The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study
Nutrients 2020,12, 2742; doi:10.3390/nu12092742
Sarah Hakeem 1,2,3, Nuno Mendonca 1,2,4,5, Terry Aspray 6, , Andrew Kingston , CarmenRuiz-Martin CarolJagger John C.Mathers O/Rachel Duncan7 and Tom R.Hill 1,2' tom.hill at ncl.ac.uk
- Fraility and Vitamin D - many studies
- 80 percent of the characteristics of frailty associated with low vitamin D – May 2013
- Frailty 9X more likely if low vitamin D – Nov 2015
- Frailty risk increases 12 percent for every 10 ng less vitamin D – meta-analysis Sept 2018
- Majority of frail hospital patients had low vitamin D, which did not change with season – 2018
Seniors category starts with
see also
Overview Seniors and Vitamin D
Muscle in VitaminDWiki title,
Overview Fractures and Falls and Vitamin D
Overview Alzheimer's-Cognition and Vitamin D
Overview Cancer and vitamin D
Overview Influenza and vitamin D
Overview Diabetes and vitamin D
Hearing Loss appears to be prevented and treated with vitamin D
Overview Osteoporosis and vitamin D
Restless Legs Syndrome dramatically reduced by vitamin D, etc
Overview Rheumatoid Arthritis and vitamin D
Fraility and Vitamin D - many studies many studies
Search VitaminDWIKI for "GAIT SPEED" 173 items as of Aug 2020
10 reasons why seniors need more vitamin D has the following
- Senior skin produces 3X less Vitamin D for the same sun intensity
- Seniors have fewer vitamin D receptors as they age
- Seniors are indoors more than than when they were younger
- not as agile, weaker muscles; frail, no longer enjoy hot temperatures
- (if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc.
- Seniors wear more clothing outdoors than when younger
- Seniors also are told to fear skin cancer/wrinkles
- Seniors often take various drugs which reduce vitamin D
- Some reductions would not show up on vitamin D test
- statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
- Seniors often have one or more diseases which consume vitamin D
- osteoporosis, diabetes, MS, ...
- Seniors generally put on weight at they age - and a heavier body requires more vitamin D
- Seniors often (40%) have fatty livers – which do not process vitamin D as well
- Reduced stomach acid ==>less Magnesium needed to utilize vitamin D
(would not show up on vitamin D test) - Seniors with poorly functioning kidneys do not process vitamin D as well
(would not show up on vitamin D test) 2009 full text online Also PDF 2009 - Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)
- Category Seniors and Vitamin D
390 items Download the PDF from VitaminDWiki
Model 4Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate' 25(OH)D concentration which might protect against a faster disability trajectory.
Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25-50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18,36 and 60 months.
Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.
85 year olds who were not Vitamin D deficient had and continued to have few disabilities – Sept 2020(Cached) Printer Friendly Follow this page for updates2162 visitors, last modified 29 Nov, 2020, This page is in the following categories (# of items in each category)Attached files
ID Name Comment Uploaded Size Downloads 14635 disability 3 curves.jpg admin 29 Nov, 2020 18:05 47.65 Kb 245 14634 Trajectory model 4.jpg admin 29 Nov, 2020 18:01 44.17 Kb 218 14633 Disability Trajectories.pdf PDF 2020 admin 29 Nov, 2020 18:01 747.84 Kb 245