDF from VitaminDWiki
Image
Note: vitamin D levels dropped by the 6th month asthere was no dosing after the 8th week

Vitamin D deficiency is a common health problem worldwide and tends to be a risk factor for all-cause mortality. We evaluated the effect of continuous low-dose oral daily and loading dose of oral weekly and loading monthly intramuscular (IM) vitamin D3 regimens on circulating levels of total 25(OH)D and in vitamin D deficient females, and between non-obese and obese subgroups.

MATERIAL AND METHODS:
A total of 231 vitamin D deficient females were included to the study. According to treatment regimen, patients were divided into three groups:

  • daily continuous oral,
  • loading dose of weekly oral
  • and monthly intramuscular.

All patients in treatment groups were divided into non-obese (105) and obese (126) groups. Serum 25(OH)D and parathormone (PTH) levels were evaluated at baseline and at the third and sixth month.

RESULTS:
In obese patients oral weekly loading regimen and in non-obese patients oral daily continuous regimens were found to be more potent. Baseline PTH levels decreased when compared with the third and sixth months (p < 0.001), but between the third and sixth months it was not changed (p = 0.783).

CONCLUSIONS:

  • Oral daily regimen in non-obese patients and
  • loading weekly oral regimen in obese patients

were more effective in achieving the target levels of 25(OH)D concentration above 30 ng/ml and provided a stable plasma vitamin D concentration over a long period of time.

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