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Fewer white spots in MRI brain scans if had more vitamin D – Jan 2014

Association of White Matter Hyperintensities with Low Serum 25-Hydroxyvitamin D Levels

American Journal of Neuroradiology
J.M. Prager, jprager at northshore.org, C. Thomas, W.J. Ankenbrandt, J.R. Meyer, Y. Gao, A. Ragin, S. Sidharthan, R. Hutten and Y.G. Wu
From the Department of Radiology (J.M.P., W.J.A., J.R.M., R.H., Y.G.W.), NorthShore University Health System, Evanston, Illinois; Department of Endocrinology (C.T.), University of Chicago, Chicago, Illinois; Departments of Statistics (Y.G.) and Radiology (A.R.), Northwestern University, Evanston, Illinois; and Department of Radiology (S.S.), Monmouth Medical Center, Long Branch, New Jersey.

BACKGROUND AND PURPOSE: Vitamin D deficiency is associated with cognitive impairment in the elderly and with increased white matter T2 hyperintensities in elderly debilitated patients. We investigated the relationship between serum vitamin D and brain MR findings in adult outpatients.

MATERIALS AND METHODS: Brain MR studies of 56 patients ages 30–69 years were selected when vitamin D level had been obtained within 90 days of the MRI. White matter T2 hyperintensities were characterized by size and location by two neuroradiologists. Manual volumetric analysis was assessed in patients more than 50 years of age.

RESULTS: The entire cohort showed a significant negative relationship between serum 25-hydroxyvitamin D and the number of confluent juxtacortical white matter T2 hyperintensities (P = .047). The cohort ages 50 years and older showed stronger correlation between confluent white matter T2 hyperintensities and serum 25-hydroxyvitamin D in the juxtacortical region; number (P = .015) and size of white matter T2 hyperintensities (P = .048). Atrophy was not significantly related to serum 25-hydroxyvitamin D by radiologist visual analysis or by the bicaudate ratio.

CONCLUSIONS: We found a significant relationship between vitamin D and white matter T2 hyperintensities in independent adult outpatients, especially over the age of 50 years.
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VitaminDWiki observation and hypothesis

- Fact: Hyperintensities (low blood flow) are fewer in those with lots of vitamin D (see above)
- Fact: Multiple Sclerosis Hyperintensities go into remission with lots of vitamin D (see below)
- Fact: Hypertensities predict Dimentia, Mortality, and Stroke (BMJ 2010, below)
- Fact: Vitamin D prevents dimentia, mortality, and stroke
Hypothesis: Will be able look at brain scans, and not wait for dimentia, mortality, or stoke to determin how much vitamin D is needed.

See also VitaminDWiki

Before = 2008

Starting daily dose 25,000 IU; increased in stages to 80,000 IU on October 28, 2010. Asymptomatic since 2010.

After = 2013

See also web

Hyperintensity = 1.9X increased chance of getting Dimentia


Hyperintensity = 2.0X increase chance of Death


Hyperintensity = 3.5X increased chance of getting a Stroke


Fewer white spots in MRI brain scans if had more vitamin D – Jan 2014        
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Attached files

ID Name Comment Uploaded Size Downloads
15354 .Association of white matter hyperintensities.pdf admin 31 Mar, 2021 422.25 Kb 322
3549 Hyperintensity BMJ.pdf admin 17 Jan, 2014 202.52 Kb 1692
3548 BMJ Risk of stroke.jpg admin 17 Jan, 2014 38.27 Kb 3966
3547 BMJ Mortality.jpg admin 17 Jan, 2014 39.23 Kb 3985
3546 BMJ Dimentia.jpg admin 17 Jan, 2014 40.99 Kb 3962